MR Spectroscopy and Spectroscopic Imaging: Comparing 3.0 T versus 1.5 T

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We describe the MR spectroscopy findings in three patients with Pelizaeus-Merzbacker disease, a rare leukodystrophy associated with mutations of the PLP gene on chromosome X. The patients studied had different PLP gene mutations and presented different metabolic patterns, indicating a different phenotypic expression of mutations of the same gene.


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