Protective effect of carnosine on white matter damage in corpus striatum induced by chronic cerebral hypoperfusion

2018 ◽  
Vol 683 ◽  
pp. 54-60 ◽  
Author(s):  
Jing Ma ◽  
Haijing Yan ◽  
Ranran Wang ◽  
Shuhong Bo ◽  
Xiaotong Lu ◽  
...  
Keyword(s):  
White Matter ◽  
Protective Effect ◽  
Corpus Striatum ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
White Matter Damage

scholarly journals The protective effect of Thai Herbal Sahatsatara formula against white matter injury after chronic cerebral hypoperfusion in middle-aged rats

ScienceAsia ◽  
2020 ◽  
Vol 46 (6) ◽  
pp. 713
Author(s):  
Saruda Kuraeiad ◽  
Anchalee Vattarakorn ◽  
Onusa Thamsermsang ◽  
Pravit Akarasereenont ◽  
Sompol Tapechum ◽  
...  
Keyword(s):  
White Matter ◽  
Protective Effect ◽  
Chronic Cerebral Hypoperfusion ◽  
White Matter Injury ◽  
Cerebral Hypoperfusion ◽  
Aged Rats ◽  
Middle Aged

scholarly journals Comprehensive Evaluation of White Matter Damage and Neuron Death and Whole-Transcriptome Analysis of Rats With Chronic Cerebral Hypoperfusion

2019 ◽  
Vol 13 ◽  
Author(s):  
Wenxian Li ◽  
Di Wei ◽  
Jianye Liang ◽  
Xiaomei Xie ◽  
Kangping Song ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Neuronal Death ◽  
Chronic Cerebral Hypoperfusion ◽  
Differentially Expressed ◽  
Cerebral Hypoperfusion ◽  
Neuron Death ◽  
White Matter Damage ◽  
Morris Water Maze Task ◽  
Whole Transcriptome

Background/AimsChronic cerebral hypoperfusion (CCH) is induced by chronic deficit of brain perfusion, contributes to a persistent or progressive cognitive dysfunction, which is characterized by diverse neuropathological manifestations. There are currently no effective medications available. White matter damage (WMD) and cortical neuron death may be caused by CCH, which are related to cognitive impairment, while the underlying molecular mechanisms remain unclear. In the study, a database of the transcriptome level was built to determine potential biomarkers in cortex of CCH.MethodsCCH was induced in male Sprague-Dawley rats by permanent occlusion of the bilateral common carotid arteries. Rats were randomly divided into three groups: Sham-operated group (n = 24), the 4th and 8th week of CCH groups (total = 56, n = 28 for each group). Cognitive function was evaluated using the Morris water maze task. WMD and neuron damage were detected using diffusion tensor imaging and histological analysis, respectively. Western blotting analysis of various markers was used to examine neuronal death. Whole-transcriptome microarray was performed to assess mRNA, circRNA, and lncRNA expression profiles at 4th and 8th weeks after CCH. Diversified bioinformatic tools were performed to analyze and predict the key biological processes and signaling pathways of differentially expressed RNAs and co-expressed potential target genes. Co-expression networks of mRNA–circRNA–miRNA and lncRNA–mRNA were constructed.ResultsCompared to the sham group, cognitive impairment, disintegration of white matter, blood-brain barrier damage and neuron death were induced by CCH. Neuron death including apoptosis and necroptosis might occur in the cortex of CCH. We constructed the regulatory networks of whole-transcriptomic including differentially expressed mRNAs, circRNAs, and lncRNAs, and related biological functions and pathways involved in neurological disease, cell death and survival, energy and metabolism, et al. Our results also indicated that Cyr61 mRNA may play a role in the CCH-related cortical neuronal death.ConclusionWMD and cortical neuronal death are worthy of attention in the pathogenesis of CCH. Additionally, the present results provide potential evidence at the whole-transcription level for CCH, offering candidate biomarkers and therapeutic targets.

Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion

2006 ◽  
Vol 83 (2) ◽  
pp. 285-291 ◽  
Author(s):  
Kyung-Ok Cho ◽  
Hyen O. La ◽  
Young-Jin Cho ◽  
Ki-Wug Sung ◽  
Seong Y. Kim
Keyword(s):  
White Matter ◽  
Rat Model ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
White Matter Damage

Ibudilast, a phosphodiesterase inhibitor, protects against white matter damage under chronic cerebral hypoperfusion in the rat

2003 ◽  
Vol 992 (1) ◽  
pp. 53-59 ◽  
Author(s):  
Hideaki Wakita ◽  
Hidekazu Tomimoto ◽  
Ichiro Akiguchi ◽  
Jin-Xi Lin ◽  
Masafumi Ihara ◽  
...  
Keyword(s):  
White Matter ◽  
Phosphodiesterase Inhibitor ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
White Matter Damage

scholarly journals Cilostazol Protects Against Brain White Matter Damage and Cognitive Impairment in a Rat Model of Chronic Cerebral Hypoperfusion

Stroke ◽  
2006 ◽  
Vol 37 (6) ◽  
pp. 1539-1545 ◽  
Author(s):  
Terubumi Watanabe ◽  
Ning Zhang ◽  
Meizi Liu ◽  
Ryota Tanaka ◽  
Yoshikuni Mizuno ◽  
...  
Keyword(s):  
Cognitive Impairment ◽  
White Matter ◽  
Rat Model ◽  
Chronic Cerebral Hypoperfusion ◽  
Cerebral Hypoperfusion ◽  
White Matter Damage ◽  
Brain White Matter
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