P128. Congenital nitric oxide synthase 3 (NOS3) deficiency prevents the systemic hypertensive reaction to tetrameric hemoglobin infusion

Nitric Oxide ◽  
2006 ◽  
Vol 14 (4) ◽  
pp. 59-60
Author(s):  
Binglan Yu ◽  
Fumito Ichinose ◽  
Kenneth D. Bloch ◽  
Warren M. Zapol
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Nitric Oxide Synthase 3 ◽  
Hypertensive Reaction ◽  
Oxide Synthase

scholarly journals Nitric Oxide Synthase 3-Mediated Neurodegeneration After Intracerebral Gene Delivery

2007 ◽  
Vol 66 (4) ◽  
pp. 272-283 ◽  
Author(s):  
Suzanne M. de la Monte ◽  
Ami Jhaveri ◽  
Bradley A. Maron ◽  
Jack R. Wands
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Gene Delivery ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

scholarly journals Stimulatory Roles of Nitric-oxide Synthase 3 and Guanylyl Cyclase in Platelet Activation

2005 ◽  
Vol 280 (45) ◽  
pp. 37430-37438 ◽  
Author(s):  
Jasna A. Marjanovic ◽  
Zhenyu Li ◽  
Aleksandra Stojanovic ◽  
Xiaoping Du
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Platelet Activation ◽  
Guanylyl Cyclase ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

Effects of lipoproteins from pre-eclamptic women on umbilical endothelial cell 6-oxo-prostaglandin F1α and endothelin 1 synthesis, and nitric oxide synthase 3 mRNA expression

1999 ◽  
Vol 97 (6) ◽  
pp. 697-706 ◽  
Author(s):  
A. BARDEN ◽  
L. J. BEILIN ◽  
K. BOTH ◽  
J. RITCHIE ◽  
P. LEEDMAN ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Endothelial Cell ◽  
Nitric Oxide Synthase ◽  
Pregnant Women ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Endothelin 1 ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

In order to evaluate whether lipid abnormalities may contribute to endothelial dysfunction in pre-eclampsia, the present study examined the in vitro effects of very-low-density lipoprotein (VLDL), low-density lipoprotein (LDL) and high-density lipoprotein (HDL), isolated from women with pre-eclampsia and matched controls, on the endothelial synthesis of 6-oxo-prostaglandin F1α (6-oxo-PGF1α; a metabolite of prostacyclin) and endothelin 1, and on the expression of nitric oxide synthase 3 (NOS3) mRNA. VLDL, LDL and HDL cholesterol were isolated from 20 pre-eclamptic and 20 age- and gestation-matched normal pregnant women. The lipoproteins (50 μg/ml) and lipoprotein-free control plasma were incubated for 1, 3 and 6 h at 37 °C with a human umbilical endothelial cell line. The synthesis of 6-oxo-PGF1α and endothelin 1, and NOS3 mRNA expression, were measured at each time point. VLDL from pre-eclamptic women stimulated endothelial cell 6-oxo-PGF1α synthesis to a lesser extent than that from normal pregnant women (P< 0.05). LDL from women with pre-eclampsia also stimulated 6-oxo-PGF1α synthesis to a lesser extent than LDL from normal pregnant women, but the effect was less sustained. The effect of HDL from women with pre-eclampsia on 6-oxo-PGF1α synthesis was similar to that of HDL from normal pregnant women. The pre-incubation levels of lipid peroxides in VLDL and LDL were not different between the normal pregnant and pre-eclamptic women, and cannot account for the decrease in 6-oxo-PGF1α synthesis. VLDL, LDL and HDL from women with pre-eclampsia did not affect endothelial cell synthesis of endothelin 1 or expression of NOS3 mRNA differently from lipoproteins from normal pregnant women. This study suggests that VLDL, and to a lesser extent LDL, from women with pre-eclampsia could potentially contribute to the reduced systemic 6-oxo-PGF1α synthesis observed in the pre-eclamptic syndrome.

scholarly journals Angiotensin II causes nitric oxide synthase 3 uncoupling in the thick ascending limb

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Katherine Massey ◽  
Jagannath J. Saikumar ◽  
Mark D. Faber ◽  
Jerry J. Yee ◽  
Jeffrey L. Garvin
Keyword(s):  
Nitric Oxide ◽  
Angiotensin Ii ◽  
Nitric Oxide Synthase ◽  
Thick Ascending Limb ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase

Nitric oxide synthase 3 VNTR (intron 4 a/b) polymorphism association with diabetic nephropathy

2011 ◽  
Vol 44 (13) ◽  
pp. S270
Author(s):  
Mohseni Mahdieh Mehrab ◽  
Bazzaz Javad Tavakkoli ◽  
Shirin Hasani-Ranjbar
Keyword(s):  
Nitric Oxide ◽  
Diabetic Nephropathy ◽  
Nitric Oxide Synthase ◽  
Nitric Oxide Synthase 3 ◽  
Oxide Synthase ◽  
Intron 4
Sign in / Sign up

Export Citation Format

Share Document