SORL1 and SIRT1 mRNA expression and promoter methylation levels in aging and Alzheimer’s Disease

2012 ◽  
Vol 61 (7) ◽  
pp. 973-975 ◽  
Author(s):  
Tatiane Katsue Furuya ◽  
Patrícia Natália Oliveira da Silva ◽  
Spencer Luiz Marques Payão ◽  
Lucas Trevizani Rasmussen ◽  
Roger Willian de Labio ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mrna Expression ◽  
Promoter Methylation

CNP and DPYSL2 mRNA Expression and Promoter Methylation Levels in Brain of Alzheimer's Disease Patients

2012 ◽  
Vol 33 (2) ◽  
pp. 349-355 ◽  
Author(s):  
Patrícia Natalia Silva ◽  
Tatiane Katsue Furuya ◽  
Ianna Sampaio Braga ◽  
Lucas Trevizani Rasmussen ◽  
Roger Willian de Labio ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mrna Expression ◽  
Promoter Methylation

Analysis of HSPA8 and HSPA9 mRNA Expression and Promoter Methylation in the Brain and Blood of Alzheimer's Disease Patients

2013 ◽  
Vol 38 (1) ◽  
pp. 165-170 ◽  
Author(s):  
Patricia Natalia Silva ◽  
Tatiane Katsue Furuya ◽  
Ianna Lacerda Braga ◽  
Lucas Trevizani Rasmussen ◽  
Roger Willian Labio ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mrna Expression ◽  
Promoter Methylation ◽  
The Brain

MiR-335-5p Inhibits β-Amyloid (Aβ) Accumulation to Attenuate Cognitive Deficits Through Targeting c-jun-N-terminal Kinase 3 in Alzheimer’s Disease

2020 ◽  
Vol 17 (1) ◽  
pp. 93-101 ◽  
Author(s):  
Dan Wang ◽  
Zhifu Fei ◽  
Song Luo ◽  
Hai Wang
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Transgenic Mice ◽  
Western Blot ◽  
Mrna Expression ◽  
Cognitive Deficits ◽  
Protein Levels ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
The Relationship

Objectives: Alzheimer's disease (AD), also known as senile dementia, is a common neurodegenerative disease characterized by progressive cognitive impairment and personality changes. Numerous evidences have suggested that microRNAs (miRNAs) are involved in the pathogenesis and development of AD. However, the exact role of miR-335-5p in the progression of AD is still not clearly clarified. Methods: The protein and mRNA levels were measured by western blot and RNA extraction and quantitative real-time PCR (qRT-PCR), respectively. The relationship between miR-335-5p and c-jun-N-terminal kinase 3 (JNK3) was confirmed by dual-luciferase reporter assay. SH-SY5Y cells were transfected with APP mutant gene to establish the in vitro AD cell model. Flow cytometry and western blot were performed to evaluate cell apoptosis. The APP/PS1 transgenic mice were used as an in vivo AD model. Morris water maze test was performed to assess the effect of miR- 335-5p on the cognitive deficits in APP/PS1 transgenic mice. Results: The JNK3 mRNA expression and protein levels of JNK3 and β-Amyloid (Aβ) were significantly up-regulated, and the mRNA expression of miR-335-5p was down-regulated in the brain tissues of AD patients. The expression levels of miR-335-5p and JNK3 were significantly inversely correlated. Further, the dual Luciferase assay verified the relationship between miR-335- 5p and JNK3. Overexpression of miR-335-5p significantly decreased the protein levels of JNK3 and Aβ and inhibited apoptosis in SH-SY5Y/APPswe cells, whereas the inhibition of miR-335-5p obtained the opposite results. Moreover, the overexpression of miR-335-5p remarkably improved the cognitive abilities of APP/PS1 mice. Conclusion: The results revealed that the increased JNK3 expression, negatively regulated by miR-335-5p, may be a potential mechanism that contributes to Aβ accumulation and AD progression, indicating a novel approach for AD treatment.

scholarly journals Genome-Wide Profiling of miRNA and mRNA Expression in Alzheimer’s Disease

2017 ◽  
Vol 23 ◽  
pp. 2721-2731 ◽  
Author(s):  
Wan-Sheng Chang ◽  
Yong-Hong Wang ◽  
Xiao-Tun Zhu ◽  
Chuan-Jie Wu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mrna Expression ◽  
Genome Wide

scholarly journals Elevated DRD4 promoter methylation increases the risk of Alzheimer's disease in males

2016 ◽  
Vol 14 (3) ◽  
pp. 2732-2738 ◽  
Author(s):  
Huihui Ji ◽  
Yunliang Wang ◽  
Danjie Jiang ◽  
Guili Liu ◽  
Xuting Xu ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Promoter Methylation

scholarly journals MEF2C mRNA expression and cognitive function in Japanese patients with Alzheimer's disease

2017 ◽  
Vol 72 (3) ◽  
pp. 160-167 ◽  
Author(s):  
Tomoko Sao ◽  
Yuta Yoshino ◽  
Kiyohiro Yamazaki ◽  
Yuki Ozaki ◽  
Yoko Mori ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cognitive Function ◽  
Mrna Expression ◽  
Japanese Patients
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