Down-regulation of matrix metalloproteinase-9 expression by nitric oxide in lipopolysaccharide-stimulated rat primary astrocytes

Nitric Oxide ◽  
2007 ◽  
Vol 16 (4) ◽  
pp. 425-432 ◽  
Author(s):  
Chan Young Shin ◽  
Woo Jong Lee ◽  
Ji Woong Choi ◽  
Min Sik Choi ◽  
Jae Ryun Ryu ◽  
...  
2002 ◽  
Vol 104 (1) ◽  
pp. 15-21 ◽  
Author(s):  
Matthew J. Eagleton ◽  
David A. Peterson ◽  
Vita V. Sullivan ◽  
Karen J. Roelofs ◽  
John A. Ford ◽  
...  

2008 ◽  
Vol 376 (4) ◽  
pp. 743-747 ◽  
Author(s):  
Jun-Seok Ahn ◽  
Min-kyung Kim ◽  
Jang-hee Hahn ◽  
Jung-Hyeun Park ◽  
Kyeong-Han Park ◽  
...  

2008 ◽  
Vol 76 (4) ◽  
pp. 368-375 ◽  
Author(s):  
Min Sik Choi ◽  
Young Eun Kim ◽  
Woo Jong Lee ◽  
Ji Woong Choi ◽  
Gyu Hwan Park ◽  
...  

Author(s):  
Angel Mercy Sylus ◽  
Hanumanthappa Nandeesha ◽  
Thiagaraju Chitra

Background: Obesity, inflammation and alterations in matrix metalloproteinase-9 (MMP-9) and nitric oxide (NO) levels are involved in the development of polycystic ovary syndrome (PCOS). Objective: To investigate the relationship of MMP-9, NO and interleukin-10 (IL-10) with the increase in body mass index (BMI) in women with PCOS. Materials and Methods: Sixty two infertile PCOS women were included in the study. Serum levels of NO, IL-10 and MMP-9 were assessed in the women with increase in BMI. Results: MMP-9 was significantly increased (p = 0.029) and IL-10 (p = 0.015) was significantly reduced in obese PCOS subjects compared to those with lesser BMI. MMP- 9 levels positively correlated with the duration of infertility (r = 0.253, p = 0.047) and negatively correlated with NO levels (r = - 0.259, p = 0.042). A significant negative correlation between the interleukin-10 levels and the BMI (r = - 0.272, p = 0.033) was also found in the PCOS subjects. Conclusion: MMP-9 levels are increased in obese PCOS women and it is associated with NO levels and the duration of infertility. Key words: Body mass index, Interleukin-10, Nitric oxide, Matrix metalloproteinase-9.


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