scholarly journals Acute dietary nitrate supplementation improves arterial endothelial function at high altitude: A double-blinded randomized controlled cross over study

Nitric Oxide ◽  
2015 ◽  
Vol 50 ◽  
pp. 58-64 ◽  
Author(s):  
Emily Bakker ◽  
Harald Engan ◽  
Alexander Patrician ◽  
Erika Schagatay ◽  
Trine Karlsen ◽  
...  
Keyword(s):  
Endothelial Function ◽  
High Altitude ◽  
Dietary Nitrate ◽  
Randomized Controlled ◽  
Nitrate Supplementation ◽  
Double Blinded

Effects Of Dietary Nitrate Supplementation On Endothelial Function At High Altitude

2014 ◽  
Vol 46 ◽  
pp. 424
Author(s):  
Emily Bakker ◽  
Harald Engan ◽  
Alexander Patrician ◽  
Erika Schagatay ◽  
Trine Karlsen ◽  
...  
Keyword(s):  
Endothelial Function ◽  
High Altitude ◽  
Dietary Nitrate ◽  
Nitrate Supplementation

Short-term tibolone does not interfere with endothelial function: a double-blinded, randomized, controlled trial

Climacteric ◽  
2016 ◽  
Vol 19 (3) ◽  
pp. 299-302 ◽  
Author(s):  
M. F. S. Celani ◽  
R. Hurtado ◽  
A. H. F. Brandão ◽  
A. M. R. Maciel da Fonseca ◽  
S. Geber
Keyword(s):  
Randomized Controlled Trial ◽  
Endothelial Function ◽  
Controlled Trial ◽  
Short Term ◽  
Randomized Controlled ◽  
Double Blinded

Abstract P243: Endothelial Function, Arterial Stiffness and Central Blood Pressure are Not Affected by a Single Dose of Dietary Nitrate in Healthy Normotensive Females

Circulation ◽  
2018 ◽  
Vol 137 (suppl_1) ◽  
Author(s):  
Katharine E Storo ◽  
Caleb D Harrison ◽  
Evan J Bockover ◽  
Brycen J Ratcliffe ◽  
Sierra Crowe ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Single Dose ◽  
Arterial Stiffness ◽  
Endothelial Function ◽  
Pulse Wave ◽  
Central Blood Pressure ◽  
Future Research ◽  
Dietary Nitrate ◽  
Nitrate Supplementation ◽  
Plasma Nitrite

Intro: Hypertension is a prominent risk factor for cardiovascular disease and arterial stiffness is a related predictor of both mortality and longitudinal onset of hypertension in normotensive individuals. Both vascular compliance and blood pressure have been shown to improve following dietary nitrate supplementation in some healthy and diseased individuals. Dietary nitrate supplementation increases plasma nitrite and may, therefore, enhance bioavailability of endothelium derived nitric oxide. Chronic increased flow mediated dilation (FMD) and reduction of pulse wave velocity (PWV) reduce a person’s long-term risk for developing endothelial dysfunction, atherosclerosis and hypertension. Hypothesis: We hypothesized that an acute dose of dietary nitrate would improve FMD, decrease PWV and reduce central blood pressure (cBP) in healthy, young females. Methods: Seven healthy, young (21 ± 2 years) females participated in a randomized, double blind, placebo controlled, crossover protocol. Participants had endothelial function measured via FMD, arterial stiffness via PWV and applanation tonometry, and cBP was determined non-invasively using pulse wave analysis following a 12-hour fasting period and 48-hour NIH approved low nitrate diet. Baseline values were measured the day before each treatment visit (placebo or nitrate-rich, separated by a 1-week washout period). Participants consumed either a placebo or nitrate-rich supplement (negligible and 6.2 mmol nitrate, respectively) 2 hours prior to their laboratory visit. Upon arrival, blood was drawn and participants assumed a supine position for 15 minutes. Then brachial artery FMD was assessed via high definition ultrasound imaging following 5 minutes of proximal forearm occlusion, followed by PWV and central blood pressure measurements. Results: Plasma nitrite was elevated following consumption of the nitrate rich supplement compared to placebo (26.33 ± 15.76 and 1.18 ± 0.96 arbitrary units, respectively; p<0.05). However, there was no difference between nitrate rich and placebo treatments for endothelial function as measured by FMD (10.33 ± 1.82 and 9.11 ± 5.43%, respectively; p=0.70). No difference was present between nitrate and placebo groups for PWV (5.99 ± 0.85 and 6.16 ± 0.80 m/s, respectively; p=0.90), systolic cBP (101.57 ± 9.29 and 96.90 ± 20.95 mmHg, respectively; p=0.40) and diastolic cBP (72.57 ± 7.67 and 73.20 ± 5.01 mmHg, respectively; p=0.97). Conclusion: While a single dose of dietary nitrate does increase plasma nitrite, supplementation has minimal effects on FMD, PWV and cBP in young healthy females. Future research should examine longer duration supplementation protocols as well as the changes in vascular health of patients with known disease such as hypertension or peripheral artery disease.

scholarly journals Dietary nitrate supplementation to enhance exercise capacity in hypoxic COPD: EDEN-OX, a double-blind, placebo-controlled, randomised cross-over study

Thorax ◽  
2021 ◽  
pp. thoraxjnl-2021-217147
Author(s):  
Matthew J Pavitt ◽  
Adam Lewis ◽  
Sara C Buttery ◽  
Bernadette O Fernandez ◽  
Monika Mikus-Lelinska ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Area Under The Curve ◽  
Supplemental Oxygen ◽  
Test Time ◽  
Walk Test ◽  
Double Blind ◽  
Dietary Nitrate ◽  
Double Blind Placebo ◽  
Nitrate Supplementation ◽  
Exercise Endurance

RationaleDietary nitrate supplementation improves skeletal muscle oxygen utilisation and vascular endothelial function. We hypothesised that these effects might be sufficient to improve exercise performance in patients with COPD and hypoxia severe enough to require supplemental oxygen.MethodsWe conducted a single-centre, double-blind, placebo-controlled, cross-over study, enrolling adults with COPD who were established users of long-term oxygen therapy. Participants performed an endurance shuttle walk test, using their prescribed oxygen, 3 hours after consuming either 140 mL of nitrate-rich beetroot juice (BRJ) (12.9 mmol nitrate) or placebo (nitrate-depleted BRJ). Treatment order was allocated (1:1) by computer-generated block randomisation.MeasurementsThe primary outcome was endurance shuttle walk test time. The secondary outcomes included area under the curve to isotime for fingertip oxygen saturation and heart rate parameters during the test, blood pressure, and endothelial function assessed using flow-mediated dilatation. Plasma nitrate and nitrite levels as well as FENO were also measured.Main results20 participants were recruited and all completed the study. Nitrate-rich BRJ supplementation prolonged exercise endurance time in all participants as compared with placebo: median (IQR) 194.6 (147.5–411.7) s vs 159.1 (121.9–298.5) s, estimated treatment effect 62 (33–106) s (p<0.0001). Supplementation also improved endothelial function: NR-BRJ group +4.1% (−1.1% to 14.8%) vs placebo BRJ group −5.0% (−10.6% to –0.6%) (p=0.0003).ConclusionAcute dietary nitrate supplementation increases exercise endurance in patients with COPD who require supplemental oxygen.Trial registration numberISRCTN14888729.

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