Clock genes regulate neurogenic transcription factors, including NeuroD1, and the neuronal differentiation of adult neural stem/progenitor cells

2009 ◽  
Vol 54 (5-6) ◽  
pp. 277-285 ◽  
Author(s):  
Tomomi Kimiwada ◽  
Mikako Sakurai ◽  
Hiroki Ohashi ◽  
Shunsuke Aoki ◽  
Teiji Tominaga ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Progenitor Cells ◽  
Neuronal Differentiation ◽  
Clock Genes ◽  
Neural Stem Progenitor Cells

Clock genes regulate neurogenic transcription factors and the neuronal differentiation of adult neural stem/progenitor cells

2007 ◽  
Vol 58 ◽  
pp. S143
Author(s):  
Tomomi Kimiwada ◽  
Mikako Sakurai ◽  
Hiroki Ohashi ◽  
Shunsuke Aoki ◽  
Teiji Tominaga ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Progenitor Cells ◽  
Neuronal Differentiation ◽  
Clock Genes ◽  
Neural Stem Progenitor Cells

Mitochondrial dysfunction-induced KDM5A degradation impairs adult hippocampal neurogenesis in Alzheimer’s disease

2020 ◽  
Author(s):  
Dong Kyu Kim ◽  
Hyobin Jeong ◽  
Jingi Bae ◽  
Moon-Yong Cha ◽  
Moonkyung Kang ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Mitochondrial Dysfunction ◽  
Progenitor Cells ◽  
Neuronal Differentiation ◽  
Neural Progenitor Cells ◽  
Neural Progenitor ◽  
Hippocampal Neurogenesis ◽  
Adult Hippocampal Neurogenesis ◽  
Amyloid Pathology ◽  
Neural Stem Progenitor Cells

Abstract Background Adult hippocampal neurogenesis (AHN) is a process of continuously generating functional mature neurons from neural stem cells in the dentate gyrus. In Alzheimer’s disease (AD) brains, amyloid pathology has deleterious effects on AHN, but molecular mechanisms for dysregulated AHN are unclear. Mitochondria of neural stem/progenitor cells play crucial roles in determining cell fate. Since mitochondrial dysfunction by amyloid pathology is the typical symptom of AD pathogenesis, we aim to study whether mitochondrial dysfunction of neural stem/progenitor cells by amyloid pathology causes the impairment of AHN, and elucidate the molecular mechanism of the phenomenon. Methods To investigate the effect of mitochondrial dysfunction of neural stem/progenitor cells on neuronal differentiation, we expressed mitochondria-targeted amyloid beta (mitoAβ) in neural stem/progenitor cells in vitro and in vivo. Proteomic analysis of the hippocampal tissue implicated mitochondrial dysfunction by mitoAβ as a cause of AHN deficits. We identified epigenetic regulators of neural progenitor cells that are regulated by mitoAβ expression or drug-induced mitochondrial toxicity and proposed a link between mitochondria and AHN. Results Amyloid pathology characteristically inhibited the neuronal differentiation stage, not the proliferation of neural stem/progenitor cells during AHN in early AD model mice. Mitochondrial dysfunction in neural stem/progenitor cells by expressing mitoAβ inhibited the neuronal differentiation and AHN with cognitive impairment. Mechanistic studies revealed that lysine demethylase 5A (KDM5A) was involved in the neuronal differentiation and could be degraded by mitochondrial dysfunction in neural progenitor cells, thereby inhibiting the differentiation and cognitive functions. Conclusions These results reveal the new role of KDM5A as a mediator of retrograde signaling, reflecting mitochondrial status, and that the decrease of KDM5A in neural progenitor cells by mitochondrial dysfunction impairs the neuronal differentiation and AHN, finally leading to memory deficits. These findings and its relationship to mitochondrial dysfunction suggest that mitochondrial failure in neural progenitor cells by amyloid pathology closely associates with reduced AHN in AD.

scholarly journals Long-Term Potentiation Promotes Proliferation/Survival and Neuronal Differentiation of Neural Stem/Progenitor Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (10) ◽  
pp. e76860 ◽  
Author(s):  
Taesup Cho ◽  
Jae K. Ryu ◽  
Changiz Taghibiglou ◽  
Yuan Ge ◽  
Allen W. Chan ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Neuronal Differentiation ◽  
Long Term Potentiation ◽  
Term Potentiation ◽  
Neural Stem Progenitor Cells

scholarly journals Protein Phosphatase 4 and Smek Complex Negatively Regulate Par3 and Promote Neuronal Differentiation of Neural Stem/Progenitor Cells

Cell Reports ◽  
2013 ◽  
Vol 5 (3) ◽  
pp. 593-600 ◽  
Author(s):  
Jungmook Lyu ◽  
Hee-Ryang Kim ◽  
Vicky Yamamoto ◽  
Si Ho Choi ◽  
Zong Wei ◽  
...  
Keyword(s):  
Progenitor Cells ◽  
Neuronal Differentiation ◽  
Protein Phosphatase ◽  
Neural Stem Progenitor Cells
Sign in / Sign up

Export Citation Format

Share Document