Activity-dependent regulation of synaptic vesicle exocytosis and presynaptic short-term plasticity

2011 ◽  
Vol 70 (1) ◽  
pp. 16-23 ◽  
Author(s):  
Sumiko Mochida
Keyword(s):  
Synaptic Vesicle ◽  
Short Term ◽  
Short Term Plasticity ◽  
Synaptic Vesicle Exocytosis ◽  
Vesicle Exocytosis ◽  
Activity Dependent

scholarly journals Role of specific presynaptic calcium channel subtypes in isoflurane inhibition of synaptic vesicle exocytosis in rat hippocampal neurones

2019 ◽  
Vol 123 (2) ◽  
pp. 219-227 ◽  
Author(s):  
Yuko Koyanagi ◽  
Christina L. Torturo ◽  
Daniel C. Cook ◽  
Zhenyu Zhou ◽  
Hugh C. Hemmings
Keyword(s):  
Calcium Channel ◽  
Synaptic Vesicle ◽  
Synaptic Vesicle Exocytosis ◽  
Vesicle Exocytosis ◽  
Presynaptic Calcium

scholarly journals SNARE Complex Oligomerization by Synaphin/Complexin Is Essential for Synaptic Vesicle Exocytosis

Cell ◽  
2001 ◽  
Vol 104 (3) ◽  
pp. 421-432 ◽  
Author(s):  
Hiroshi Tokumaru ◽  
Keiko Umayahara ◽  
Lorenzo L Pellegrini ◽  
Toru Ishizuka ◽  
Hideo Saisu ◽  
...  
Keyword(s):  
Synaptic Vesicle ◽  
Snare Complex ◽  
Synaptic Vesicle Exocytosis ◽  
Vesicle Exocytosis

scholarly journals Diurnal Changes in Exocytosis and the Number of Synaptic Ribbons at Active Zones of an on-Type Bipolar Cell Terminal

2006 ◽  
Vol 96 (4) ◽  
pp. 2025-2033 ◽  
Author(s):  
Court Hull ◽  
Keith Studholme ◽  
Stephen Yazulla ◽  
Henrique von Gersdorff
Keyword(s):  
Synaptic Vesicle ◽  
Bipolar Cell ◽  
Bipolar Cells ◽  
Synaptic Ribbons ◽  
Diurnal Changes ◽  
Synaptic Vesicle Exocytosis ◽  
Pulse Ratio ◽  
Vesicle Exocytosis ◽  
Active Zones ◽  
Vesicle Pool

The number and morphology of synaptic ribbons at photoreceptor and bipolar cell terminals has been reported to change on a circadian cycle. Here we sought to determine whether this phenomenon exists at goldfish Mb-type bipolar cell terminals with the aim of exploring the role of ribbons in transmitter release. We examined the physiology and ultrastructure of this terminal around two time points: midday and midnight. Nystatin perforated-patch recordings of membrane capacitance ( Cm) revealed that synaptic vesicle exocytosis evoked by short depolarizations was reduced at night, even though Ca2+ currents were larger. The efficiency of exocytosis (measured as the Δ Cm jump per total Ca2+ charge influx) was thus significantly lower at night. The paired-pulse ratio remained unchanged, however, suggesting that release probability was not altered. Hence the decreased exocytosis likely reflects a smaller readily releasable vesicle pool at night. Electron microscopy of single sections from intact retinas averaged 65% fewer ribbons at night. Interestingly, the number of active zones did not change from day to night, only the probability of finding a ribbon at an active zone. Additionally, synaptic vesicle halos surrounding the ribbons were more completely filled at night when these on-type bipolar cells are more hyperpolarized. There was no change, however, in the physical dimensions of synaptic ribbons from day to night. These results suggest that the size of the readily releasable vesicle pool and the efficiency of exocytosis are reduced at night when fewer ribbons are present at bipolar cell terminal active zones.

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