scholarly journals Coupled Control of Desensitization and Gating by the Ligand Binding Domain of Glutamate Receptors

Neuron ◽  
2012 ◽  
Vol 74 (5) ◽  
pp. 845-857 ◽  
Author(s):  
Anna L. Carbone ◽  
Andrew J.R. Plested
Keyword(s):  
Ligand Binding ◽  
Glutamate Receptors ◽  
Binding Domain ◽  
Ligand Binding Domain

How well can molecular modelling predict the crystal structure: the case of the ligand-binding domain of glutamate receptors

2000 ◽  
Vol 21 (3) ◽  
pp. 87-92 ◽  
Author(s):  
Yoav Paas ◽  
Anne Devillers-Thiéry ◽  
Vivian I Teichberg ◽  
Jean-Pierre Changeux ◽  
Miriam Eisenstein
Keyword(s):  
Crystal Structure ◽  
Ligand Binding ◽  
Glutamate Receptors ◽  
Molecular Modelling ◽  
Binding Domain ◽  
Ligand Binding Domain

The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins

Neuron ◽  
1993 ◽  
Vol 11 (1) ◽  
pp. 41-52 ◽  
Author(s):  
Patrick J. O'Hara ◽  
Paul O. Sheppard ◽  
Henning Thógersen ◽  
Domenick Venezia ◽  
Betty A. Haldeman ◽  
...  
Keyword(s):  
Ligand Binding ◽  
Glutamate Receptors ◽  
Metabotropic Glutamate Receptors ◽  
Binding Proteins ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Metabotropic Glutamate ◽  
Periplasmic Binding Proteins

scholarly journals Ionotropic Glutamate Receptors (iGluRs): Overview of iGluR2 ligand binding domain in complex with agonists and antagonists

2011 ◽  
Vol 57 ◽  
pp. 3-16
Author(s):  
Zorica Serafimoska ◽  
Tommy N. Johansen ◽  
Karla Frydenvang ◽  
Ljubica Suturkova
Keyword(s):  
Ligand Binding ◽  
Glutamate Receptors ◽  
Brain Function ◽  
Structural Information ◽  
Binding Domain ◽  
Ligand Binding Domain ◽  
Ionotropic Glutamate Receptors ◽  
Normal Brain ◽  
Partial Agonists ◽  
Normal Brain Function

Ionotropic glutamate receptors (iGluRs) constitute a family of ligand gated ion channels subdivided in three classes, NMDA, AMPA (iGluA1-4) and KA (1-5) according to the agonists that selectively activate them. iGluRs are tetrameric assemblies of highly homologous receptor subunits. They are critically important for normal brain function and are considered to be involved on neurological disorders and degenerative diseases such as schizophrenia, Alzheimer’s disease, brain damage following stroke and epilepsy. Since the first publication of the structure of recombinant soluble protein of ligand binding domain of GluA2 extensive studies on this group of receptors were performed and many crystal structures as complexes of GluA2-LBD with agonists, partial agonists and antagonists were obtained. The structural information in combination with functional data makes good platform for consecutive investigation and design of new selective drugs which will be used in treatment of neurodegerative diseases.

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