scholarly journals A high fat diet induces sex-specific differences in hepatic lipid metabolism and nitrite/nitrate in rats

Nitric Oxide ◽  
2016 ◽  
Vol 54 ◽  
pp. 51-59 ◽  
Author(s):  
Julijana Stanimirovic ◽  
Milan Obradovic ◽  
Aleksandra Jovanovic ◽  
Emina Sudar-Milovanovic ◽  
Sonja Zafirovic ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
High Fat ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Nitrite Nitrate

Perinatal maternal high-fat diet promotes alterations in hepatic lipid metabolism and resistance to the hypolipidemic effect of fish oil in adolescent rat offspring

2016 ◽  
Vol 60 (11) ◽  
pp. 2493-2504 ◽  
Author(s):  
Lorraine S. Oliveira ◽  
Luana L. Souza ◽  
Aline F. P. Souza ◽  
Aline Cordeiro ◽  
George E. G. Kluck ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Fish Oil ◽  
High Fat Diet ◽  
Hypolipidemic Effect ◽  
High Fat ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Rat Offspring

scholarly journals Maternal high-fat diet consumption modulates hepatic lipid metabolism and microRNA-122 (miR-122) and microRNA-370 (miR-370) expression in offspring

2014 ◽  
Vol 111 (12) ◽  
pp. 2112-2122 ◽  
Author(s):  
R. O. Benatti ◽  
A. M. Melo ◽  
F. O. Borges ◽  
L. M. Ignacio-Souza ◽  
L. A. P. Simino ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Lipid Metabolism ◽  
High Fat Diet ◽  
Fatty Acid Synthase ◽  
High Fat ◽  
Hepatic Lipid Metabolism ◽  
Expression Levels ◽  
Hepatic Lipid ◽  
Pregnancy And Lactation ◽  
Maternal Consumption

Maternal consumption of a high-fat diet (HFD) during pregnancy and lactation is closely related to hepatic lipid accumulation, insulin resistance and increased serum cytokine levels in offspring and into their adulthood. MicroRNA (miRNA) have been implicated in cholesterol biosynthesis and fatty acid metabolism. We evaluated the modulation of hepatic fatty acid synthesis (de novo), β-oxidation pathways, and miRNA-122 (miR-122) and miRNA-370 (miR-370) expression in recently weaned offspring (day 28) of mouse dams fed a HFD (HFD-O) or a standard chow (SC-O) during pregnancy and lactation. Compared with SC-O mice, HFD-O mice weighed more, had a larger adipose tissue mass and were more intolerant to glucose and insulin (P< 0·05). HFD-O mice also presented more levels of serum cholesterol, TAG, NEFA and hepatic IκB kinase and c-Jun N-terminal kinase phosphorylation compared with SC-O mice (P< 0·05). Protein levels of fatty acid synthase, acetyl-CoA carboxylase and 3-hydroxy-3-methylglutaryl-CoA reductase were similar in HFD-O and SC-O mice, whereas expression levels of SCD1 mRNA and protein were more abundant in HFD-O mice than in SC-O mice (P< 0·05). Interestingly, mRNA expression levels of the β-oxidation-related genes ACADVL and CPT1 were decreased in HFD-O mice (P< 0·05). Furthermore, the expression of miR-122 was reduced but that of miR-370 was increased in HFD-O mice compared with that in SC-O mice (P< 0·05). Changes in hepatic lipid metabolism were accompanied by increased mRNA content of AGPAT1 and TAG deposition in HFD-O mice (P< 0·05). Taken together, the present results strongly suggest that maternal consumption of a HFD affects the early lipid metabolism of offspring by modulating the expression of hepatic β-oxidation-related genes and miRNA that can contribute to metabolic disturbances in adult life.

Aging exacerbates high‐fat diet‐induced steatohepatitis through alteration in hepatic lipid metabolism in mice

2020 ◽  
Vol 35 (8) ◽  
pp. 1437-1448 ◽  
Author(s):  
Kei Ishizuka ◽  
Kazuyoshi Kon ◽  
Hyeon‐Cheol Lee‐Okada ◽  
Kumiko Arai ◽  
Akira Uchiyama ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
High Fat ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid

Effect of lignin-derived lignophenols on hepatic lipid metabolism in rats fed a high-fat diet

2012 ◽  
Vol 34 (2) ◽  
pp. 228-234 ◽  
Author(s):  
Shin Sato ◽  
Yuuka Mukai ◽  
Yukari Tokuoka ◽  
Keigo Mikame ◽  
Masamitsu Funaoka ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
High Fat ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid

Disturbance of di-(2-ethylhexyl) phthalate in hepatic lipid metabolism in rats fed with high fat diet

2020 ◽  
Vol 146 ◽  
pp. 111848
Author(s):  
Yuexia Zhang ◽  
Shanshan Ge ◽  
Zhenhua Yang ◽  
Zhongping Li ◽  
Xiaojuan Gong ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
High Fat ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Ethylhexyl Phthalate

Short- and long-term effects of high-fat diet feeding and voluntary exercise on hepatic lipid metabolism in mice

2018 ◽  
Vol 507 (1-4) ◽  
pp. 291-296 ◽  
Author(s):  
Saki Yoshimura ◽  
Shihoko Nakashima ◽  
Yuki Tomiga ◽  
Shotaro Kawakami ◽  
Yoshinari Uehara ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Fat Diet ◽  
Voluntary Exercise ◽  
Long Term Effects ◽  
High Fat ◽  
Hepatic Lipid Metabolism ◽  
Hepatic Lipid ◽  
Short And Long Term
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