PSO-ANN based diagnostic model for the early detection of dengue disease

2017 ◽  
Vol 4 (1-4) ◽  
pp. 1-8 ◽  
Author(s):  
Shalini Gambhir ◽  
Sanjay Kumar Malik ◽  
Yugal Kumar
2020 ◽  
pp. 1076-1095
Author(s):  
Shalini Gambhir ◽  
Sanjay Kumar Malik ◽  
Yugal Kumar

This article describes how Dengue fever is a fatal and hazardous disease resulting from the bite of several species of the female mosquito (principally, Aedesaegypti). Symptoms of the dengue fever mimic those of a number of other infectious and/or mosquito-borne tropical diseases such as Viral flu, Chikungunya, and Zika fever. Yet, with dengue fever, human life can be more at risk due to severe depletion of blood platelets. Thus, early detection of dengue disease can ensure saving lives; furthermore, it can help in making a preventive move before the disease progresses to epidemic proportion. Hence, the target of this article is to propose a model for an early detection and precise diagnosis of dengue disease. In this article, three prevalent machine learning methodologies, including, Artificial Neural Network (ANN), Decision Tree (DT) and Naive Bayes (NB) are evaluated for designing a diagnostic model. The performance of these models is assessed utilizing available dengue datasets. Results comparing and contrasting performance of diagnostic models utilizing accuracy, sensitivity, specificity and error rate parameters showed that ANN-based diagnostic model appears to yield better performance measures over both the DT and NB models.


Author(s):  
Shalini Gambhir ◽  
Sanjay Kumar Malik ◽  
Yugal Kumar

This article describes how Dengue fever is a fatal and hazardous disease resulting from the bite of several species of the female mosquito (principally, Aedesaegypti). Symptoms of the dengue fever mimic those of a number of other infectious and/or mosquito-borne tropical diseases such as Viral flu, Chikungunya, and Zika fever. Yet, with dengue fever, human life can be more at risk due to severe depletion of blood platelets. Thus, early detection of dengue disease can ensure saving lives; furthermore, it can help in making a preventive move before the disease progresses to epidemic proportion. Hence, the target of this article is to propose a model for an early detection and precise diagnosis of dengue disease. In this article, three prevalent machine learning methodologies, including, Artificial Neural Network (ANN), Decision Tree (DT) and Naive Bayes (NB) are evaluated for designing a diagnostic model. The performance of these models is assessed utilizing available dengue datasets. Results comparing and contrasting performance of diagnostic models utilizing accuracy, sensitivity, specificity and error rate parameters showed that ANN-based diagnostic model appears to yield better performance measures over both the DT and NB models.


2021 ◽  
Vol 4 (4) ◽  
pp. 763-770
Author(s):  
Shanty Chloranyta

ABSTRAK Deteksi Dini penyakit Dengue Haemoragic Fever di Dusun 1 Desa Sukabanjar Kecamatan Gedong Tataan Kabupaten Pesawaran Bandar Lampung belum dilakukan dengan baik di Wilayah Kerja Puskesmas Bernung. Hambatan yang ditemukan yakni pengetahuan kader kesehatan tidak adekuat, belum tersedianya informasi yang adekuat tentang deteksi dini penyakit dengue haemoragic fever (DBD) pada kader kesehatan. Pelibatan kader kesehatan dalam edukasi mengenai deteksi dini penyakit DBD menentukan keberhasilan dalam penanganan awal DBD. Tujuan kegiatan pengabdian masyarakat yang dilakukan dalam pendampingan kader kesehatan untuk meningkatkan pengetahuan dan peran kader kesehatan dalam masyarakat dalam deteksi dini DBD. Kegiatan dilakukan di Kantor Kelurahan Dusun 1 Desa Sukabanjar Kota Bandar Lampung pada bulan Desember 2018. Metode yang dilakukan yakni ceramah, diskusi, praktek cara  melakukan rumpled test. Hasil dari kegiatan pengabdian masyarakat ini didapatkan peningkatan pengetahuan kader kesehatan tentang deteksi dini DBD. Kegiatan pengabdian masyarakat yang dilakukan adalah bentuk upaya dalam deteksi dini DBD dengan melibatkan kader kesehatan. Kata Kunci : Deteksi Dini, Kader Kesehatan, Rumpled Test  ABSTRACT Early detection of dengue hemorrhagic fever in Dusun 1, Sukabanjar Village, Gedong Tataan Subdistrict, Pesawaran Regency, Bandar Lampung, has not been carried out properly in the Work Area of the Bernung Health Center. The obstacles found were inadequate knowledge of health cadres, inadequate information on early detection of dengue hemorrhagic fever (DHF) among health cadres. The involvement of health cadres in education regarding early detection of dengue disease determines the success in the initial handling of dengue. The purpose of community service activities carried out in mentoring health cadres is to increase knowledge and the role of health cadres in the community in the early detection of dengue fever. The activity was carried out at the Subdistrict Office of Dusun 1, Sukabanjar Village, Bandar Lampung City in December 2018. The methods used were lectures, discussions, practice on how to do a rumpled test. The results of this community service activity were found to increase the knowledge of health cadres about the early detection of dengue. Community service activities carried out are a form of effort in early detection of dengue by involving health cadres. Keyword: early detection, Health cadres, rumpled test


2021 ◽  
Vol 4 (4) ◽  
pp. 763-770
Author(s):  
Shanty Chloranyta

ABSTRAK Deteksi Dini penyakit Dengue Haemoragic Fever di Dusun 1 Desa Sukabanjar Kecamatan Gedong Tataan Kabupaten Pesawaran Bandar Lampung belum dilakukan dengan baik di Wilayah Kerja Puskesmas Bernung. Hambatan yang ditemukan yakni pengetahuan kader kesehatan tidak adekuat, belum tersedianya informasi yang adekuat tentang deteksi dini penyakit dengue haemoragic fever (DBD) pada kader kesehatan. Pelibatan kader kesehatan dalam edukasi mengenai deteksi dini penyakit DBD menentukan keberhasilan dalam penanganan awal DBD. Tujuan kegiatan pengabdian masyarakat yang dilakukan dalam pendampingan kader kesehatan untuk meningkatkan pengetahuan dan peran kader kesehatan dalam masyarakat dalam deteksi dini DBD. Kegiatan dilakukan di Kantor Kelurahan Dusun 1 Desa Sukabanjar Kota Bandar Lampung pada bulan Desember 2018. Metode yang dilakukan yakni ceramah, diskusi, praktek cara  melakukan rumpled test. Hasil dari kegiatan pengabdian masyarakat ini didapatkan peningkatan pengetahuan kader kesehatan tentang deteksi dini DBD. Kegiatan pengabdian masyarakat yang dilakukan adalah bentuk upaya dalam deteksi dini DBD dengan melibatkan kader kesehatan. Kata Kunci : Deteksi Dini, Kader Kesehatan, Rumpled Test  ABSTRACT Early detection of dengue haemoragic fever in Dusun 1, Sukabanjar Village, Gedong Tataan Subdistrict, Pesawaran Regency, Bandar Lampung, has not been carried out properly in the Work Area of the Bernung Health Center. The obstacles found were inadequate knowledge of health cadres, inadequate information on early detection of dengue haemorrhagic fever (DHF) among health cadres. The involvement of health cadres in education regarding early detection of dengue disease determines the success in the initial handling of dengue. The purpose of community service activities carried out in mentoring health cadres is to increase knowledge and the role of health cadres in the community in early detection of dengue fever. The activity was carried out at the Subdistrict Office of Dusun 1, Sukabanjar Village, Bandar Lampung City in December 2018. The methods used were lectures, discussions, practice on how to do a rumpled test. The results of this community service activity were found to increase the knowledge of health cadres about the early detection of dengue. Community service activities carried out are a form of effort in early detection of dengue by involving health cadres. Keyword : early detection, Health cadres, rumpled test


Author(s):  
Debashree Devi ◽  
Saroj K. Biswas ◽  
Biswajit Purkayastha

Parkinson's disease (PD) is a neurodegenerative disorder that occurs due to corrosion of the substantia nigra, located in the thalamic region of the human brain, and is responsible for transmission of neural signals throughout the human body by means of a brain chemical, termed as “dopamine.” Diagnosis of PD is difficult, as it is often affected by the characteristics of the medical data of the patients, which include presence of various indicators, imbalance cases of patients' data records, similar cases of healthy/affected persons, etc. Through this chapter, an intelligent diagnostic system is proposed by integrating one-class SVM, extreme learning machine, and data preprocessing technique. The proposed diagnostic model is validated with six existing techniques and four learning models. The experimental results prove the combination of proposed method with ELM learning model to be highly effective in case of early detection of Parkinson's disease, even in presence of underlying data issues.


2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Nooshin Dalili ◽  
Shiva Kalantari ◽  
Mohsen Nafar

Abstract Background and Aims Contrast induced nephropathy (CIN) has been reported to be the third foremost cause of acute renal failure. Metabolomics is a robust technique that has been used to identify potential biomarkers for early detection of renal damage after procedures with using contrast media. We aim to analyze the serum and urine metabolites changes, after using contrast for coronary angiography, to determine if metabolomics can use as a tool for early detection of CIN. Method Sixty-six patients with positive primary non-invasive diagnostic tests for coronary artery disease (CAD) who were candidate of elective coronary angiography recruited. Spot urine samples collected in the morning before angiography and 4 hours after angiography. Patients with > 0.5 mg/dL creatinine rise compared to baseline were considered as case (CIN group). Urine samples were centrifuged at 3000 rcf for 20 minutes at 4°C to remove the cell debris and after addition of sodium azide to prevent bacterial growth, were stored at -80 degree Celsius in aliquots until required. The mixtures were then transferred to a standard 5 mm NMR tube for analysis. 1H-NMR spectra were acquired at 300 K on a Bruker DRX 500 MHz spectrometer by using Carr–Pucell–Meiboom–Gill (CPMG) technique. For each spectrum, 154 scans were collected into 32K data points using a spectral width of 8389.26 Hz during the relaxation time of 2.5 s. Results Structure and outliers of the dataset composed of patient with CIN (n = 10) before angiography and after angiography were evaluated by PCA. A model with two principal components (PC1 and PC2) with R2X = 0.775 and Q2(cum) = 0.487 was obtained .A supervised OPLS-DA model was built to identify discriminative variables between metabolite profiles before and after angiography in patients with CIN. The high level of AUC 0.95 that was obtained from 10-fold cross validation besides decreased R2 (0.0, 0.415) and Q2 (0.0, -0.454) intercepts of 999 random permutations reflects the good validity of this diagnostic model. According to this valid OPLS-DA model, 15 chemical shifts were significant based on VIP > 1 and FC > 1.2. To check these suggested chemical shifts if their changes are due to kidney injury and not caused by contrast agent, a decoy OPLS-DA model was built for non-CIN patients before and after angiography .Two common significant chemical shifts (2.42 and 2.78 ppm) were found in comparison of these two models (i.e. before vs. after angiography in CIN group in compared with before vs. after angiography in non-CIN group) and were excluded from the results. Metabolites corresponding with the remaining list of 12 significant chemical shifts were identified and suggested as early detection biomarker candidates for CIN (Fig 1). The AUC value of a panel of four biomarker candidates were higher than single biomarkers that reflects the value of simultaneous measurement of these four metabolite candidates than single candidates. Figure 2 shows the list of diagnostic metabolite candidates with p < 0.05 . Pathway characterization was used to better understanding of pathophysiology of CIN. As the input data was small list of metabolites, only “Histidine_ lysine_ phenylalanine, tyrosine, proline and tryptophan catabolism” pathway (p < 0.05) was significant and suggested as the most important disturbed pathway in CIN. Conclusion Early detection of CIN as early as only 4 hours after using contrast can help better management of these patients. In this study, only after 4 hours passed from using contrast a panel of metabolites could be found in urine of patients who develop CIN, which facilitates early detection of CIN. This is the first study to investigate urine metabolic profile using NMR-based metabolomics for early detection of CIN after coronary angiography. The use of this suggested panel might significantly improve clinical consequences of this harmful complication.


Gut ◽  
2019 ◽  
Vol 68 (12) ◽  
pp. 2195-2205 ◽  
Author(s):  
Jiabin Cai ◽  
Lei Chen ◽  
Zhou Zhang ◽  
Xinyu Zhang ◽  
Xingyu Lu ◽  
...  

ObjectiveThe lack of highly sensitive and specific diagnostic biomarkers is a major contributor to the poor outcomes of patients with hepatocellular carcinoma (HCC). We sought to develop a non-invasive diagnostic approach using circulating cell-free DNA (cfDNA) for the early detection of HCC.DesignApplying the 5hmC-Seal technique, we obtained genome-wide 5-hydroxymethylcytosines (5hmC) in cfDNA samples from 2554 Chinese subjects: 1204 patients with HCC, 392 patients with chronic hepatitis B virus infection (CHB) or liver cirrhosis (LC) and 958 healthy individuals and patients with benign liver lesions. A diagnostic model for early HCC was developed through case-control analyses using the elastic net regularisation for feature selection.ResultsThe 5hmC-Seal data from patients with HCC showed a genome-wide distribution enriched with liver-derived enhancer marks. We developed a 32-gene diagnostic model that accurately distinguished early HCC (stage 0/A) based on the Barcelona Clinic Liver Cancer staging system from non-HCC (validation set: area under curve (AUC)=88.4%; (95% CI 85.8% to 91.1%)), showing superior performance over α-fetoprotein (AFP). Besides detecting patients with early stage or small tumours (eg, ≤2.0 cm) from non-HCC, the 5hmC model showed high capacity for distinguishing early HCC from high risk subjects with CHB or LC history (validation set: AUC=84.6%; (95% CI 80.6% to 88.7%)), also significantly outperforming AFP. Furthermore, the 5hmC diagnostic model appeared to be independent from potential confounders (eg, smoking/alcohol intake history).ConclusionWe have developed and validated a non-invasive approach with clinical application potential for the early detection of HCC that are still surgically resectable in high risk individuals.


2021 ◽  
Author(s):  
B Chitra ◽  
S.S. Kumar

Abstract The cervical cancer patient’s death rate can be minimized by accurate and early detection of cervical cancer (CC). One of the popular techniques called the Pap test or Pap smear is widely used for the early detection of CC. The manual analysis consumed more time in the case of CC detection. The existing techniques met few shortcomings in terms of poor accuracy, more computational complexity, higher feature dimensionality, poor reliability, and higher time-consumption with poor hyperparameters optimization. Hence, the computer-aided diagnostic model provides reliable and accurate CC detection at the initial stage. In this paper, we proposed MASO optimized DenseNet 121 architecture for the early detection of cervical cancer. At first, different kinds of augmentation techniques such as horizontal flip, vertical flip, zooming, shearing, height shift, width shift, rotation, and brightness to increase the number of training samples. The Mutation based Atom Search Optimization (MASO) algorithm is established to optimize the hyperparameters in DenseNet 121 architecture suchnumber of neurons in the dense layer, learning rate value, and the batch sizes. Different kinds of performance metrics such as accuracy, specificity, sensitivity, precisions, recall, F-score, and confusion matrix evaluate the performance of MASO optimized DenseNet 121 architecture for CC detection. A single normal class with three abnormal classes namely Carcinoma, Light dysplastic, and Sever dysplastic were selected from the Hervel dataset for experimental investigation. The proposed MASO optimized DenseNet 121 architecture achieves 98.38% accuracy, 98.5% specificity, 98.83% sensitivity, 98.58% precision, 99.3% recall and 98.25% F-score values than other existing methods.


Author(s):  
Mohamed M. Omran ◽  
Sara Mosaad ◽  
Tarek M. Emran ◽  
Fathy M. Eltaweel ◽  
Khaled Farid

Abstract Background The coexistence of cirrhosis complicates the early detection of hepatocellular carcinoma (HCC). Thus, novel biomarkers for HCC early detection are needed urgently. Traditionally, HCC detection is carried out by evaluating alpha-fetoprotein (AFP) levels combined with imaging techniques. This work aimed to assess interleukin (IL-6) and insulin-like growth factor 2 (IGF 2) as possible HCC markers in comparison to AFP in patients with and without HCC. Results ROC analysis showed that IGF2 had the highest area under the curve (AUC) for discriminating HCC from liver cirrhosis (0.86), followed by IL6 (0.82), AFP (0.72), and platelet count (0.6). A four-marker model was developed and discriminated HCC from liver cirrhosis with an AUC of 0.97. The best cut-off was 1.28, at which sensitivity and specificity were 90% and 85%, respectively. For small tumor (< 2 cm), the model had an AUC of 0.95 compared to AFP (0.72). Also, the model achieved perfect performance with AUC of 0.93, 0.94, and 0.95 for BCLC (0-A), CLIP (0-1), and Okuda (stage I), respectively, compared to AFP (AUC of 0.71, 0.69, and 0.67, respectively). Conclusions The four markers may serve as a diagnostic model for HCC early stages and help overcome AFP poor sensitivity.


Sign in / Sign up

Export Citation Format

Share Document