Neuroprotective effects of allicin on spinal cord ischemia–reperfusion injury via improvement of mitochondrial function in rabbits

2012 ◽  
Vol 61 (5) ◽  
pp. 640-648 ◽  
Author(s):  
Jin-Wen Zhu ◽  
Tao Chen ◽  
Jianzhong Guan ◽  
Wen-Bo Liu ◽  
Jian Liu
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Mitochondrial Function ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia ◽  
Neuroprotective Effects

scholarly journals Neuroprotective effects of FK-506, l-carnitine and azathioprine on spinal cord ischemia-reperfusion injury

2004 ◽  
Vol 25 (1) ◽  
pp. 105-110 ◽  
Author(s):  
Serdar Akgun ◽  
Atike Tekeli ◽  
Ozlem Kurtkaya ◽  
Ali Civelek ◽  
Selim C Isbir ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia ◽  
Neuroprotective Effects ◽  
Fk 506

Neuroprotective Effects of Vigabatrin on Spinal Cord Ischemia-Reperfusion Injury

2018 ◽  
Vol 120 ◽  
pp. e33-e41 ◽  
Author(s):  
Emre Durdag ◽  
Zuhal Yildirim ◽  
Nese Lortlar Unlu ◽  
Aydemir Kale ◽  
Necdet Ceviker
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia ◽  
Neuroprotective Effects

Neuroprotective Effects of Rosuvastatin in Spinal Cord Ischemia-Reperfusion Injury in Rabbits

2015 ◽  
Vol 25 (2) ◽  
pp. 189-196 ◽  
Author(s):  
Gokhan Kurt ◽  
Emre C. Gokce ◽  
Berker Cemil ◽  
Zuhal Yildirim ◽  
Gulnur T. Kaplanoglu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia ◽  
Neuroprotective Effects

scholarly journals Polydatin Attenuates OGD/R-Induced Neuronal Injury and Spinal Cord Ischemia/Reperfusion Injury by Protecting Mitochondrial Function via Nrf2/ARE Signaling Pathway

2021 ◽  
Vol 2021 ◽  
pp. 1-19
Author(s):  
Jiheng Zhan ◽  
Xing Li ◽  
Dan Luo ◽  
Wanying Yan ◽  
Yonghui Hou ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Mitochondrial Dysfunction ◽  
Reperfusion Injury ◽  
Mitochondrial Function ◽  
Ischemia Reperfusion Injury ◽  
Cell Damage ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia ◽  
Neuronal Cell ◽  
Dependent Manner

Spinal cord ischemia/reperfusion injury (SCII) is a devastating complication of spinal or thoracic surgical procedures and can lead to paraplegia or quadriplegia. Neuronal cell damage involving mitochondrial dysfunction plays an important role in the pathogenesis of SCII. Despite the availability of various treatment options, there are currently no mitochondria-targeting drugs that have proven effective against SCII. Polydatin (PD), a glucoside of resveratrol, is known to preserve mitochondrial function in central nervous system (CNS) diseases. The aim of the present study was to explore the neuro- and mito-protective functions of PD and its underlying mechanisms. An in vitro model of SCII was established by exposing spinal cord motor neurons (SMNs) to oxygen–glucose-deprivation/reperfusion (OGD/R), and the cells were treated with different dosages of PD for varying durations. PD improved neuronal viability and protected against OGD/R-induced apoptosis and mitochondrial injury in a dose-dependent manner. In addition, PD restored the activity of neuronal mitochondria in terms of mitochondrial membrane potential (MMP), intracellular calcium levels, mitochondrial permeability transition pore (mPTP) opening, generation of reactive oxygen species (ROS), and adenosine triphosphate (ATP) levels. Mechanistically, PD downregulated Keap1 and upregulated Nrf2, NQO-1, and HO-1 in the OGD/R-treated SMNs. Likewise, PD treatment also reversed the neuronal and mitochondrial damage induced by SCII in a mouse model. Furthermore, the protective effects of PD were partially blocked by the Nrf2 inhibitor. Taken together, PD relieves mitochondrial dysfunction-induced neuronal cell damage by activating the Nrf2/ARE pathway and is a suitable therapeutic option for SCII.

Anti-apoptotic and neuroprotective effects of alpha-lipoic acid on spinal cord ischemia–reperfusion injury in rabbits

2010 ◽  
Vol 152 (9) ◽  
pp. 1591-1601 ◽  
Author(s):  
Hakan Emmez ◽  
Zuhal Yildirim ◽  
Aydemir Kale ◽  
Mehmet Tönge ◽  
Emre Durdağ ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Lipoic Acid ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia ◽  
Alpha Lipoic Acid ◽  
Neuroprotective Effects

Neuroprotective Effects of Tocilizumab on Experimentally-Induced Spinal Cord Ischemia-Reperfusion Injury

2019 ◽  
Vol 124 ◽  
pp. e208-e213 ◽  
Author(s):  
Yasar Karatas ◽  
Mehmet Fatih Erdi ◽  
Bülent Kaya ◽  
Fatih Keskin ◽  
Gökhan Cüce ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Spinal Cord Ischemia ◽  
Neuroprotective Effects ◽  
Experimentally Induced
Sign in / Sign up

Export Citation Format

Share Document