Nitric oxide signaling in human ovarian cancer: A potential therapeutic target

Nitric Oxide ◽  
2016 ◽  
Vol 54 ◽  
pp. 30-37 ◽  
Author(s):  
Ahmed El-Sehemy ◽  
Lynne-Marie Postovit ◽  
YangXin Fu
Keyword(s):  
Nitric Oxide ◽  
Ovarian Cancer ◽  
Therapeutic Target ◽  
Human Ovarian Cancer ◽  
Potential Therapeutic Target ◽  
Nitric Oxide Signaling

T-LAK Cell-Originated Protein Kinase (TOPK) as a Prognostic Factor and a Potential Therapeutic Target in Ovarian Cancer

2016 ◽  
Vol 22 (24) ◽  
pp. 6110-6117 ◽  
Author(s):  
Yuji Ikeda ◽  
Jae-Hyun Park ◽  
Takashi Miyamoto ◽  
Naofumi Takamatsu ◽  
Taigo Kato ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Protein Kinase ◽  
Prognostic Factor ◽  
Therapeutic Target ◽  
Potential Therapeutic Target ◽  
Lak Cell

scholarly journals Interleukin-6 as a Therapeutic Target in Human Ovarian Cancer

2011 ◽  
Vol 17 (18) ◽  
pp. 6083-6096 ◽  
Author(s):  
Jermaine Coward ◽  
Hagen Kulbe ◽  
Probir Chakravarty ◽  
David Leader ◽  
Vessela Vassileva ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Interleukin 6 ◽  
Therapeutic Target ◽  
Human Ovarian Cancer

Cyclin E as a potential therapeutic target in high grade serous ovarian cancer

2016 ◽  
Vol 143 (1) ◽  
pp. 152-158 ◽  
Author(s):  
J. Kanska ◽  
M. Zakhour ◽  
B. Taylor-Harding ◽  
B.Y. Karlan ◽  
W.R. Wiedemeyer
Keyword(s):  
Ovarian Cancer ◽  
Therapeutic Target ◽  
Cyclin E ◽  
High Grade ◽  
Serous Ovarian Cancer ◽  
Potential Therapeutic Target

scholarly journals Genetic Association of Interleukin-31 Gene Polymorphisms with Epithelial Ovarian Cancer in Chinese Population

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Chenlu Liu ◽  
Yanyun Wang ◽  
Huizi Song ◽  
Qin Li ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Epithelial Ovarian Cancer ◽  
Therapeutic Target ◽  
Gene Polymorphisms ◽  
Chinese Population ◽  
Clinical Characteristics ◽  
Chinese Women ◽  
Healthy Individuals ◽  
Potential Therapeutic Target ◽  
Kaplan Meier

Roles of interleukin-31 (IL-31) in the development and progression of human epithelial ovarian cancer are largely unknown. Studies report that the polymorphisms, rs7977932 C>G and rs4758680 C>A in IL-31, affect the expression level of IL-31. In the present study, we examined 412 patients with epithelial ovarian cancer and 428 healthy individuals to explore whether these polymorphisms are associated with the epithelial ovarian cancer in Chinese women. The genotype of the polymorphisms in each individual was identified. The associations of the polymorphisms with patients’ clinical characteristics and outcomes were evaluated. For rs7977932, the frequency of the CG/GG was significantly decreased in patients with epithelial ovarian cancer. However, the frequency of the rs4758680 CA/AA was significantly increased in those patients. Moreover, the frequency of rs7977932 CG/GG genotype was significantly higher in patients with less advanced FIGO stages. Kaplan-Meier curve showed that patients with CG/GG genotypes of rs7977932 had a decreased risk for recurrence compared to those with CC genotype. Our findings suggested that rs7977932 and rs4758680 of IL-31 may be associated with the development and progression of the epithelial ovarian cancer in the Chinese population. IL-31, therefore, may be a potential therapeutic target for the development of drugs to treat the disease.

scholarly journals Identification of FGFR4 as a Potential Therapeutic Target for Advanced-Stage, High-Grade Serous Ovarian Cancer

2013 ◽  
Vol 19 (4) ◽  
pp. 809-820 ◽  
Author(s):  
Tarrik M. Zaid ◽  
Tsz-Lun Yeung ◽  
Melissa S. Thompson ◽  
Cecilia S. Leung ◽  
Tom Harding ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Therapeutic Target ◽  
High Grade ◽  
Advanced Stage ◽  
Serous Ovarian Cancer ◽  
Potential Therapeutic Target

Rho-kinase as a therapeutic target in vascular diseases: Striking nitric oxide signaling

Nitric Oxide ◽  
2014 ◽  
Vol 43 ◽  
pp. 45-54 ◽  
Author(s):  
Gopi Krishna Kolluru ◽  
Syamantak Majumder ◽  
Suvro Chatterjee
Keyword(s):  
Nitric Oxide ◽  
Therapeutic Target ◽  
Rho Kinase ◽  
Vascular Diseases ◽  
Nitric Oxide Signaling

scholarly journals Notch3 Overexpression as Potential Therapeutic Target in Advanced Stage Chemoresistant Ovarian Cancer

2012 ◽  
Vol 138 (4) ◽  
pp. 535-544 ◽  
Author(s):  
Mohammed Tanjimur Rahman ◽  
Kentaro Nakayama ◽  
Munmun Rahman ◽  
Hiroshi Katagiri ◽  
Atsuko Katagiri ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Therapeutic Target ◽  
Advanced Stage ◽  
Potential Therapeutic Target ◽  
Chemoresistant Ovarian Cancer
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