scholarly journals Differential Regulation of Evoked and Spontaneous Release by Presynaptic NMDA Receptors

Neuron ◽  
2017 ◽  
Vol 96 (4) ◽  
pp. 839-855.e5 ◽  
Author(s):  
Therése Abrahamsson ◽  
Christina You Chien Chou ◽  
Si Ying Li ◽  
Adamo Mancino ◽  
Rui Ponte Costa ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
Differential Regulation ◽  
Spontaneous Release ◽  
Presynaptic Nmda Receptors

scholarly journals Searching for Presynaptic NMDA Receptors in the Nucleus Accumbens

2011 ◽  
Vol 31 (50) ◽  
pp. 18453-18463 ◽  
Author(s):  
Y. H. Huang ◽  
M. Ishikawa ◽  
B. R. Lee ◽  
N. Nakanishi ◽  
O. M. Schluter ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Nmda Receptors ◽  
Presynaptic Nmda Receptors

Visual stimuli–induced LTD of GABAergic synapses mediated by presynaptic NMDA receptors

2006 ◽  
Vol 9 (3) ◽  
pp. 372-380 ◽  
Author(s):  
Cheng-Chang Lien ◽  
Yangling Mu ◽  
Mariana Vargas-Caballero ◽  
Mu-ming Poo
Keyword(s):  
Nmda Receptors ◽  
Visual Stimuli ◽  
Gabaergic Synapses ◽  
Presynaptic Nmda Receptors

Differential regulation of synaptic and extra-synaptic NMDA receptors

10.1038/nn912 ◽  
2002 ◽  
Vol 5 (9) ◽  
pp. 833-834 ◽  
Author(s):  
Bo Li ◽  
Nansheng Chen ◽  
Tao Luo ◽  
Yo Otsu ◽  
Timothy H. Murphy ◽  
...  
Keyword(s):  
Nmda Receptors ◽  
Differential Regulation

scholarly journals Presynaptic NMDA receptors facilitate short-term plasticity and BDNF release at hippocampal mossy fiber synapses

eLife ◽  
2021 ◽  
Vol 10 ◽  
Author(s):  
Pablo J Lituma ◽  
Hyung-Bae Kwon ◽  
Karina Alviña ◽  
Rafael Luján ◽  
Pablo E Castillo
Keyword(s):  
Nmda Receptors ◽  
Information Transfer ◽  
Mossy Fiber ◽  
Pyramidal Cells ◽  
Synaptic Function ◽  
Fine Tuning ◽  
Short Term ◽  
Dentate Granule Cell ◽  
Presynaptic Calcium ◽  
Presynaptic Nmda Receptors

Neurotransmitter release is a highly controlled process by which synapses can critically regulate information transfer within neural circuits. While presynaptic receptors –typically activated by neurotransmitters and modulated by neuromodulators– provide a powerful way of fine-tuning synaptic function, their contribution to activity-dependent changes in transmitter release remains poorly understood. Here, we report that presynaptic NMDA receptors (preNMDARs) at mossy fiber boutons in the rodent hippocampus can be activated by physiologically relevant patterns of activity and selectively enhance short-term synaptic plasticity at mossy fiber inputs onto CA3 pyramidal cells and mossy cells, but not onto inhibitory interneurons. Moreover, preNMDARs facilitate brain-derived neurotrophic factor (BDNF) release and contribute to presynaptic calcium rise. Taken together, our results indicate that by increasing presynaptic calcium, preNMDARs fine tune mossy fiber neurotransmission and can control information transfer during dentate granule cell burst activity that normally occur in vivo.

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