MediSPECT: Single photon emission computed tomography system for small field of view small animal imaging based on a CdTe hybrid pixel detector

2007 ◽  
Vol 571 (1-2) ◽  
pp. 44-47 ◽  
Author(s):  
R. Accorsi ◽  
M. Autiero ◽  
L. Celentano ◽  
M. Chmeissani ◽  
R. Cozzolino ◽  
...  
Keyword(s):  
Single Photon ◽  
Photon Emission ◽  
Small Animal Imaging ◽  
Small Animal ◽  
Emission Computed Tomography ◽  
Pixel Detector ◽  
Tomography System ◽  
Animal Imaging ◽  
Photon Emission Computed Tomography ◽  
Small Field Of View

SMALL-ANIMAL MOLECULAR IMAGING WITH PORTABLE DEVICES ON CLINICAL PINHOLE SINGLE-PHOTON EMISSION COMPUTED TOMOGRAPHY SYSTEMS

2012 ◽  
Vol 24 (06) ◽  
pp. 485-493
Author(s):  
Chi-Min Hu ◽  
Ming-Shien Lin ◽  
Kuan-Hao Su ◽  
Ren-Shyan Liu ◽  
Jyh-Cheng Chen
Keyword(s):  
Molecular Imaging ◽  
Single Photon ◽  
Photon Emission ◽  
Small Animal ◽  
Emission Computed Tomography ◽  
Single Photon Emission ◽  
Gamma Cameras ◽  
Portable System ◽  
Single Photon Emission Computed ◽  
Photon Emission Computed Tomography

Objectives: We have developed a portable system compatible with various clinical gamma cameras to perform three-dimensional (3D) small-animal molecular imaging. The spatial resolution of this system is close to that of commercial animal imaging systems, although its cost is much lower. Methods: The portable system consists of a rotating stage, a leveling plate, a line source phantom, and a calibration phantom. To obtain high-resolution single-photon emission computed tomography (SPECT) images, we developed several methods for system alignment and applied geometric calibration. The projections of the subject were reimaged according to the calibration parameters and reconstructed by the 3D ordered subsets expectation maximization (OS-EM) algorithm. Results: The resulting images of the microdeluxe phantom showed 2.4-mm cold rods. The image quality of phantom scanning was stable when the portable system was applied to various gamma cameras from different manufacturers. The resultant images of a 99mTc-MDP bone scan of a mouse showed details of the spine, femur, pelvis, and tail. Furthermore, a radiopharmaceutical study of 99mTc-HYNIC-Annexin V on a liver inflammation-induced mouse was carried out to demonstrate the feasibility of this system for small-animal molecular imaging. Conclusions: The newly developed portable system was compatible with various gamma cameras and enabled successful performance of small-animal molecular imaging.

scholarly journals Development of a High-resolution SSR-SPECT System for Preclinical Imaging and Neuroimaging

2021 ◽  
Author(s):  
Annunziata D'Elia ◽  
Andrea Soluri ◽  
Filippo Galli ◽  
Sara Schiavi ◽  
Giselda De Silva ◽  
...  
Keyword(s):  
Spatial Resolution ◽  
Single Photon ◽  
Photon Emission ◽  
Small Animal Imaging ◽  
Small Animal ◽  
Emission Computed Tomography ◽  
Preclinical Research ◽  
Preclinical Imaging ◽  
Spect System

Abstract The utility of animal models in preclinical research has been increasing by the availability of methods for in vivo imaging. In particular, techniques like single photon emission computed tomography (SPECT) show high potential, which is usually limited by spatial resolution. This represents an important parameter influencing scanner design, given the small size of the anatomical structures to be investigated. The purpose of the present work was to assess the performance of a scintigraphic system with improved spatial resolution based on our previous detector by applying the Super Spatial Resolution (SSR). Our dual-head SPECT system is composed of gamma cameras based on the Hamamatsu H13700 position-sensitive photomultiplier tube (PSPMT). In each detector head, the PSPMT is coupled to a 28×28 array of CRY018 scintillation crystals. The pure Tungsten parallel square hole collimator ensures the position sensitivity, and a dedicated resistive chain readout so as an ADC board have been proprietary designed. To finalize the mechanical development of the SSR-SPECT system several tests were carried out. Based on the results obtained in the test phase, a partial review of the mechanical design was performed. Then a dedicated machine handling software was developed, and in particular, a kinematic software debugging and testing was assessed. Finally, several experiments were carried out by using Derenzo phantoms and capillaries filled with radioactive sources. Finally, the performance of our system was evaluated performing small animal imaging studies. The SPECT spatial resolution was experimentally determined to be about 1.6 mm. We reach a resolution of 1.18 mm by applying the SSR based on two images. The results of this study demonstrated the good capability of the system as a suitable tool for preclinical imaging especially in fields like neuroscience for the study of small brain structures.

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