Involvement of nitric oxide in acute lung inflammation induced by cigarette smoke in the mouse

Nitric Oxide ◽  
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pp. 175-181 ◽  
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Samuel Santos Valença ◽  
Wagner Alves Pimenta ◽  
Carlos Romualdo Rueff-Barroso ◽  
Thiago Santos Ferreira ◽  
Ângela Castro Resende ◽  
...  
2011 ◽  
Vol 10 (5) ◽  
pp. 7290.2011.00010 ◽  
Author(s):  
Sandra Pérez-Rial ◽  
Laura del Puerto-Nevado ◽  
Nicolás González-Mangado ◽  
Germán Peces-Barba

2014 ◽  
Vol 18 (2) ◽  
pp. 358-364 ◽  
Author(s):  
Liang-liang Shen ◽  
Ya-nan Liu ◽  
Hui-juan Shen ◽  
Chong Wen ◽  
Yong-liang Jia ◽  
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2016 ◽  
Vol 41 ◽  
pp. 11-18 ◽  
Author(s):  
Emanuel Kennedy-Feitosa ◽  
Renata Tiemi Okuro ◽  
Vanessa Pinho Ribeiro ◽  
Manuella Lanzetti ◽  
Marina Valente Barroso ◽  
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2011 ◽  
Vol 37 (10) ◽  
pp. 627-632 ◽  
Author(s):  
Xueting Bai ◽  
Yicun Chen ◽  
Weizhou Chen ◽  
Huaping Lei ◽  
Fenfei Gao ◽  
...  

2015 ◽  
Vol 87 ◽  
pp. S136
Author(s):  
Manuella Lanzetti ◽  
Emanuel Kennedy-Feitosa ◽  
Renata Tiemi Okuto ◽  
Vanessa Pinho Ribeiro ◽  
Walter Araujo Zin ◽  
...  

2010 ◽  
Vol 29 (4) ◽  
pp. 329-337 ◽  
Author(s):  
Shi Cheng ◽  
Wen-Mao Yan ◽  
Bin Yang ◽  
Jing-dong Shi ◽  
Mao-min Song ◽  
...  

To investigate the role of nitric oxide (NO) in acute lung inflammation and injury secondary to acute necrotizing pancreatitis (ANP), 5% sodium taurocholate was retrogradely injected into the biliopancreatic duct of rats to ANP model. These ANP rats were given L-Arginine (L-Arg, 100 mg/kg), L-NAME (10 mg/kg), or their combination by intraperitoneal injection 30 min prior to ANP induction. At 1, 3, 6, and 12 hours after ANP induction, lung NO production, and inducible NO synthase (iNOS) expression were measured. Lung histopathological changes, bronchoalveolar lavage (BAL) protein concentration, proinflammatory mediators tumor necrotic factor alpha (TNF-α), and lung tissue myeloperoxidase (MPO) activity were examined. Results showed that NO production and iNOS mRNA expression in alveolar macrophages (AMs) were significantly increased along with significant increases in lung histological abnormalities and BAL proteins in the ANP group, all of which were further enhanced by pretreatment with L-Arg and attenuated by pretreatment with L-NAME, respectively. These markers were slightly attenuated by pretreatment with combination of L-Arg + L-NAME, suggesting that NO is required for initiating the acute lung damage in ANP rats, and also that L-Arg-enhanced lung injury is mediated by its NO generation rather than its direct effect. MPO activity and TNF-α expression in lung were upregulated in the ANP rats and further enhanced by pretreatment with L-Arg and attenuated by pretreatment with L-NAME, respectively. These results suggest that overproduction of NO mediated by iNOS in the lung is required for the acute lung inflammation and damage secondary to ANP.


Phytomedicine ◽  
2012 ◽  
Vol 19 (3-4) ◽  
pp. 262-269 ◽  
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Roberto Soares de Moura ◽  
Thiago Santos Ferreira ◽  
Alan Aguiar Lopes ◽  
Karla Maria Pereira Pires ◽  
Renata Tiscoski Nesi ◽  
...  

2008 ◽  
Vol 9 (1) ◽  
Author(s):  
Li Nie ◽  
Ruolan Xiang ◽  
Weixun Zhou ◽  
Bao Lu ◽  
Deyun Cheng ◽  
...  

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