The role of NO-cGMP pathway inhibition in vascular endothelial-dependent smooth muscle relaxation disorder of AT1-AA positive rats: protective effects of adiponectin

Nitric Oxide ◽  
2019 ◽  
Vol 87 ◽  
pp. 10-22 ◽  
Author(s):  
Zhiyuan Wang ◽  
Ye Wu ◽  
Suli Zhang ◽  
Yuhui Zhao ◽  
Xiaochen Yin ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Vascular Endothelial ◽  
Protective Effects ◽  
Cgmp Pathway ◽  
Pathway Inhibition

Role of cGMP in relaxation of vascular and other smooth muscle

1989 ◽  
Vol 67 (4) ◽  
pp. 251-262 ◽  
Author(s):  
Kanji Nakatsu ◽  
Jack Diamond
Keyword(s):  
Smooth Muscle ◽  
Muscle Relaxation ◽  
Smooth Muscles ◽  
Phosphodiesterase Inhibitors ◽  
Current Evidence ◽  
Smooth Muscle Relaxation ◽  
Drug Induced ◽  
Intracellular Cgmp ◽  
Tissue Content

The hypothesis that the relaxant action of many drugs on vascular and other smooth muscle is mediated by increases in intracellular cGMP, the "cGMP hypothesis," is gaining wide acceptance. While much information supporting this idea can be found in the literature, there is also a significant amount of information indicating that an elevation in the tissue content of cGMP is by itself insufficient to cause smooth muscle relaxation. The literature is reviewed with reference to the criteria that need to be fulfilled to consider cGMP as the second messenger mediating relaxation of smooth muscle by a drug; i.e., activation of guanylate cyclase, elevation of tissue content of cGMP, potentiation by phosphodiesterase inhibitors, antagonism by inhibitors of cGMP synthesis, and production of relaxation by cGMP analogues. For each criterion, key observations supporting the hypothesis are considered, followed by examples of important observations not consistent with the hypothesis. It is concluded that in some smooth muscles, for example, rat myometrium and vas deferens, cGMP is not a mediator of drug-induced relaxation. In other smooth muscles, including vascular smooth muscle, cGMP appears to play an important role in the relaxation process; but current evidence suggests that other factors are also important and that the cGMP hypothesis may need to be modified.Key words: cGMP, vascular relaxation, smooth muscle relaxation, vasodilators.

Interactions between nitroglycerin and endothelium in vascular smooth muscle relaxation

1991 ◽  
Vol 260 (3) ◽  
pp. H698-H701 ◽  
Author(s):  
J. L. Dinerman ◽  
D. L. Lawson ◽  
J. L. Mehta
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
No Production ◽  
Cyclic Monophosphate ◽  
The Mean ◽  
Smooth Muscle Relaxant ◽  
Vascular Smooth Muscle Relaxation

To evaluate the role of endothelium in nitroglycerin (NTG)-mediated vascular relaxation, epinephrine-contracted rat thoracic aortic segments with and without intact endothelium were exposed to NTG (10(-10) to 10(-5) M). Aortic segments with intact (endo+, n = 15) and denuded endothelium (endo-, n = 9) exhibited typical NTG-induced relaxation. However, the mean effective concentration of NTG was lower for endo- than for endo+ segments (P less than 0.001). To determine if this phenomenon related to nitric oxide (NO) generation by endothelium, six endo+ segments were treated with NG-monomethyl-L-arginine (L-NMMA), an inhibitor of NO production. These endo+ segments exhibited greater (P less than 0.001) relaxation in response to NTG than the untreated endo+ segments. Oxyhemoglobin, an inhibitor of guanylate cyclase activation, greatly diminished NTG-mediated relaxation of all aortic segments. To determine if the enhanced NTG-mediated relaxation of endo- segments was unique to the guanosine 3',5'-cyclic monophosphate-dependent vasodilator NTG, other endo+ and endo- segments were exposed to adenosine 3',5'-cyclic monophosphate-dependent vasodilator papaverine (10(-8) to 10(-4) M), and no difference in EC50 was noted between endo+ and endo- segments. Thus endothelium attenuates NTG-mediated vasorelaxation, and this attenuation is abolished by inhibition of endothelial NO production with L-NMMA. These observations indicate that endothelium is a dynamic modulator of vascular smooth muscle relaxant effects of NTG. This modulation appears to result from a competitive interaction between endothelial NO and NTG.

Cellular mechanism underlying hydrogen sulfide induced mouse tracheal smooth muscle relaxation: Role of BKCa

2014 ◽  
Vol 741 ◽  
pp. 55-63 ◽  
Author(s):  
Jiehong Huang ◽  
Yu-li Luo ◽  
Yuan Hao ◽  
Yi-lin Zhang ◽  
Peng-xiao Chen ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Hydrogen Sulfide ◽  
Muscle Relaxation ◽  
Cellular Mechanism ◽  
Tracheal Smooth Muscle ◽  
Smooth Muscle Relaxation

scholarly journals The role of cytoskeleton in the regulation of contractile activity in smooth muscle cells from aorta of rats

2007 ◽  
Vol 6 (1) ◽  
pp. 78-82
Author(s):  
S. V. Gousakova
Keyword(s):  
Smooth Muscle ◽  
Contractile Activity ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Aortic Smooth Muscle ◽  
Physiologically Active Substances ◽  
Cytochalasine B ◽  
Smooth Muscle Contractions ◽  
System Operating

Influence of cytoskeleton modulation by Colchicine and Cytochalasine B on contractile reactions of smooth muscle segments of rat's aorta caused by physiologically active substances, the membrane's depolarization and cells' striction was investigated by mechanographical method. Microtubules and actinic elements of the cytoskeleton were established to participate in the development of hyper-potassic and phenylephrine -induced contractions as well as in the smooth muscle relaxation induced by cAMP. Cytochalasine B suppresses both kinds of aortic smooth muscle contractions more effectively than Colchicine. Contractile reactions at isoosmotic striction are suppressed only by Cytochalasine. Efficacy of cAMP signal system operating depends on actinic cyto-skeleton integrity.

ROLE OF CYCLIC GMP IN CORONARY SMOOTH MUSCLE RELAXATION

Abstracts ◽  
1978 ◽  
pp. 793 ◽  
Author(s):  
S. Holzmann ◽  
A. Wurm ◽  
G. Pöch ◽  
W.R. Kukovetz
Keyword(s):  
Smooth Muscle ◽  
Cyclic Gmp ◽  
Muscle Relaxation ◽  
Smooth Muscle Relaxation ◽  
Coronary Smooth Muscle
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