Transient cognitive deficits are associated with the reversible accumulation of amyloid precursor protein after mild traumatic brain injury

2006 ◽  
Vol 409 (3) ◽  
pp. 182-186 ◽  
Author(s):  
Shihong Li ◽  
Toshihiko Kuroiwa ◽  
Satoru Ishibashi ◽  
Liyuan Sun ◽  
Shu Endo ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Amyloid Precursor Protein ◽  
Mild Traumatic Brain Injury ◽  
Cognitive Deficits ◽  
Precursor Protein

Characterisation of the effect of knockout of the amyloid precursor protein on outcome following mild traumatic brain injury

2012 ◽  
Vol 1451 ◽  
pp. 87-99 ◽  
Author(s):  
Frances Corrigan ◽  
Robert Vink ◽  
Peter C. Blumbergs ◽  
Colin L. Masters ◽  
Roberto Cappai ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Amyloid Precursor Protein ◽  
Mild Traumatic Brain Injury ◽  
Precursor Protein

scholarly journals Metabolic and Structural Imaging at 7 Tesla After Repetitive Mild Traumatic Brain Injury in Immature Rats

ASN NEURO ◽  
2018 ◽  
Vol 10 ◽  
pp. 175909141877054 ◽  
Author(s):  
Emin Fidan ◽  
Lesley M. Foley ◽  
Lee Ann New ◽  
Henry Alexander ◽  
Patrick M. Kochanek ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Diffusion Tensor Imaging ◽  
Brain Injury ◽  
White Matter ◽  
Amyloid Precursor Protein ◽  
Mild Traumatic Brain Injury ◽  
Diffusion Tensor ◽  
Beta Amyloid ◽  
Precursor Protein ◽  
7 Tesla

Mild traumatic brain injury (mTBI) in children is a common and serious public health problem. Traditional neuroimaging findings in children who sustain mTBI are often normal, putting them at risk for repeated mTBI (rmTBI). There is a need for more sensitive imaging techniques capable of detecting subtle neurophysiological alterations after injury. We examined neurochemical and white matter changes using diffusion tensor imaging of the whole brain and proton magnetic resonance spectroscopy of the hippocampi at 7 Tesla in 18-day-old male rats at 7 days after mTBI and rmTBI. Traumatic axonal injury was assessed by beta-amyloid precursor protein accumulation using immunohistochemistry. A significant decrease in fractional anisotropy and increase in axial and radial diffusivity were observed in several brain regions, especially in white matter regions, after a single mTBI versus sham and more prominently after rmTBI. In addition, we observed accumulation of beta-amyloid precursor protein in the external capsule after mTBI and rmTBI. mTBI and rmTBI reduced the N-acetylaspartate/creatine ratio (NAA/Cr) and increased the myoinositol/creatine ratio (Ins/Cr) versus sham. rmTBI exacerbated the reduction in NAA/Cr versus mTBI. The choline/creatine (Cho/Cr) and (lipid/Macro Molecule 1)/creatine (Lip/Cr) ratios were also decreased after rmTBI versus sham. Diffusion tensor imaging findings along with the decrease in Cho and Lip after rmTBI may reflect damage to axonal membrane. NAA and Ins are altered at 7 days after mTBI and rmTBI likely reflecting neuro-axonal damage and glial response, respectively. These findings may be relevant to understanding the extent of disability following mTBI and rmTBI in the immature brain and may identify possible therapeutic targets.

scholarly journals The Adverse Pial Arteriolar and Axonal Consequences of Traumatic Brain Injury Complicated by Hypoxia and Their Therapeutic Modulation with Hypothermia in Rat

2009 ◽  
Vol 30 (3) ◽  
pp. 628-637 ◽  
Author(s):  
Guoyi Gao ◽  
Yasutaka Oda ◽  
Enoch P Wei ◽  
John T Povlishock
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Amyloid Precursor Protein ◽  
Vascular Reactivity ◽  
Axonal Damage ◽  
Precursor Protein ◽  
Moderate Hypothermia ◽  
Vascular Protection ◽  
Impact Acceleration ◽  
Cerebral Vascular

This study examined the effect of posttraumatic hypoxia on cerebral vascular responsivity and axonal damage, while also exploring hypothermia's potential to attenuate these responses. Rats were subjected to impact acceleration injury (IAI) and equipped with cranial windows to assess vascular reactivity to topical acetylcholine, with postmortem analyses using antibodies to amyloid precursor protein to assess axonal damage. Animals were subjected to hypoxia alone, IAI and hypoxia, IAI and hypoxia before induction of moderate hypothermia (33°C), IAI and hypoxia induced during hypothermic intervention, and IAI and hypoxia initiated after hypothermia. Hypoxia alone had no impact on vascular reactivity or axonal damage. Acceleration injury and posttraumatic hypoxia resulted in dramatic axonal damage and altered vascular reactivity. When IAI and hypoxia were followed by hypothermic intervention, no axonal or vascular protection ensued. However, when IAI was followed by hypoxia induced during hypothermia, axonal and vascular protection followed. When this same hypoxic insult followed the use of hypothermia, no benefit ensued. These studies show that early hypoxia and delayed hypoxia exert damaging axonal and vascular consequences. Although this damage is attenuated by hypothermia, this follows only when hypoxia occurs during hypothermia, with no benefit found if the hypoxic insult proceeds or follows hypothermia.

Correlation of ubiquitin C terminal hydrolase and S100β with cognitive deficits in young adults with mild traumatic brain injury

2017 ◽  
Vol 65 (4) ◽  
pp. 761 ◽  
Author(s):  
DhavalP Shukla ◽  
Subir Dey ◽  
Jagathlal Gangadharan ◽  
Akhil Deepika ◽  
JKeshav Kumar ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Young Adults ◽  
Brain Injury ◽  
Mild Traumatic Brain Injury ◽  
Cognitive Deficits

Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI)

2016 ◽  
Vol 101 ◽  
pp. 506-518 ◽  
Author(s):  
Anna Lesniak ◽  
Chaim G. Pick ◽  
Aleksandra Misicka ◽  
Andrzej W. Lipkowski ◽  
Mariusz Sacharczuk
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Mouse Model ◽  
Mild Traumatic Brain Injury ◽  
Cognitive Deficits

scholarly journals Subacute Changes in Cleavage Processing of Amyloid Precursor Protein and Tau following Penetrating Traumatic Brain Injury

PLoS ONE ◽  
2016 ◽  
Vol 11 (7) ◽  
pp. e0158576 ◽  
Author(s):  
Casandra M. Cartagena ◽  
Andrea Mountney ◽  
Hye Hwang ◽  
Adam Swiercz ◽  
Zoe Rammelkamp ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Penetrating Traumatic Brain Injury
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