Sustained release nitric oxide releasing nanoparticles: Characterization of a novel delivery platform based on nitrite containing hydrogel/glass composites

Nitric Oxide ◽  
2008 ◽  
Vol 19 (1) ◽  
pp. 12-20 ◽  
Author(s):  
Adam J. Friedman ◽  
George Han ◽  
Mahantesh S. Navati ◽  
Manju Chacko ◽  
Leslie Gunther ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Sustained Release ◽  
Glass Composites ◽  
Delivery Platform ◽  
Nanoparticles Characterization ◽  
Nitric Oxide Releasing

scholarly journals Design, synthesis, and biological characterization of potential antiatherogenic nitric oxide releasing tocopherol analogs

2005 ◽  
Vol 13 (20) ◽  
pp. 5787-5796 ◽  
Author(s):  
Gloria V. López ◽  
Carlos Batthyány ◽  
Fabiana Blanco ◽  
Horacio Botti ◽  
Andrés Trostchansky ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Biological Characterization ◽  
Design Synthesis ◽  
Nitric Oxide Releasing

scholarly journals Development of Antimicrobial Nitric Oxide-Releasing Fibers

Pharmaceutics ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1445
Author(s):  
Daniel C. Wang ◽  
Justin R. Clark ◽  
Richard Lee ◽  
Adam H. Nelson ◽  
Anthony W. Maresso ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Release Kinetics ◽  
Antimicrobial Properties ◽  
No Donor ◽  
Long Term Stability ◽  
Effective Delivery ◽  
Culture Models ◽  
Delivery Platform ◽  
Nitric Oxide Releasing

Nitric oxide (NO) is a highly reactive gas molecule, exhibiting antimicrobial properties. Because of its reactive nature, it is challenging to store and deliver NO efficiently as a therapeutic agent. The objective of this study was to develop NO-releasing polymeric fibers (NO-fibers), as an effective delivery platform for NO. NO-fibers were fabricated with biopolymer solutions of polyvinyl pyrrolidone (PVP) and ethylcellulose (EC), and derivatives of N-diazeniumdiolate (NONOate) as NO donor molecules, using an electrospinning system. We evaluated in vitro NO release kinetics, along with antimicrobial effects and cytotoxicity in microorganisms and human cell culture models. We also studied the long-term stability of NONOates in NO-fibers over 12 months. We demonstrated that the NO-fibers could release NO over 24 h, and showed inhibition of the growth of Pseudomonas aeruginosa (P. aeruginosa) and methicillin-resistant Staphylococcus aureus (MRSA), without causing cytotoxicity in human cells. NO-fibers were able to store NONOates for over 12 months at room temperature. This study presents the development of NO-fibers, and the feasibility of NO-fibers to efficiently store and deliver NO, which can be further developed as a bandage.

scholarly journals Characterization of a novel antibiofilm effect of nitric oxide-releasing aspirin (NCX-4040) on Candida albicans isolates from denture stomatitis patients

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0176755 ◽  
Author(s):  
Francisco Madariaga-Venegas ◽  
Roberto Fernández-Soto ◽  
Luisa Fernanda Duarte ◽  
Nicole Suarez ◽  
Daniela Delgadillo ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Candida Albicans ◽  
Denture Stomatitis ◽  
Nitric Oxide Releasing

scholarly journals The preparation and characterization of nitric oxide releasing silicone rubber materials impregnated with S-nitroso-tert-dodecyl mercaptan

2016 ◽  
Vol 4 (3) ◽  
pp. 422-430 ◽  
Author(s):  
Alex R. Ketchum ◽  
Michael P. Kappler ◽  
Jianfeng Wu ◽  
Chuanwu Xi ◽  
Mark E. Meyerhoff
Keyword(s):  
Nitric Oxide ◽  
Antimicrobial Activity ◽  
Silicone Rubber ◽  
Storage Stability ◽  
No Release ◽  
Nitric Oxide Releasing ◽  
Dodecyl Mercaptan

Silicone rubber catheters impregnated with S-nitroso-tert-dodecylmercaptan demonstrate long term NO release, minimal leaching, considerable antimicrobial activity, and reasonable storage stability.

Fabrication and Characterization of a Nitric Oxide-Releasing Nanofibrous Gelatin Matrix

2013 ◽  
Vol 14 (8) ◽  
pp. 2521-2530 ◽  
Author(s):  
Caleb Vogt ◽  
Qi Xing ◽  
Weilue He ◽  
Bowen Li ◽  
Megan C. Frost ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gelatin Matrix ◽  
Fabrication And Characterization ◽  
Nitric Oxide Releasing

Novel β-galactosidase-specific O2-glycosylated diazeniumdiolate probes

2010 ◽  
Vol 88 (9) ◽  
pp. 969-980 ◽  
Author(s):  
Barry J. Bedell ◽  
D. Scott Bohle ◽  
Zhijie Chua ◽  
Alexander Czerniewski ◽  
Alan C. Evans ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Cell Membranes ◽  
Synthesis And Characterization ◽  
Imaging Agents ◽  
Mri Imaging ◽  
No Donors ◽  
Molecular Mri ◽  
Nitric Oxide Releasing

Three β-galactosidase-specific nitric-oxide-releasing diazeniumdiolate conjugated probes were prepared as a prelude to studies of new potential molecular MRI imaging agents. A glycosylated derivative, 2e, designed to be trafficked across cell membranes, was also prepared. We report, in detail, the synthesis and characterization of these probes. In addition, the release of diazeniumdiolate from the probes by β-galactosidase-catalyzed hydrolysis was used to estimate their efficacy as serum-stable, specific NO donors.

scholarly journals Characterization of an S-nitroso-N-acetylpenicillamine–based nitric oxide releasing polymer from a translational perspective

2016 ◽  
Vol 65 (15) ◽  
pp. 769-778 ◽  
Author(s):  
Marcus J. Goudie ◽  
Elizabeth J. Brisbois ◽  
Jitendra Pant ◽  
Alex Thompson ◽  
Joseph A. Potkay ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Releasing
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