Repeated treatment with the kappa opioid receptor agonist U69593 reverses enhanced K+ induced dopamine release in the nucleus accumbens, but not the expression of locomotor sensitization in amphetamine-sensitized rats

2012 ◽  
Vol 60 (4) ◽  
pp. 344-349 ◽  
Author(s):  
Angélica del Pilar Escobar ◽  
Francisca Alejandra Cornejo ◽  
María Estela Andrés ◽  
José Antonio Fuentealba
Keyword(s):  
Nucleus Accumbens ◽  
Opioid Receptor ◽  
Receptor Agonist ◽  
Dopamine Release ◽  
Kappa Opioid Receptor ◽  
Repeated Treatment ◽  
Locomotor Sensitization ◽  
Kappa Opioid ◽  
Opioid Receptor Agonist

scholarly journals Blockade of ethanol reward by the kappa opioid receptor agonist U50,488H

Alcohol ◽  
2009 ◽  
Vol 43 (5) ◽  
pp. 359-365 ◽  
Author(s):  
Marian L. Logrip ◽  
Patricia H. Janak ◽  
Dorit Ron
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
Kappa Opioid Receptor ◽  
Kappa Opioid ◽  
Opioid Receptor Agonist

scholarly journals A unique binding epitope for salvinorin A, a non-nitrogenous kappa opioid receptor agonist

FEBS Journal ◽  
2006 ◽  
Vol 273 (9) ◽  
pp. 1966-1974 ◽  
Author(s):  
Brian E. Kane ◽  
Marcelo J. Nieto ◽  
Christopher R. McCurdy ◽  
David M. Ferguson
Keyword(s):  
Opioid Receptor ◽  
Receptor Agonist ◽  
Kappa Opioid Receptor ◽  
Salvinorin A ◽  
Kappa Opioid ◽  
Opioid Receptor Agonist ◽  
Binding Epitope

scholarly journals Kappa-opioid receptor-dependent changes in dopamine and affective behavior occur differentially across the nucleus accumbens shell rostro-caudal axis

2020 ◽  
Author(s):  
Breanne E. Pirino ◽  
Mary B. Spodnick ◽  
Andrew T. Gargiulo ◽  
Genevieve R. Curtis ◽  
Jessica R. Barson ◽  
...  
Keyword(s):  
Nucleus Accumbens ◽  
Opioid Receptor ◽  
Dopamine Release ◽  
Neural Circuit ◽  
Ex Vivo ◽  
Kappa Opioid Receptor ◽  
Affective Behavior ◽  
Kappa Opioid ◽  
Affective Behaviors ◽  
The Impact

ABSTRACTNeural circuit engagement within the nucleus accumbens (NAc) shell is implicated in the regulation of both negative and positive affect. Classically, the dynorphin/kappa opioid receptor (KOR) system in the NAc was believed to promote dysphoric behavior, while dopamine was viewed as interacting with reward behavior, and KOR activation was known to inhibit dopamine release. Recently, however, both the KOR and dopamine systems have, separately, been shown to have differential effects across the rostro-caudal axis of the NAc shell on hedonic responses. Whether or not this is due to interactions between KORs and dopamine, and if it extends to other affective behaviors, remains to be determined. In this study, we examined in rats the relationship between the KOR and dopamine systems in both the rostral and caudal NAc shell using ex vivo fast scan cyclic voltammetry and the impact of KOR activation on affective behavior using approach-avoidance assays. We report here that activation of KORs in the caudal NAc shell significantly inhibits dopamine release, stimulates novelty-induced rearing behavior, increases avoidance behavior, and reduces locomotor activity. In contrast, activation of KORs in the rostral NAc shell inhibits dopamine release to a lesser extent and instead increases approach behavior. Taken together, these results indicate that there is heterogeneity across the rostro-caudal axis of the NAc shell in the effects of KOR stimulation on affective behaviors, and they suggest that this might be due to differences in KOR control over dopamine release.

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