Phenotypical analysis of adult rat olfactory ensheathing cells on 3-D collagen scaffolds

2006 ◽  
Vol 401 (1-2) ◽  
pp. 65-70 ◽  
Author(s):  
Bin Wang ◽  
Yanhong Zhao ◽  
Hang Lin ◽  
Bing Chen ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Olfactory Ensheathing Cells ◽  
Collagen Scaffolds ◽  
Adult Rat ◽  
Ensheathing Cells

scholarly journals Transplanted Olfactory Ensheathing Cells Promote Regeneration of Cut Adult Rat Optic Nerve Axons

2003 ◽  
Vol 23 (21) ◽  
pp. 7783-7788 ◽  
Author(s):  
Ying Li ◽  
Yves Sauvé ◽  
Daqing Li ◽  
Raymond D. Lund ◽  
Geoffrey Raisman
Keyword(s):  
Optic Nerve ◽  
Olfactory Ensheathing Cells ◽  
Adult Rat ◽  
Ensheathing Cells

scholarly journals Olfactory ensheathing cells from the nasal mucosa and olfactory bulb have distinct membrane properties

2019 ◽  
Author(s):  
Katie E. Smith ◽  
Katherine Whitcroft ◽  
Stuart Law ◽  
Peter Andrews ◽  
David Choi ◽  
...  
Keyword(s):  
Olfactory Bulb ◽  
Membrane Properties ◽  
Olfactory Ensheathing Cells ◽  
List Type ◽  
Molecular Physiology ◽  
Adult Rat ◽  
Axonal Regrowth ◽  
Ensheathing Cells ◽  
Inward Currents

AbstractTransplantation of Olfactory Ensheathing Cells (OECs) is a potential therapy for the regeneration of damaged neurons. While they maintain tissue homeostasis in the olfactory mucosa (OM) and olfactory bulb (OB), their regenerative properties also support the normal sense of smell by enabling continual turnover and axonal regrowth of olfactory sensory neurons (OSNs). However, the molecular physiology of OECs is not fully understood, especially that of OECs from the mucosa. Here, we carried out whole-cell patch clamp recordings from individual OECs cultured from the OM and OB of the adult rat, and from the human OM. A subset of OECs from the rat OM cultured 1-3 days in vitro (DIV) had large weakly rectifying K+ currents, which were sensitive to Ba2+ and desipramine, blockers of Kir4-family channels. Kir4.1 immunofluorescence was detectable in OM cells co-labelled for the OEC marker S100, and found adjacent to axons of OSNs. OECs cultured from rat OB had distinct properties though, displaying strongly rectifying inward currents at hyperpolarized membrane potentials and strongly rectifying outward currents at depolarized potentials. Kir4.1 immunofluorescence was not evident in OECs adjacent to axons of OSNs in the OB. A subset of human OECs cultured from the OM of adults had membrane properties comparable to those of the rat OM, i.e. dominated by Ba2+-sensitive weak inwardly rectifying currents. The membrane properties of peripheral OECs are different to those in central OECs, suggesting they may play distinct roles during olfaction.Table of Contents ImageMain pointsPeripheral and central OECs are functionally distinctPeripheral OECs have large weak inward rectifier currentsCentral OECs have strong inward and outward rectifier currents

Repair of Adult Rat Corticospinal Tract by Transplants of Olfactory Ensheathing Cells

Science ◽  
1997 ◽  
Vol 277 (5334) ◽  
pp. 2000-2002 ◽  
Author(s):  
Ying Li ◽  
Pauline M. Field ◽  
Geoffrey Raisman
Keyword(s):  
Corticospinal Tract ◽  
Olfactory Ensheathing Cells ◽  
Adult Rat ◽  
Ensheathing Cells
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