Ghrelin agonists impact on Fos protein expression in brain areas related to food intake regulation in male C57BL/6 mice

2011 ◽  
Vol 59 (6) ◽  
pp. 889-895 ◽  
Author(s):  
Z. Pirnik ◽  
J. Bundziková ◽  
M. Holubová ◽  
M. Pýchová ◽  
J.A. Fehrentz ◽  
...  
Keyword(s):  
Food Intake ◽  
Protein Expression ◽  
Brain Areas ◽  
Fos Protein ◽  
Food Intake Regulation ◽  
Intake Regulation

scholarly journals Signals from intra-abdominal fat modulate insulin and leptin sensitivity through different mechanisms: Neuronal involvement in food-intake regulation

2006 ◽  
Vol 3 (3) ◽  
pp. 223-229 ◽  
Author(s):  
Tetsuya Yamada ◽  
Hideki Katagiri ◽  
Yasushi Ishigaki ◽  
Takehide Ogihara ◽  
Junta Imai ◽  
...  
Keyword(s):  
Food Intake ◽  
Abdominal Fat ◽  
Leptin Sensitivity ◽  
Food Intake Regulation ◽  
Intake Regulation

scholarly journals The long-chain fatty acid receptors FFA1 and FFA4 are involved in food intake regulation in fish brain

2020 ◽  
Vol 223 (17) ◽  
pp. jeb227330
Author(s):  
Cristina Velasco ◽  
Marta Conde-Sieira ◽  
Sara Comesaña ◽  
Mauro Chivite ◽  
Adrián Díaz-Rúa ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Food Intake ◽  
Mrna Abundance ◽  
Fish Brain ◽  
Protein Levels ◽  
Food Intake Regulation ◽  
Free Fatty Acid Receptors ◽  
Intake Regulation ◽  
Long Chain

ABSTRACTWe hypothesized that the free fatty acid receptors FFA1 and FFA4 might be involved in the anorectic response observed in fish after rising levels of long-chain fatty acids (LCFAs) such as oleate. In one experiment we demonstrated that intracerebroventricular (i.c.v.) treatment of rainbow trout with FFA1 and FFA4 agonists elicited an anorectic response 2, 6 and 24 h after treatment. In a second experiment, the same i.c.v. treatment resulted after 2 h in an enhancement in the mRNA abundance of anorexigenic neuropeptides pomca1 and cartpt and a decrease in the values of orexigenic peptides npy and agrp1. These changes occurred in parallel with those observed in the mRNA abundance and/or protein levels of the transcription factors Creb, Bsx and FoxO1, protein levels and phosphorylation status of Ampkα and Akt, and mRNA abundance of plcb1 and itrp3. Finally, we assessed in a third experiment the response of all these parameters after 2 h of i.c.v. treatment with oleate (the endogenous ligand of both free fatty acid receptors) alone or in the presence of FFA1 and FFA4 antagonists. Most effects of oleate disappeared in the presence of FFA1 and FFA4 antagonists. The evidence obtained supports the involvement of FFA1 and FFA4 in fatty acid sensing in fish brain, and thus involvement in food intake regulation through mechanisms not exactly comparable (differential response of neuropeptides and cellular signalling) to those known in mammals.

Role of paraventricular hypothalamic dopaminergic D1 receptors in food intake regulation of food-deprived rats

2018 ◽  
Vol 818 ◽  
pp. 43-49 ◽  
Author(s):  
Zahra. Mirmohammadsadeghi ◽  
Masoud. Shareghi Brojeni ◽  
Abbas. Haghparast ◽  
Afsaneh. Eliassi
Keyword(s):  
Food Intake ◽  
D1 Receptors ◽  
Food Intake Regulation ◽  
Intake Regulation

Food Intake Regulation: Amino Acid Toxicity and Changes in Rat Brain and Plasma Amino Acids

1973 ◽  
Vol 103 (4) ◽  
pp. 608-617 ◽  
Author(s):  
Y. Peng ◽  
J. Gubin ◽  
A. E. Harper ◽  
M. G. Vavich ◽  
A. R. Kemmerer
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Food Intake ◽  
Rat Brain ◽  
Plasma Amino Acids ◽  
Food Intake Regulation ◽  
Acid Toxicity ◽  
Intake Regulation

scholarly journals The Anorexigenic Neural Pathways of Oxytocin and Their Clinical Implication

2018 ◽  
Vol 107 (1) ◽  
pp. 91-104 ◽  
Author(s):  
Yuko Maejima ◽  
Shoko Yokota ◽  
Katsuhiko Nishimori ◽  
Kenju Shimomura
Keyword(s):  
Adipose Tissue ◽  
Food Intake ◽  
Fat Mass ◽  
Physiological Role ◽  
Leptin Resistance ◽  
Neural Pathways ◽  
Feeding Regulation ◽  
Food Intake Regulation ◽  
Intake Regulation ◽  
The Brain

Oxytocin was discovered in 1906 as a peptide that promotes delivery and milk ejection; however, its additional physiological functions were determined 100 years later. Many recent articles have reported newly discovered effects of oxytocin on social communication, bonding, reward-related behavior, adipose tissue, and muscle and food intake regulation. Because oxytocin neurons project to various regions in the brain that contribute to both feeding reward (hedonic feeding) and the regulation of energy balance (homeostatic feeding), the mechanisms of oxytocin on food intake regulation are complicated and largely unknown. Oxytocin neurons in the paraventricular nucleus (PVN) receive neural projections from the arcuate nucleus (ARC), which is an important center for feeding regulation. On the other hand, these neurons in the PVN and supraoptic nucleus project to the ARC. PVN oxytocin neurons also project to the brain stem and the reward-related limbic system. In addition to this, oxytocin induces lipolysis and decreases fat mass. However, these effects in feeding and adipose tissue are known to be dependent on body weight (BW). Oxytocin treatment is more effective in food intake regulation and fat mass decline for individuals with leptin resistance and higher BW, but is known to be less effective in individuals with normal BW. In this review, we present in detail the recent findings on the physiological role of oxytocin in feeding regulation and the anorexigenic neural pathway of oxytocin neurons, as well as the advantage of oxytocin usage for anti-obesity treatment.

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