scholarly journals Distinct Modes of AMPA Receptor Suppression at Developing Synapses by GluN2A and GluN2B: Single-Cell NMDA Receptor Subunit Deletion In Vivo

Neuron ◽  
2011 ◽  
Vol 71 (6) ◽  
pp. 1085-1101 ◽  
Author(s):  
John A. Gray ◽  
Yun Shi ◽  
Hiroshi Usui ◽  
Matthew J. During ◽  
Kenji Sakimura ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Single Cell ◽  
Ampa Receptor ◽  
Receptor Subunit ◽  
Nmda Receptor Subunit

Electroacupuncture ameliorates CUMS-induced depression-like behavior: involvement of the glutamatergic system and apoptosis in rats

2020 ◽  
Vol 23 ◽  
Author(s):  
Qin Guo ◽  
Xian-Ming Lin ◽  
Zhong Di ◽  
Quan-Ai Zhang ◽  
Shuo Jiang
Keyword(s):  
Nmda Receptor ◽  
Caspase 3 ◽  
B Cell Lymphoma ◽  
Sucrose Preference ◽  
Expression Level ◽  
Receptor Subunit ◽  
Glutamatergic System ◽  
Ionotropic Receptor ◽  
Nmda Receptor Subunit ◽  
Expression Levels

Background: Converging evidence indicates that glutamatergic system and glia are directly implicated in the pathophysiology of depression. Clinical studies indicate that electroacupuncture (EA) has antidepressant-like effect with low side effects for depression. However, the underlying antidepressant mechanism of acupuncture remains obscure. Methods: Chronic unpredictable mild stress (CUMS)-induced depressive rats were used to induce depressive-like behavior, and evaluated by the weight change, open field test, sucrose preference test, and novelty suppressed feeding test. EA, NMDA receptor subunit 2A antagonist (NR2A RA) or NMDA receptor subunit 2B antagonist (NR2B RA) was used for comparison. High performance liquid chromatography (HPLC) was performed to detect the content of hippocampal glutamate, while western blot for the hippocampal protein expression levels of calcium/calmodulin-dependent protein kinase II (CaMKII), Bax, caspase 3 and B-cell lymphoma-2 (Bcl-2). The distribution of glutamate ionotropic receptor NMDA type subunit 2A (NR2A), neuronal nuclear protein (NeuN), glutamate ionotropic receptor NMDA type subunit 2B (NR2B) and glial fibrillary acidic protein (GFAP) were detected by immunofluorescence. Results: Significant depression behavior (reduced body weight and sucrose preference, increased feeding and immobility time) was produced in CUMS-induced depressive rats, which was reversed significantly by EA. EA decreased hippocampal glutamate level. EA led to a significant decrease in expression levels of Bax, caspase 3 and CaMKⅡ accompanied by increased Bcl-2 expression level. Furthermore, EA significantly increased NR2A expression level as well as decreased NR2B expression level in hippocampus. Conclusion: EA ameliorated depression-like behavior in CUMS rats, which might be mediated, at least in part, by regulating the glutamate, NMDA receptors and apoptosis in the hippocampus.

Repeated cocaine administration differentially affects NMDA receptor subunit (NR1, NR2A-C) mRNAs in rat brain

Synapse ◽  
2002 ◽  
Vol 46 (3) ◽  
pp. 157-169 ◽  
Author(s):  
Mika Yamaguchi ◽  
Toshihito Suzuki ◽  
Shuzo Abe ◽  
Takafumi Hori ◽  
Hirofumi Kurita ◽  
...  
Keyword(s):  
Nmda Receptor ◽  
Rat Brain ◽  
Receptor Subunit ◽  
Nmda Receptor Subunit ◽  
Cocaine Administration

scholarly journals Isoflurane/nitrous oxide anesthesia induces increases in NMDA receptor subunit NR2B protein expression in the aged rat brain

2012 ◽  
Vol 1431 ◽  
pp. 23-34 ◽  
Author(s):  
Lana J. Mawhinney ◽  
Juan Pablo de Rivero Vaccari ◽  
Ofelia F. Alonso ◽  
Christopher A. Jimenez ◽  
Concepción Furones ◽  
...  
Keyword(s):  
Nitrous Oxide ◽  
Nmda Receptor ◽  
Protein Expression ◽  
Rat Brain ◽  
Receptor Subunit ◽  
Nmda Receptor Subunit ◽  
Aged Rat ◽  
Oxide Anesthesia
Sign in / Sign up

Export Citation Format

Share Document