P11 Determination pharmacokinetic properties and cardioprotective effects of a novel hydrogen sulfide agent – Controlled release formulation of S-propargyl-cysteine on acute myocardial infarction rats

Nitric Oxide ◽  
2014 ◽  
Vol 39 ◽  
pp. S19
Author(s):  
BaHieu Tran ◽  
Shujun Wang ◽  
Yi-Zhun Zhu
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Hydrogen Sulfide ◽  
Controlled Release ◽  
Release Formulation ◽  
Controlled Release Formulation ◽  
Pharmacokinetic Properties ◽  
Cardioprotective Effects

scholarly journals Cardioprotective effects and pharmacokinetic properties of a controlled release formulation of a novel hydrogen sulfide donor in rats with acute myocardial infarction

2015 ◽  
Vol 35 (3) ◽  
Author(s):  
Ba Hieu Tran ◽  
Chengrong Huang ◽  
Qiuyan Zhang ◽  
Xu Liu ◽  
Shizhou Lin ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Hydrogen Sulfide ◽  
Controlled Release ◽  
Cardiovascular Diseases ◽  
Release Formulation ◽  
Controlled Release Formulation ◽  
Pharmacokinetic Properties ◽  
Cardioprotective Effects

The present study confirms that CR-SPRC is stable, effective and is thus an alternative candidate for hydrogen sulfide-mediated long-term prevention of cardiovascular diseases.

Pharmacokinetic Properties of a New Controlled-Release Formulation of Carvedilol

2006 ◽  
Vol 98 (7) ◽  
pp. 5-16 ◽  
Author(s):  
David M. Tenero ◽  
Linda S. Henderson ◽  
Charlotte A. Baidoo ◽  
Angela H. Harter ◽  
Andrea M. Campanile ◽  
...  
Keyword(s):  
Controlled Release ◽  
Release Formulation ◽  
Controlled Release Formulation ◽  
Pharmacokinetic Properties

Preinfarction Angina and Improved Reperfusion of the Infarct-related Artery

1999 ◽  
Vol 82 (S 01) ◽  
pp. 68-72 ◽  
Author(s):  
Alessandro Sciahbasi ◽  
Eugenia De Marco ◽  
Attilio Maseri ◽  
Felicita Andreotti
Keyword(s):  
Myocardial Infarction ◽  
Acute Myocardial Infarction ◽  
Infarct Size ◽  
Ischemic Preconditioning ◽  
Early Reperfusion ◽  
Vast Number ◽  
Beneficial Effects ◽  
Infarct Related Artery ◽  
Cardioprotective Effects ◽  
Collateral Vessels

SummaryPreinfarction angina and early reperfusion of the infarct-related artery are major determinants of reduced infarct-size in patients with acute myocardial infarction. The beneficial effects of preinfarction angina on infarct size have been attributed to the development of collateral vessels and/or to post-ischemic myocardial protection. However, recently, a relation has been found between prodromal angina, faster coronary recanalization, and smaller infarcts in patients treated with rt-PA: those with preinfarction angina showed earlier reperfusion (p = 0.006) and a 50% reduction of CKMB-estimated infarct-size (p = 0.009) compared to patients without preinfarction angina. This intriguing observation is consistent with a subsequent observation of higher coronary recanalization rates following thrombolysis in patients with prodromal preinfarction angina compared to patients without antecedent angina. Recent findings in dogs show an enhanced spontaneous lysis of plateletrich coronary thrombi with ischemic preconditioning, which is prevented by adenosine blockade, suggesting an antithrom-botic effect of ischemic metabolites. Understanding the mechanisms responsible for earlier and enhanced coronary recanalization in patients with preinfarction angina may open the way to new reperfusion strategies.A vast number of studies, globally involving ≈17,000 patients with acute myocardial infarction, have unequivocally shown that an infarction preceded by angina evolves into a smaller area of necrosis compared to an infarct not preceded by angina (Table 1) (1). So far, preinfarction angina has been thought to have cardioprotective effects mainly through two mechanisms: collateral perfusion of the infarctzone (2-4), and ischemic preconditioning of the myocardium (5-7). Here we discuss a further mechanism of protection represented by improved reperfusion of the infarct-related artery.

Optimization Study to Develop Once-a-day Controlled Release Formulation of Metoclopramide with Predictable Design Space

1970 ◽  
Vol 1 (1) ◽  
pp. 71-76
Author(s):  
Rajesh Dubey ◽  
Udaya K. Chowdary ◽  
Venkateswarlu V.
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Design Space ◽  
Release Kinetics ◽  
Release Profile ◽  
Release Formulation ◽  
Linear Effect ◽  
Controlled Release Formulation ◽  
The Difference ◽  
Face Centered

A controlled release formulation of metoclopramide was developed using a combination of hypromellose (HPMC) and hydrogenated castor oil (HCO). Developed formulations released the drug over 20 hr with release kinetics following Higuchi model. Compared to HCO, HPMC showed significantly higher influence in controlling the drug release at initial as well as later phase. The difference in the influence can be explained by the different swelling and erosion behaviour of the polymers. Effect of the polymers on release was optimized using a face-centered central composite design to generate a predictable design space. Statistical analysis of the drug release at various levels indicated a linear effect of the polymers’ levels on the drug release. The release profile of formulations containing the polymer levels at extremes of their ranges in design space was found to be similar to the predicted release profile

scholarly journals Controlled release formulation of an anti-depression drug based on a L-phenylalanate-zinc layered hydroxide intercalation compound

2017 ◽  
Vol 105 ◽  
pp. 35-44 ◽  
Author(s):  
Norhayati Hashim ◽  
Sharifah Norain Mohd Sharif ◽  
Illyas Md Isa ◽  
Shahidah Abdul Hamid ◽  
Mohd Zobir Hussein ◽  
...  
Keyword(s):  
Controlled Release ◽  
Intercalation Compound ◽  
Release Formulation ◽  
Controlled Release Formulation ◽  
Zinc Layered Hydroxide
Sign in / Sign up

Export Citation Format

Share Document