Molecular and kinetic characterization of histamine transport into adult rat cultured astrocytes

2012 ◽  
Vol 61 (3) ◽  
pp. 415-422 ◽  
Author(s):  
Katja Perdan-Pirkmajer ◽  
Sergej Pirkmajer ◽  
Katarina Černe ◽  
Mojca Kržan
1992 ◽  
Vol 70 (S1) ◽  
pp. S260-S262 ◽  
Author(s):  
Wolfgang Walz

The kinetic characterization of the Na/K/Cl cotransport of cultured astrocytes and evidence for its involvement in volume regulation and K+ net uptake during K+ clearance are reviewed. Emphasis is put on experimental evidence for a proposed sodium cycle in astrocytes; this cycle involves a Na+–K+ ATPase that is stimulated by both a high external K+ and intracellular Na+. Elevated external K+ also stimulates the Na/K/Cl carrier, transporting these ions inward. As a result Na+ is cycled across the membrane, carried inward by the Na/K/Cl carrier, and returned by the Na+–K+ ATPase. Both functionally coupled mechanisms lead to intracellular KCl accumulation and inward movements of water to compensate for increased osmolarity. The combined cycle is expected to play a major role in the regulation of physiological K+ levels in the brain.Key words: furosemide, ion homeostasis, Na+–K+ ATPase, swelling, volume regulation.


2018 ◽  
Vol 24 (11) ◽  
Author(s):  
Adriana M. Patarroyo-Vargas ◽  
Yaremis B. Merino-Cabrera ◽  
Jose C. Zanuncio ◽  
Francelina Rocha ◽  
Wellington G. Campos ◽  
...  

1987 ◽  
Vol 262 (8) ◽  
pp. 3754-3761
Author(s):  
A.J. Ganzhorn ◽  
D.W. Green ◽  
A.D. Hershey ◽  
R.M. Gould ◽  
B.V. Plapp

2012 ◽  
Vol 28 (1) ◽  
pp. 137-142 ◽  
Author(s):  
Sara R. Schlesinger ◽  
Britain Bruner ◽  
Patrick J. Farmer ◽  
Sung-Kun Kim

2014 ◽  
Vol 33 (6) ◽  
pp. 1211-1224
Author(s):  
Scheherezade García-Carrillo ◽  
Francisco J. Aranda ◽  
Antonio Ortiz ◽  
José A. Teruel

2021 ◽  
pp. 147621
Author(s):  
Arturo Avendaño-Estrada ◽  
Camilo Rios ◽  
Iñigo Aguirre-Aranda ◽  
Miguel Ángel Ávila-Rodríguez ◽  
Joaquín Manjarrez-Marmolejo ◽  
...  

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