P62 The H2S-donor sodium hydrogen sulphide effectively attenuates TNF-α and IL-6 expression in the human monocyte cell line U937

Nitric Oxide ◽  
2012 ◽  
Vol 27 ◽  
pp. S39 ◽  
Author(s):  
Burkhard Kloesch ◽  
Silvia Loebsch ◽  
Guenter Steiner
Keyword(s):  
Cell Line ◽  
Hydrogen Sulphide ◽  
Human Monocyte ◽  
Sodium Hydrogen ◽  
Tnf Α ◽  
Human Monocyte Cell Line ◽  
Monocyte Cell

Human monocyte cell line (U937) releases suppressive IgG-binding factor(s)

1986 ◽  
Vol 16 (1) ◽  
pp. 25-30 ◽  
Author(s):  
Charles Félix Calvo ◽  
Shinichiro Watanabe ◽  
Didier Mètivier ◽  
Anna Senik
Keyword(s):  
Cell Line ◽  
Human Monocyte ◽  
Igg Binding ◽  
Binding Factor ◽  
Human Monocyte Cell Line ◽  
Monocyte Cell

Reovirus Strain-Dependent Inflammatory Cytokine Responses and Replication Patterns in a Human Monocyte Cell Line

2006 ◽  
Vol 19 (3) ◽  
pp. 546-557 ◽  
Author(s):  
Anthony L. Farone ◽  
Sean M. O'donnell ◽  
Chad S. Brooks ◽  
Kristel M. Young ◽  
Janene M. Pierce ◽  
...  
Keyword(s):  
Cell Line ◽  
Inflammatory Cytokine ◽  
Human Monocyte ◽  
Cytokine Responses ◽  
Human Monocyte Cell Line ◽  
Monocyte Cell ◽  
Strain Dependent

Effect of 1α,25-dihydroxyvitamin D3 on polyamine metabolism in human monocyte cell line-U937

1989 ◽  
Vol 21 (11) ◽  
pp. 1287-1294 ◽  
Author(s):  
Yukioka Kazuhiko ◽  
Otani Shuzo ◽  
Matsui-Yuasa Isao ◽  
Goto Hitoshi ◽  
Tahara Hideki ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Monocyte ◽  
Polyamine Metabolism ◽  
Dihydroxyvitamin D3 ◽  
Human Monocyte Cell Line ◽  
Monocyte Cell

Space flight affects motility and cytoskeletal structures in human monocyte cell line J-111

Cytoskeleton ◽  
2011 ◽  
Vol 68 (2) ◽  
pp. 125-137 ◽  
Author(s):  
Maria Antonia Meloni ◽  
Grazia Galleri ◽  
Giuseppe Pani ◽  
Angela Saba ◽  
Proto Pippia ◽  
...  
Keyword(s):  
Cell Line ◽  
Space Flight ◽  
Human Monocyte ◽  
Human Monocyte Cell Line ◽  
Monocyte Cell

Serum of Bipolar Patients Induces Pro-inflammatory Activation of Macrophages

2017 ◽  
Vol 41 (S1) ◽  
pp. S114-S114
Author(s):  
S. Dubou Serafim ◽  
P. Ferrari ◽  
R. Colombo ◽  
L. Paul Géa ◽  
M. Migliorini Parisi ◽  
...  
Keyword(s):  
Human Monocyte ◽  
Mononuclear Phagocyte ◽  
M2 Polarization ◽  
Tnf Α ◽  
Inflammatory Activation ◽  
Human Monocyte Cell Line ◽  
Monocyte Cell ◽  
Competing Interest ◽  
Immune Imbalance ◽  
Bipolar Patients

IntroductionEvidence has suggested that immune imbalance is involved with bipolar disorder (BD); however, its precise mechanism is poorly understood.ObjectiveThis study investigated whether biochemical changes in the serum from BD patients could modulate the phenotype of macrophages.MethodsEighteen subjects with BD and healthy individuals (n = 5) were included in this study. The human monocyte cell line U-937 was activated with PMA (phorbol 12-myristate 13-acetate) and polarization was induced with RPMI-1640 media supplemented with 10% serum from each patient for 24 h. Gene expression of selected M1 and M2 markers was assessed by qPCR.ResultsMacrophages exposed to serum of manic and depressive BD patients displayed an increase of IL-1β (6.40 ± 3.47 and 9.04 ± 5.84 versus 0.23 ± 0.11; P < 0.05) and TNF-α (2.23 ± 0.91 and 2.03 ± 0.45 versus 0.62 ± 0.24; P = 0.002 and P = 0.004, respectively) compared to remitted group. In parallel, U-937 macrophages treated with serum of patients in acute episode displayed a down-regulation of CXCL9 (0.29 ± 0.20 versus 1.86 ± 1.61; P = 0.006) and CXCL10 expression (0.36 ± 0.15 and 0.86 ± 0.24 versus 1.83 ± 0.88; P < 0.000 and P = 0.04) compared to remitters.ConclusionsOur results are consistent with previous studies showing that changes in peripheral blood markers could modulate M1/M2 polarization in BD. The evidence of macrophages as source of inflammatory cytokines might be helpful to unravel how the mononuclear phagocyte system can be involved in the etiology of BD.Disclosure of interestThe authors have not supplied their declaration of competing interest.

Identification of neurotensin receptors on a human monocyte cell line THP1

Neuropeptides ◽  
1993 ◽  
Vol 24 (4) ◽  
pp. 242
Author(s):  
M.-C. Burgevin ◽  
D. Quarteronet ◽  
N. Munoz ◽  
H.M. Soria ◽  
A. Crespo ◽  
...  
Keyword(s):  
Cell Line ◽  
Human Monocyte ◽  
Neurotensin Receptors ◽  
Human Monocyte Cell Line ◽  
Monocyte Cell
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