Both acute and subchronic treatments with pindolol, a 5-HT1A and β1 and β2 adrenoceptor antagonist, elevate regional serotonin synthesis in the rat brain: An autoradiographic study

2012 ◽  
Vol 61 (8) ◽  
pp. 1417-1423 ◽  
Author(s):  
Ivan Skelin ◽  
Maraki Fikre-Merid ◽  
Mirko Diksic
Keyword(s):  
Rat Brain ◽  
Autoradiographic Study ◽  
Serotonin Synthesis ◽  
Adrenoceptor Antagonist

Effects of anpirtoline on regional serotonin synthesis in the rat brain: an autoradiographic study

2006 ◽  
Vol 33 (3) ◽  
pp. 325-332
Author(s):  
Arata Watanabe ◽  
Akio Nakai ◽  
Yoshihiro Tohyama ◽  
Khnah Q. Nguyen ◽  
Mirko Diksic
Keyword(s):  
Rat Brain ◽  
Autoradiographic Study ◽  
Serotonin Synthesis

scholarly journals Effects of serotine receptors agonists, TFMPP and CGS12066B, on regional serotonin synthesis in the rat brain: an autoradiographic study

2002 ◽  
Vol 80 (5) ◽  
pp. 788-798 ◽  
Author(s):  
Yoshihiro Tohyama ◽  
Fumitaka Yamane ◽  
Maraki Fikre Merid ◽  
Pierre Blier ◽  
Mirko Diksic
Keyword(s):  
Rat Brain ◽  
Autoradiographic Study ◽  
Serotonin Synthesis

Chronic buspirone treatment normalizes regional serotonin synthesis in the olfactory bulbectomized rat brain: An autoradiographic study

2006 ◽  
Vol 69 (2) ◽  
pp. 101-108 ◽  
Author(s):  
Arata Watanabe ◽  
Shu Hasegawa ◽  
Kyoko Nishi ◽  
Khnah Q. Nguyen ◽  
Mirko Diksic
Keyword(s):  
Rat Brain ◽  
Autoradiographic Study ◽  
Serotonin Synthesis

In vitro screen of inhibitors of rat brain serotonin synthesis

1969 ◽  
Vol 47 (5) ◽  
pp. 501-506 ◽  
Author(s):  
E. G. McGeer ◽  
D. A. V. Peters
Keyword(s):  
Rat Brain ◽  
Tryptophan Hydroxylase ◽  
Inhibitory Effect ◽  
Complexing Agents ◽  
Serotonin Synthesis ◽  
Structural Requirements ◽  
Class A ◽  
Numerous Data ◽  
Comparison Of The Results

Over 700 compounds were screened at 10−4 M concentration as inhibitors of the conversion of L-tryptophan-14C to serotonin-14C in crude rat brain homogenates. Most of the compounds had little or no inhibitory effect. Those with strong inhibitory properties were tested as inhibitors of 5-hydroxytryptophan decarboxylase and, if active on the decarboxylase, were assayed as tryptophan hydroxylase inhibitors. Except for a few oxidizing and complexing agents and for some substituted p-phenylenediamines, the compounds found to inhibit tryptophan hydroxylase by >50% belonged to the three types of inhibitors already known, i.e. catechols, phenylalanine and ring-substituted phenylalanines, and 6-substituted tryptophans. The numerous data in this screen make possible some comments as to the structural requirements for activity within each class. A comparison of the results on tryptophan hydroxylase with data on tyrosine hydroxylase inhibition in similar homogenates makes it clear that two separate, if somewhat similar, enzymes are involved.

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