Decreased levels of NMDA but not AMPA receptors in the lipid-raft fraction of 3xTg-AD model of Alzheimer's disease: Relation to Arc/Arg3.1 protein expression

2016 ◽  
Vol 100 ◽  
pp. 159-163 ◽  
Author(s):  
Jean-Pascal Morin ◽  
Sofía Díaz-Cintra ◽  
Federico Bermúdez-Rattoni ◽  
Ilse Delint-Ramírez
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Protein Expression ◽  
Lipid Raft ◽  
Ampa Receptors ◽  
Model Of Alzheimer’S Disease ◽  
Raft Fraction

scholarly journals Modulation of microglia and presynaptic protein expression after mesenchymal stem cells treatment in a rat model of Alzheimer's disease

IBRO Reports ◽  
2019 ◽  
Vol 6 ◽  
pp. S478
Author(s):  
Maria Florencia Zappa Villar ◽  
Juliette Lopez Hanotte ◽  
Joaquin Pardo ◽  
Gustavo Ramon Morel ◽  
Mariana Gabriela Garcia ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Protein Expression ◽  
Rat Model ◽  
Model Of Alzheimer’S Disease ◽  
Presynaptic Protein

The regulation of pituitary-thyroid abnormalities by peripheral administration of levothyroxine increased brain-derived neurotrophic factor and reelin protein expression in an animal model of Alzheimer’s disease

2018 ◽  
Vol 96 (3) ◽  
pp. 275-280 ◽  
Author(s):  
Sahreh Shabani ◽  
Yaghoob Farbood ◽  
Seyyed Ali Mard ◽  
Alireza Sarkaki ◽  
Akram Ahangarpour ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Animal Model ◽  
Protein Expression ◽  
Neurotrophic Factor ◽  
Subcutaneous Administration ◽  
Serum Levels ◽  
Brain Derived Neurotrophic Factor ◽  
Thyroid Stimulating Hormone ◽  
Model Of Alzheimer’S Disease

Alzheimer’s disease (AD) is associated with decreased serum levels of thyroid hormones (THs), increased levels of thyroid-stimulating hormone (TSH), and decreased protein expression of brain-derived neurotrophic factor (BDNF) and reelin in the hippocampus. In this study, we have evaluated the effect of subcutaneous administration of levothyroxine (L-T4) on levels of THs and TSH as well as protein expression of BDNF and reelin in AD rats. To make an animal model of AD, amyloid-beta peptide (Aβ) plus ibotenic acid were infused intrahippocampally, and rats were treated with L-T4 and (or) saline for 10 days. The levels of THs and TSH were measured by ELISA kits. Protein synthesis was detected by Western blotting method. Results have been shown that serum level of THs, BDNF, and reelin protein expression in the hippocampus were significantly decreased (P < 0.001) in AD animals and elevated significantly in AD rats treated with L-T4 (P < 0.01). Data showed that TSH level significantly decreased in AD rats treated with L-T4 (P < 0.05). These findings indicated that L-T4 increased BDNF and reelin protein expression by regulation of serum THs and TSH level in Aβ-induced AD rats.

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