Nitric oxide-mediated activity in anti-cancer photodynamic therapy

Nitric Oxide ◽  
2013 ◽  
Vol 30 ◽  
pp. 26-35 ◽  
Author(s):  
Valentina Rapozzi ◽  
Emilia Della Pietra ◽  
Sonia Zorzet ◽  
Marina Zacchigna ◽  
Benjamin Bonavida ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Photodynamic Therapy ◽  
Anti Cancer

Multiple Means by Which Nitric Oxide can Antagonize Photodynamic Therapy

2016 ◽  
Vol 23 (24) ◽  
pp. 2754-2769 ◽  
Author(s):  
Albert W. Girotti ◽  
Jonathan M. Fahey ◽  
Witold Korytowski
Keyword(s):  
Nitric Oxide ◽  
Photodynamic Therapy

scholarly journals Cold Atmospheric Pressure Plasma-Activated Medium Induces Selective Cell Death in Human Hepatocellular Carcinoma Cells Independently of Singlet Oxygen, Hydrogen Peroxide, Nitric Oxide and Nitrite/Nitrate

2021 ◽  
Vol 22 (11) ◽  
pp. 5548
Author(s):  
Yan Li ◽  
Tianyu Tang ◽  
Haejune Lee ◽  
Kiwon Song
Keyword(s):  
Nitric Oxide ◽  
Cell Death ◽  
Singlet Oxygen ◽  
Atmospheric Pressure ◽  
Atmospheric Pressure Plasma ◽  
Proliferative Effect ◽  
Huh7 Cells ◽  
Anti Cancer ◽  
Cold Atmospheric Pressure Plasma ◽  
Nitrite Nitrate

Cold atmospheric pressure plasma (CAP) and plasma-activated medium (PAM) induce cell death in diverse cancer cells and may function as powerful anti-cancer agents. The main components responsible for the selective anti-cancer effects of CAP and PAM remain elusive. CAP or PAM induces selective cell death in hepatocellular carcinoma cell lines Hep3B and Huh7 containing populations with cancer stem cell markers. Here, we investigated the major component(s) of CAP and PAM for mediating the selective anti-proliferative effect on Hep3B and Huh7 cells. The anti-proliferative effect of CAP was mediated through the medium; however, the reactive oxygen species scavenger N-acetyl cysteine did not suppress PAM-induced cell death. Neither high concentrations of nitrite or nitrite/nitrate nor a low concentration of H2O2 present in the PAM containing sodium pyruvate affected the viability of Hep3B and Huh7 cells. Inhibitors of singlet oxygen, superoxide anions, and nitric oxide retained the capacity of PAM to induce anti-cancer effects. The anti-cancer effect was largely blocked in the PAM prepared by placing an aluminum metal mesh, but not a dielectric PVC mesh, between the plasma source and the medium. Hence, singlet oxygen, hydrogen peroxide, nitric oxide, and nitrite/nitrate are not the main factors responsible for PAM-mediated selective death in Hep3B and Huh7 cells. Other factors, such as charged particles including various ions in CAP and PAM, may induce selective anti-cancer effects in certain cancer cells.

Microneedles Loaded with Glutathione-Scavenging Complex for Nitric Oxide Enhanced Photodynamic Therapy of Melanoma

2021 ◽  
Author(s):  
Fan Jia ◽  
Weijiang Yu ◽  
Xinfang Li ◽  
Yonghang Chen ◽  
Youxiang Wang ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Photodynamic Therapy

scholarly journals Synthesis and anti-cancer potential of the positional isomers of NOSH-aspirin (NBS-1120) a dual nitric oxide and hydrogen sulfide releasing hybrid

2015 ◽  
Vol 25 (20) ◽  
pp. 4677-4682 ◽  
Author(s):  
Federica Vannini ◽  
Andrew C. MacKessack-Leitch ◽  
Erin K. Eschbach ◽  
Mitali Chattopadhyay ◽  
Ravinder Kodela ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Hydrogen Sulfide ◽  
Positional Isomers ◽  
Anti Cancer

scholarly journals Antagonistic Effects of Endogenous Nitric Oxide in a Glioblastoma Photodynamic Therapy Model

2016 ◽  
Vol 92 (6) ◽  
pp. 842-853 ◽  
Author(s):  
Jonathan M. Fahey ◽  
Joseph V. Emmer ◽  
Witold Korytowski ◽  
Neil Hogg ◽  
Albert W. Girotti
Keyword(s):  
Nitric Oxide ◽  
Photodynamic Therapy ◽  
Antagonistic Effects ◽  
Endogenous Nitric Oxide ◽  
Therapy Model
Sign in / Sign up

Export Citation Format

Share Document