scholarly journals Small conductance Ca 2+ -activated K + channels in the plasma membrane, mitochondria and the ER: Pharmacology and implications in neuronal diseases

2017 ◽  
Vol 109 ◽  
pp. 13-23 ◽  
Author(s):  
Birgit Honrath ◽  
Inge E. Krabbendam ◽  
Carsten Culmsee ◽  
Amalia M. Dolga
Keyword(s):  
Plasma Membrane ◽  
K Channels ◽  
Small Conductance

ASSA13-06-2 Characterization of Small-Conductance Ca2+-Activated K+Channels in Patients with Chronic Atrial Fibrillation

Heart ◽  
2013 ◽  
Vol 99 (Suppl 1) ◽  
pp. A33.2-A33
Author(s):  
Li Miao-ling ◽  
Li Tao ◽  
Lan Huan ◽  
Mao Liang ◽  
Ou Xian-hong ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Chronic Atrial Fibrillation ◽  
K Channels ◽  
Small Conductance

Decreased expression of small-conductance Ca2+-activated K+ channels SK1 and SK2 in human chronic atrial fibrillation

Life Sciences ◽  
2012 ◽  
Vol 90 (5-6) ◽  
pp. 219-227 ◽  
Author(s):  
Tao Yu ◽  
Chunyu Deng ◽  
Ruobin Wu ◽  
Huiming Guo ◽  
Shaoyi Zheng ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Chronic Atrial Fibrillation ◽  
K Channels ◽  
Small Conductance

Voltage-Dependence of Extracellular Ca2+-Induced Modification in Properties of the Inward Rectifying K+ Channels in the Plasma Membrane of Mesophyll Protoplasts of Avena sativa

1996 ◽  
Vol 23 (3) ◽  
pp. 349 ◽  
Author(s):  
J Kourie
Keyword(s):  
Plasma Membrane ◽  
Time Constant ◽  
Avena Sativa ◽  
Voltage Dependence ◽  
Membrane Current ◽  
Time Dependent ◽  
Mesophyll Cells ◽  
K Channels ◽  
Current Passing ◽  
K Current

Data obtained using the whole-celi configuration of the patch-clamp technique reveal that characteristics of the inward rectifying K+ current across the plasma membrane of protoplasts isolated from mesophyll cells of leaves of oat (Avena sativa) are modified by increasing concentrations or removing the extracellular Ca2+. The whole-cell membrane current reveals two components. The first component an initial current II* which is the sum of two currents: (a) a linear ohmic leak current passing through non-gated channels, liNGC, and (b) a rectifying inward K+ current passing through inward rectifying gated K+ channels, IKi, that are instantaneously open. The second component of the membrane current at the steady state Iss is a time-dependent K+ current IKss defined as Iss-IiNGC and passes through inward rectifying gated K+ channels. The tail K+ current, IKT, is also defined as IT-IiNGC. Raising external calcium concentration, [Ca2+]o, from 0.1 mM to 10 mM blocked the inward rectifying currents IKi, IKss and IKT. The voltage-dependence of the activation time constant (τa) for time-dependent KC current IKss was not altered significantly by increasing [Ca2+]o whereas the deactivation time constant (τd) of the IKT increased from 16 ms to 30 ms at a Vm of -100 mV. Removal of [Ca2+]o increased the amplitude and altered the characteristics of the inward rectifying K+ current. Ten minutes after the removal of [Ca2+]o the increase in IKi was 3.5-fold larger than the increase in IKss. Furthermore, removing [Ca2+]o hastened the activation of IKss and the deactivation of IKT. However, the deactivation time constant (Td) remained dependent on membrane voltage (Vm). Extracellular Ca2+ may modulate the function of mesophyll cells by regulating K+ transport through the inward rectifying K+ channels and this may have significant implications for photosynthesis and cell expansion.

Melatonin Improves Memory Deficits in Rats with Cerebral Hypoperfusion, Possibly, Through Decreasing the Expression of Small-Conductance Ca2+-Activated K+ Channels

2019 ◽  
Vol 44 (8) ◽  
pp. 1851-1868 ◽  
Author(s):  
Hussain Al Dera ◽  
Mohammed Alassiri ◽  
Samy M. Eleawa ◽  
Mahmoud A. AlKhateeb ◽  
Abdelaziz M. Hussein ◽  
...  
Keyword(s):  
Memory Deficits ◽  
Cerebral Hypoperfusion ◽  
K Channels ◽  
Small Conductance

scholarly journals Benzamil inhibits neuronal and heterologously expressed small conductance Ca2+-activated K+ channels

2019 ◽  
Vol 158 ◽  
pp. 107738 ◽  
Author(s):  
Marisol Sampedro Castañeda ◽  
Raffaella Tonini ◽  
Christopher D. Richards ◽  
Martin Stocker ◽  
Paola Pedarzani
Keyword(s):  
K Channels ◽  
Small Conductance

scholarly journals Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca 2+ -Activated K + Channels in Pigs

2017 ◽  
Vol 10 (10) ◽  
Author(s):  
Jonas Goldin Diness ◽  
Lasse Skibsbye ◽  
Rafel Simó-Vicens ◽  
Joana Larupa Santos ◽  
Pia Lundegaard ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
K Channels ◽  
Small Conductance
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