Nitric oxide involvement in the effect of acute lithium administration on the nonadrenergic noncholinergic-mediated relaxation of rat gastric fundus

Nitric Oxide ◽  
2007 ◽  
Vol 17 (3-4) ◽  
pp. 152-159 ◽  
Author(s):  
Mehdi Ghasemi ◽  
Ali Reza Karimollah ◽  
Ahmad Reza Dehpour
Keyword(s):  
Nitric Oxide ◽  
Gastric Fundus ◽  
Rat Gastric Fundus ◽  
Acute Lithium

Relaxant effect of atorvastatin on isolated rat gastric fundus strips: implications for Ca2+-signalling mechanisms

2019 ◽  
Vol 97 (5) ◽  
pp. 413-421 ◽  
Author(s):  
Deniz Kaleli-Durman ◽  
F. İlkay Alp-Yıldırım ◽  
Osman Özdemir ◽  
B. Sönmez Uydeş-Doğan
Keyword(s):  
Nitric Oxide ◽  
Smooth Muscle ◽  
Mevalonate Pathway ◽  
Muscle Tone ◽  
Gastric Fundus ◽  
Lipid Lowering ◽  
Nitric Oxide Synthase Inhibitor ◽  
Relaxant Effect ◽  
Rat Gastric Fundus ◽  
Isolated Rat

Statins are determined to have various pleiotropic effects apart from their lipid-lowering properties. Herein, we investigated the direct effects of atorvastatin on gastric smooth muscle tone. Atorvastatin effectively relaxed isolated rat gastric fundus strips precontracted with acetylcholine, potassium chloride, and serotonin. Incubation of the strips with nitric oxide synthase inhibitor, l-NOARG (10−4 M, 20 min), l-type voltage-operated Ca2+ channel (VOCC) blocker, nifedipine (10−6 M, 30 min), KATP channel blocker, glibenclamide (10−5 M, 30 min), or precursor of cholesterol, mevalonate (10−2 M, 45 min) did not change the relaxations to atorvastatin. However, pretreatment of fundus strips with atorvastatin (3×10−5–3×10−4 M, 30 min) inhibited the contractions to calcium chloride (10−4–10−1 M), acetylcholine (10–4 M), and caffeine (20 mM) in the calcium-free medium. Moreover, atorvastatin reduced the contractions induced by sarco-endoplasmic reticulum Ca2+-ATPase (SERCA) inhibitor, cyclopiazonic acid (10−7–3×10−5 M). The current study demonstrated that atorvastatin produces an acute relaxant effect on gastric fundus strips, which appears to be mediated by several Ca2+-signalling mechanisms such as the blockade of l-type VOCC-independent Ca2+ entry, decrease in smooth muscle Ca2+ sensitivity, inhibition of IP3- and ryanodine-sensitive intracellular stores to mediate Ca2+ release, as well as the activation of SERCA. This acute relaxing effect seems unlikely to be related with nitric oxide, KATP channels, and the mevalonate pathway.

Effect of Biliary Cirrhosis on Neurogenic Relaxation of Rat Gastric Fundus and Anococcygeus Muscle: Role of Nitric Oxide Pathway

2014 ◽  
Vol 59 (11) ◽  
pp. 2675-2681 ◽  
Author(s):  
Mehdi Ghasemi ◽  
Ali Reza Karimollah ◽  
Bardia Bakhtiari ◽  
Abbas Ghasemi ◽  
Leila Moezi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Gastric Fundus ◽  
Biliary Cirrhosis ◽  
Anococcygeus Muscle ◽  
Rat Gastric Fundus ◽  
Nitric Oxide Pathway
Sign in / Sign up

Export Citation Format

Share Document