scholarly journals Nitrite and nitric oxide metabolism in peripheral artery disease

Nitric Oxide ◽  
2012 ◽  
Vol 26 (4) ◽  
pp. 217-222 ◽  
Author(s):  
Jason D. Allen ◽  
Tony Giordano ◽  
Christopher G. Kevil
Keyword(s):  
Nitric Oxide ◽  
Peripheral Artery Disease ◽  
Peripheral Artery ◽  
Nitric Oxide Metabolism ◽  
Artery Disease

Nitric oxide donors for peripheral artery disease

2018 ◽  
Vol 39 ◽  
pp. 77-85 ◽  
Author(s):  
Debbie Falconer ◽  
Nikolaos Papageorgiou ◽  
Karim Salem ◽  
Wei Yao Lim ◽  
Athanasios Katsargyris ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Peripheral Artery Disease ◽  
Nitric Oxide Donors ◽  
Peripheral Artery ◽  
Artery Disease

scholarly journals The Nitric Oxide System in Peripheral Artery Disease: Connection with Oxidative Stress and Biopterins

Antioxidants ◽  
2020 ◽  
Vol 9 (7) ◽  
pp. 590
Author(s):  
Ahmed Ismaeel ◽  
Evlampia Papoutsi ◽  
Dimitrios Miserlis ◽  
Ramon Lavado ◽  
Gleb Haynatzki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Nitric Oxide ◽  
Endothelial Dysfunction ◽  
Peripheral Artery Disease ◽  
Oxide System ◽  
Protein Carbonyls ◽  
Nitric Oxides ◽  
Peripheral Artery ◽  
No Bioavailability ◽  
Artery Disease

Peripheral artery disease (PAD) pathophysiology extends beyond hemodynamics to include other operating mechanisms, including endothelial dysfunction. Oxidative stress may be linked to endothelial dysfunction by reducing nitric oxide (NO) bioavailability. We aimed to investigate whether the NO system and its regulators are altered in the setting of PAD and to assess the relationship between NO bioavailability and oxidative stress. Sera from 35 patients with intermittent claudication (IC), 26 patients with critical limb ischemia (CLI), and 35 non-PAD controls were analyzed to determine levels of tetrahydrobiopterin (BH4), dihydrobiopterin (BH2), nitrate/nitrite (nitric oxides, or NOx), arginine, citrulline, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), and the oxidative stress markers 8-Oxo-2′-deoxyguanosine (8-OHdG), 4-hydroxynonenal (4-HNE), advanced glycation end products (AGEs), and protein carbonyls. NOx was significantly lower in IC and CLI patients compared to controls in association with elevated oxidative stress, with the greatest NOx reductions observed in CLI. Compared with controls, IC and CLI patients had reduced BH4, elevated BH2, and a reduced BH4/BH2 ratio. SDMA, the arginine/SDMA ratio, and the arginine/ADMA ratio were significantly higher in CLI patients. The NO system and its regulators are significantly compromised in PAD. This dysregulation appears to be driven by increased oxidative stress and worsens as the disease progresses from claudication to CLI.

Associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm – a grin without a cat!

VASA ◽  
2017 ◽  
Vol 46 (3) ◽  
pp. 151-158 ◽  
Author(s):  
Hisato Takagi ◽  
Takuya Umemoto
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Peripheral Artery Disease ◽  
Literature Search ◽  
Systematic Literature Search ◽  
Peripheral Artery ◽  
Epidemiological Evidence ◽  
Abdominal Aortic ◽  
Artery Disease ◽  
Meta Analyses

Abstract. Both coronary and peripheral artery disease are representative atherosclerotic diseases, which are also known to be positively associated with presence of abdominal aortic aneurysm. It is still controversial, however, whether coronary and peripheral artery disease are positively associated with expansion and rupture as well as presence of abdominal aortic aneurysm. In the present article, we overviewed epidemiological evidence, i. e. meta-analyses, regarding the associations of coronary and peripheral artery disease with presence, expansion, and rupture of abdominal aortic aneurysm through a systematic literature search. Our exhaustive search identified seven meta-analyses, which suggest that both coronary and peripheral artery disease are positively associated with presence of abdominal aortic aneurysm, may be negatively associated with expansion of abdominal aortic aneurysm, and might be unassociated with rupture of abdominal aortic aneurysm.

Concordance of Glucose-Based and of HbA1c-Based Diagnoses of Diabetes in Patients with Peripheral Artery Disease—A Comparison between Two Age Groups

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1522-P
Author(s):  
CHRISTOPH H. SAELY ◽  
ALEXANDER VONBANK ◽  
CHRISTINE HEINZLE ◽  
DANIELA ZANOLIN ◽  
BARBARA LARCHER ◽  
...  
Keyword(s):  
Peripheral Artery Disease ◽  
Age Groups ◽  
Peripheral Artery ◽  
Artery Disease ◽  
Two Age Groups

2217-PUB: Type 2 Diabetes Is a Strong Predictor for LDL Cholesterol Target Achievement in Patients with Peripheral Artery Disease

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2217-PUB
Author(s):  
SIMON STERNBAUER ◽  
ALEXANDER VONBANK ◽  
CHRISTINE HEINZLE ◽  
DANIELA ZANOLIN-PURIN ◽  
JÖRN F. DOPHEIDE ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Artery Disease ◽  
Ldl Cholesterol ◽  
Strong Predictor ◽  
Peripheral Artery ◽  
Artery Disease
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