P4 Antiinflammatory and antinociceptive effects of ATB-346, a gastric sparing hydrogen sulfide-releasing naproxen, in rats with carrageenan-induced knee joint synovitis

Nitric Oxide ◽  
2012 ◽  
Vol 27 ◽  
pp. S13 ◽  
Author(s):  
Eduardo Ekundi-Valentim ◽  
Leandro Rodrigues ◽  
Karen Santos ◽  
Simone Teixeira ◽  
John Wallace ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Knee Joint ◽  
Antinociceptive Effects ◽  
Knee Joint Synovitis

P34 Mechanisms underlying the protective effect of H2S donors against carrageenan-induced knee joint synovitis and nociception

Nitric Oxide ◽  
2013 ◽  
Vol 31 ◽  
pp. S49-S50
Author(s):  
Filiphe P.N. Mesquita ◽  
Leandro Rodrigues ◽  
Bruna C. Santos ◽  
Cristiane I. Zanoni ◽  
Juliana Florenzano ◽  
...  
Keyword(s):  
Knee Joint ◽  
Protective Effect ◽  
Knee Joint Synovitis

scholarly journals Comprehensive assessment of knee joint synovitis at 7 T MRI using contrast-enhanced and non-enhanced sequences

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Christoph Treutlein ◽  
Tobias Bäuerle ◽  
Armin M. Nagel ◽  
Ali Guermazi ◽  
Arnd Kleyer ◽  
...  
Keyword(s):  
Knee Joint ◽  
Comprehensive Assessment ◽  
Contrast Enhanced ◽  
Knee Joint Synovitis

Prospective sonographic and arthroscopic evaluation of proliferative knee joint synovitis.

1994 ◽  
Vol 13 (11) ◽  
pp. 855-862 ◽  
Author(s):  
L Rubaltelli ◽  
U Fiocco ◽  
L Cozzi ◽  
M Baldovin ◽  
C Rigon ◽  
...  
Keyword(s):  
Knee Joint ◽  
Arthroscopic Evaluation ◽  
Knee Joint Synovitis

Doppler ultrasound measurements of knee joint synovitis in rheumatoid arthritis patients treated with infliximab

2007 ◽  
Vol 17 (5) ◽  
pp. 376-379 ◽  
Author(s):  
Reiji Kasukawa ◽  
Kiori Shio ◽  
Yukiko Kanno ◽  
Ai Sato ◽  
Atsushi Takahashi ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Knee Joint ◽  
Doppler Ultrasound ◽  
Ultrasound Measurements ◽  
Knee Joint Synovitis

Knee joint synovitis in Sjo¨gren's syndrome. Sonographic study

2002 ◽  
Vol 31 (5) ◽  
pp. 291-295 ◽  
Author(s):  
A. Iagnocco ◽  
G. Coari ◽  
G. Palombi ◽  
G. Valesini
Keyword(s):  
Knee Joint ◽  
Knee Joint Synovitis

scholarly journals Knee joint synovitis: study of correlations and diagnostic performances of ultrasonography compared with histopathology

RMD Open ◽  
2018 ◽  
Vol 4 (1) ◽  
pp. e000616 ◽  
Author(s):  
Aurélie Najm ◽  
Carl Orr ◽  
Lorna Gallagher ◽  
Monika Biniecka ◽  
Emeline Gaigneux ◽  
...  
Keyword(s):  
Knee Joint ◽  
Knee Joint Synovitis

The Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Mice

2020 ◽  
pp. 1-7
Author(s):  
Zeynep Cetin ◽  
Ozgur Gunduz ◽  
Ruhan D. Topuz ◽  
Dikmen Dokmeci ◽  
Hakan C. Karadag ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Physical Dependence ◽  
Morphine Tolerance ◽  
Morphine Dependence ◽  
Tail Flick ◽  
Pain Mechanisms ◽  
Antinociceptive Effects ◽  
Synthase Inhibitor ◽  
Development Of Tolerance

<b><i>Objective:</i></b> Hydrogen sulfide is an endogenous gaseous mediator that has been indicated to have a role in pain mechanisms. In this study, we aimed to detect brain and spinal cord hydrogen sulfide levels during different phases of tolerance and dependence to morphine and to determine the effects of inhibition of endogenous hydrogen sulfide production on the development of tolerance and dependence. <b><i>Methods:</i></b> Morphine tolerance and dependence was developed by subcutaneous injection of morphine (10 mg/kg) twice daily for 12 days. Physical dependence was determined by counting the jumps for 20 min, which is a withdrawal symptom occurring after a single dose of naloxone (5 mg/kg) administered intraperitoneally (i.p.). Propargylglycine (30 mg/kg, i.p.), a cystathionine-γ-lyase inhibitor, and hydroxylamine (12.5 mg/kg, i.p.), a cystathionine-β-synthase inhibitor, were used as hydrogen sulfide synthase inhibitors. The tail-flick and hot-plate tests were used to determine the loss of antinociceptive effects of morphine and development of tolerance. <b><i>Results:</i></b> It was found that chronic and acute uses of both propargylglycine and hydroxylamine prevented the development of tolerance to morphine, whereas they had no effect on morphine dependence. Chronic and acute administrations of hydrogen sulfide synthase inhibitors did not exert any difference in hydrogen sulfide levels in brain and spinal cords of both morphine-tolerant and -dependent animals. <b><i>Conclusion:</i></b> It has been concluded that hydrogen sulfide synthase inhibitors may have utility in preventing morphine tolerance.

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