Enteric glial reactivity to systemic LPS administration: Changes in GFAP and S100B protein

2017 ◽  
Vol 119 ◽  
pp. 15-23 ◽  
Author(s):  
Raphaela da Cunha Franceschi ◽  
Patrícia Nardin ◽  
Clivia Valle Machado ◽  
Lucas Silva Tortorelli ◽  
Malcon Andrei Martinez-Pereira ◽  
...  
Keyword(s):  
S100b Protein ◽  
Glial Reactivity

Impact of routine S100B protein assay on CT scan use in children with mild traumatic brain injury

2020 ◽  
Vol 0 (0) ◽  
Author(s):  
Fleur Lorton ◽  
Jeanne Simon-Pimmel ◽  
Damien Masson ◽  
Elise Launay ◽  
Christèle Gras-Le Guen ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
University Hospital ◽  
S100b Protein ◽  
Research Network ◽  
Ct Scans ◽  
Intermediate Risk ◽  
Protein Assay ◽  
The Impact

AbstractObjectivesTo evaluate the impact of implementing a modified Pediatric Emergency Care Applied Research Network (PECARN) rule including the S100B protein assay for managing mild traumatic brain injury (mTBI) in children.MethodsA before-and-after study was conducted in a paediatric emergency department of a French University Hospital from 2013 to 2015. We retrospectively included all consecutive children aged 4 months to 15 years who presented mTBI and were at intermediate risk for clinically important traumatic brain injury (ciTBI). We compared the proportions of CT scans performed and of in-hospital observations before (2013–2014) and after (2014–2015) implementation of a modified PECARN rule including the S100B protein assay.ResultsWe included 1,062 children with mTBI (median age 4.5 years, sex ratio [F/M] 0.73) who were at intermediate risk for ciTBI: 494 (46.5%) during 2013–2014 and 568 (53.5%) during 2014–2015. During 2014–2015, S100B protein was measured in 451 (79.4%) children within 6 h after mTBI. The proportion of CT scans and in-hospital observations significantly decreased between the two periods, from 14.4 to 9.5% (p=0.02) and 73.9–40.5% (p<0.01), respectively. The number of CT scans performed to identify a single ciTBI was reduced by two-thirds, from 18 to 6 CT scans, between 2013–2014 and 2014–2015. All children with ciTBI were identified by the rules.ConclusionsThe implementation of a modified PECARN rule including the S100B protein assay significantly decreased the proportion of CT scans and in-hospital observations for children with mTBI who were at intermediate risk for ciTBI.

Increased S100B Levels in Cannabis Use Disorder

2015 ◽  
Vol 22 (4) ◽  
pp. 177-180 ◽  
Author(s):  
Huseyin Bayazit ◽  
Erdinc Cicek ◽  
Salih Selek ◽  
Nurten Aksoy ◽  
I. Fatih Karababa ◽  
...  
Keyword(s):  
Calcium Binding ◽  
Neuronal Damage ◽  
Cannabis Use ◽  
S100b Protein ◽  
Control Group ◽  
Blood Levels ◽  
Cannabis Use Disorder ◽  
Protein Levels ◽  
S100 Calcium Binding Protein ◽  
The Mean

Background: It has been determined that cannabis has adverse effects on brain tissue, and that increased S100 calcium binding protein B (S100B) blood levels are markers of neuronal damage. Therefore, the aim of this study was to evaluate the S100B levels in cannabis use disorder. Method: Thirty-two patients with cannabis use disorder and 31 matched healthy controls were enrolled in this study. Appropriate blood samples were taken from the enrolled subjects, and the serum S100B protein levels were measured with an electrochemiluminescence immunoassay for the quantification of the protein. Findings: We found significantly increased S100B protein levels in patients with cannabis use disorder. The mean serum concentration of S100B was 0.081 ± 0.018 μg/l in patients with cannabis use disorder, and 0.069 ± 0.018 μg/l in the control group (p = 0.008). Interpretation: Our data suggest that elevated S100B protein levels might indicate neuronal damage in the brains of people with cannabis use disorder.

scholarly journals The multiple faces of inflammatory enteric glial cells: is Crohn’s disease a gliopathy?

2018 ◽  
Vol 315 (1) ◽  
pp. G1-G11 ◽  
Author(s):  
Camille Pochard ◽  
Sabrina Coquenlorge ◽  
Marie Freyssinet ◽  
Philippe Naveilhan ◽  
Arnaud Bourreille ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Glial Cells ◽  
Physiological Role ◽  
Enteric Neurons ◽  
Intestinal Epithelial ◽  
Intestinal Epithelial Barrier ◽  
Enteric Glial Cells ◽  
Glial Reactivity

Gone are the days when enteric glial cells (EGC) were considered merely satellites of enteric neurons. Like their brain counterpart astrocytes, EGC express an impressive number of receptors for neurotransmitters and intercellular messengers, thereby contributing to neuroprotection and to the regulation of neuronal activity. EGC also produce different soluble factors that regulate neighboring cells, among which are intestinal epithelial cells. A better understanding of EGC response to an inflammatory environment, often referred to as enteric glial reactivity, could help define the physiological role of EGC and the importance of this reactivity in maintaining gut functions. In chronic inflammatory disorders of the gut such as Crohn’s disease (CD) and ulcerative colitis, EGC exhibit abnormal phenotypes, and their neighboring cells are dysfunctional; however, it remains unclear whether EGC are only passive bystanders or active players in the pathophysiology of both disorders. The aim of the present study is to review the physiological roles and properties of EGC, their response to inflammation, and their role in the regulation of the intestinal epithelial barrier and to discuss the emerging concept of CD as an enteric gliopathy.

In vivo LPS administration alters S100B protein content in cerebrospinal fluid, but not in serum

2012 ◽  
Vol 18 (2) ◽  
pp. 54-55
Author(s):  
Lucas Silva Tortorelli ◽  
Maria Cristina Guerra ◽  
Fabiana Galland ◽  
Carollina Da Ré ◽  
Elisa Negri ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Protein Content ◽  
S100b Protein

728 Effect of Enteroglial-Derived S100B Protein on Human Peripheral and Mucosal Immune Cells' Functions

2010 ◽  
Vol 138 (5) ◽  
pp. S-98
Author(s):  
Carla Cirillo ◽  
Giovanni Sarnelli ◽  
Elena D'Aiuto ◽  
Annamaria Mango ◽  
Fabio Turco ◽  
...  
Keyword(s):  
Immune Cells ◽  
S100b Protein

Serum S100B Protein Could Help to Detect Cerebral Complications Associated with Extracorporeal Membrane Oxygenation (ECMO)

2013 ◽  
Vol 20 (3) ◽  
pp. 367-374 ◽  
Author(s):  
Duc Nam Nguyen ◽  
Luc Huyghens ◽  
Francis Wellens ◽  
Johan Schiettecatte ◽  
Johan Smitz ◽  
...  
Keyword(s):  
Extracorporeal Membrane Oxygenation ◽  
S100b Protein ◽  
Serum S100b ◽  
Membrane Oxygenation ◽  
Cerebral Complications

Is S100B protein level really not an indicator of brain damage due to carbon monoxide poisoning in children?

2013 ◽  
Vol 31 (10) ◽  
pp. 1531 ◽  
Author(s):  
Yusuf Emrah Eyi ◽  
Yakup Aksoy ◽  
Emre Zorlu ◽  
Abdullah Kaya ◽  
Kadir Ozturk ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Brain Damage ◽  
Protein Level ◽  
Carbon Monoxide Poisoning ◽  
S100b Protein ◽  
Poisoning In Children

Associations between Circulating Serum S100b Protein and Symptoms of Anxiety and Depression in Obese Children.

2010 ◽  
pp. P2-714-P2-714
Author(s):  
P Pervanidou ◽  
D Bastaki ◽  
C Kariyannis ◽  
C Kanaka-Gantenbein ◽  
K Papanikolaou ◽  
...  
Keyword(s):  
S100b Protein ◽  
Anxiety And Depression ◽  
Obese Children ◽  
Serum S100b
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