Metabolic changes in rat prefrontal cortex and hippocampus induced by chronic morphine treatment studied ex vivo by high resolution 1H NMR spectroscopy

2007 ◽  
Vol 50 (2) ◽  
pp. 386-394 ◽  
Author(s):  
Hongchang Gao ◽  
Yun Xiang ◽  
Ninglei Sun ◽  
Hang Zhu ◽  
Yaqiang Wang ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Nmr Spectroscopy ◽  
High Resolution ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Ex Vivo ◽  
Metabolic Changes ◽  
Morphine Treatment ◽  
Chronic Morphine ◽  
Chronic Morphine Treatment

Metabolic Changes Detected by Ex Vivo High Resolution 1H NMR Spectroscopy in the Striatum of 6-OHDA-Induced Parkinson’s Rat

2012 ◽  
Vol 47 (1) ◽  
pp. 123-130 ◽  
Author(s):  
Hong-Chang Gao ◽  
Huan Zhu ◽  
Cai-Yong Song ◽  
Li Lin ◽  
Yun Xiang ◽  
...  
Keyword(s):  
Nmr Spectroscopy ◽  
High Resolution ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Ex Vivo ◽  
Metabolic Changes

A comparison of cell and tissue extraction techniques using high-resolution 1H-NMR spectroscopy

2016 ◽  
Vol 29 (4) ◽  
pp. 527-527
Author(s):  
J. E. Le Belle ◽  
N. G. Harris ◽  
S. R. Williams ◽  
K. K. Bhakoo
Keyword(s):  
Nmr Spectroscopy ◽  
High Resolution ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Extraction Techniques ◽  
Tissue Extraction

Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine.

1984 ◽  
Vol 30 (3) ◽  
pp. 426-432 ◽  
Author(s):  
J R Bales ◽  
D P Higham ◽  
I Howe ◽  
J K Nicholson ◽  
P J Sadler
Keyword(s):  
Nuclear Magnetic Resonance ◽  
Nmr Spectroscopy ◽  
Magnetic Resonance ◽  
High Resolution ◽  
1H Nmr ◽  
1H Nmr Spectroscopy ◽  
Proton Nuclear Magnetic Resonance ◽  
Resonance Spectroscopy ◽  
Simple Method ◽  
Nuclear Magnetic

Abstract Numerous low-Mr metabolites--including creatinine, citrate, hippurate, glucose, ketone bodies, and various amino acids--have been identified in 400- and 500-MHz proton nuclear magnetic resonance (1H NMR) spectra of intact human urine. The presence of many of these was related to the specific condition of the donors: humans in different physiological states (resting, fasting, or post-exercise) and pathological conditions (e.g., diabetes mellitus, cadmium-induced renal dysfunction). We have also monitored the metabolism of simple nonendogenous compounds (methanol and ethanol) and of acetaminophen. The pH-dependencies of the NMR chemical shifts of some urine components are reported. Our studies show that high-resolution 1H NMR spectroscopy provides a fast, simple method for "fingerprint" identification of urinary compounds. In some cases, analytes can be quantified by standard additions or by comparing integrated peak areas for the metabolites with those for creatinine. Determinations of creatinine by 1H NMR spectroscopy compared well with those by an independent chemical assay based on the Jaffé reaction.

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