Stimulation of inducible nitric oxide synthase by monosodium urate crystals in macrophages and expression of iNOS in gouty arthritis

Nitric Oxide ◽  
2004 ◽  
Vol 11 (3) ◽  
pp. 228-236 ◽  
Author(s):  
Linda Chen ◽  
Ming-Shium Hsieh ◽  
Hsin-Chiu Ho ◽  
Yung-Hung Liu ◽  
Der-Tsay Chou ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Gouty Arthritis ◽  
Monosodium Urate ◽  
Monosodium Urate Crystals ◽  
Oxide Synthase ◽  
Urate Crystals ◽  
Inducible Nitric Oxide ◽  
Stimulation Of

scholarly journals Nramp1 Functionality Increases Inducible Nitric Oxide Synthase Transcription Via Stimulation of IFN Regulatory Factor 1 Expression

2003 ◽  
Vol 171 (4) ◽  
pp. 1994-1998 ◽  
Author(s):  
Gernot Fritsche ◽  
Margit Dlaska ◽  
Howard Barton ◽  
Igor Theurl ◽  
Katja Garimorth ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Regulatory Factor ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide ◽  
Stimulation Of

Cerebellar stimulation reduces inducible nitric oxide synthase expression and protects brain from ischemia

1998 ◽  
Vol 274 (6) ◽  
pp. H2035-H2045 ◽  
Author(s):  
Elena Galea ◽  
Eugene V. Golanov ◽  
Douglas L. Feinstein ◽  
Keith A. Kobylarz ◽  
Sara B. Glickstein ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Inos Mrna ◽  
Cerebral Microvessels ◽  
Spontaneously Hypertensive ◽  
Polymerase Chain ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide ◽  
Stimulation Of

A focal infarction produced by occlusion of the middle cerebral artery (MCAO) in spontaneously hypertensive rats induced expression of inducible nitric oxide synthase (iNOS) mRNA, measured by competitive reverse transcription-polymerase chain reaction. The mRNA appeared simultaneously in the ischemic core and penumbra at 8 h, peaked between 14 and 24 h, and disappeared by 48 h. At 24 h, inducible nitric oxide synthase (iNOS)-like immunoreactivity was present in the endothelium of cerebral microvessels and in scattered cells, probably representing leukocytes or activated microglia. Electrical stimulation of the cerebellar fastigial nucleus (FN) for 1 h, 48 h before MCAO, reduced infarct volumes by 45% by decreasing cellular death in the ischemic penumbra. It also reduced by >90% the expression of iNOS mRNA and protein in the penumbra, but not core, and decreased by 44% the iNOS enzyme activity. We conclude that excitation of neuronal networks represented in the cerebellum elicits a conditioned central neurogenic neuroprotection associated with the downregulation of iNOS mRNA and protein. This neuroimmune interaction may, by blocking the expression of iNOS, contribute to neuroprotection.

Sex-specific differences in the regulation of inducible nitric oxide synthase by bisphenol A in neutrophils

2018 ◽  
Vol 38 (2) ◽  
pp. 239-246 ◽  
Author(s):  
W Ratajczak-Wrona ◽  
K Nowak ◽  
M Garley ◽  
M Tynecka ◽  
E Jablonska
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Bisphenol A ◽  
Inducible Nitric Oxide Synthase ◽  
Polymorphonuclear Neutrophils ◽  
No Production ◽  
Nuclear Fraction ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide ◽  
Stimulation Of

The aim of the study was to evaluate the effect of bisphenol A (BPA) on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression by neutrophils with regard to sex and nuclear factor-κB (NF-κB) pathway participation in this process. This study demonstrated that BPA intensifies the production of NO and the expression of iNOS in the cytoplasmic fraction of neutrophils of women as well as men. In addition, an enhanced expression of NF-κB in the cytoplasmic and nuclear fraction of neutrophils exposed to BPA was observed in the cells of both sexes. The lipopolysaccharide (LPS) stimulation of neutrophils of both sexes led to an intensification of NO production and expression of all tested proteins. However, simultaneous stimulation of neutrophils of both men and women with LPS and BPA decreased the production of NO and expression of iNOS and NF-κB in both fractions compared to the cells exposed only to xenoestrogen. Moreover, expression of iNOS and NF-κB was higher in female neutrophils than in male cells. This study demonstrated that BPA affects the production of NO with the participation of iNOS by human polymorphonuclear neutrophils. This process is associated with the activation of the NF-κB pathway. In addition, different activity of NF-κB in neutrophils, observed with respect to sex, indicates a different role of this pathway in female and male cells.

scholarly journals Stimulation of inducible nitric oxide synthase in rat liver by hyaluronan fragments

Hepatology ◽  
1998 ◽  
Vol 27 (1) ◽  
pp. 86-92 ◽  
Author(s):  
Don C. Rockey ◽  
John J. Chung ◽  
Charlotte M. McKee ◽  
Paul W. Noble
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Rat Liver ◽  
Inducible Nitric Oxide Synthase ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide ◽  
Stimulation Of
Sign in / Sign up

Export Citation Format

Share Document