Hyperammonemia induces transport of taurine and creatine and suppresses claudin-12 gene expression in brain capillary endothelial cells in vitro

2007 ◽  
Vol 50 (1) ◽  
pp. 95-101 ◽  
Author(s):  
Mireille Bélanger ◽  
Tomoko Asashima ◽  
Sumio Ohtsuki ◽  
Hirofumi Yamaguchi ◽  
Shingo Ito ◽  
...  
Keyword(s):  
Gene Expression ◽  
Endothelial Cells ◽  
Brain Capillary ◽  
Brain Capillary Endothelial Cells ◽  
Capillary Endothelial Cells

scholarly journals Endothelin stimulates phosphatidylinositol hydrolysis and DNA synthesis in brain capillary endothelial cells

1990 ◽  
Vol 266 (2) ◽  
pp. 415-420 ◽  
Author(s):  
P Vigne ◽  
R Marsault ◽  
J P Breittmayer ◽  
C Frelin
Keyword(s):  
Endothelial Cells ◽  
Dna Synthesis ◽  
Cardiac Cells ◽  
Brain Capillary ◽  
Aortic Endothelial Cells ◽  
Brain Capillary Endothelial Cells ◽  
Important Target ◽  
Receptor Sites ◽  
Capillary Endothelial Cells

Endothelin-1 (ET-1) is a novel vasoconstricting and cardiotonic peptide that is synthesized by the vascular endothelium. Bovine aortic endothelial cells which secrete ET in vitro lack membrane receptor sites for the peptide. Endothelial cells from rat brain microvessels that do not secrete ET in vitro express large amounts of high-affinity receptors for 125I-labelled ET-1 (Kd 0.8 nM). The ET receptor is recognized by sarafotoxin S6b and the different ET peptides with the following order of potency: ET-1 (Kd 0.5 nM) approximately equal to ET-2 (Kd 0.7 nM) greater than sarafotoxin S6b (Kd 27 nM) greater than ET-3 (Kd 450 nM). This structure-activity relationship is different from those found in vascular smooth muscle cells, renal cells and cardiac cells. ET-1 stimulates DNA synthesis in brain capillary endothelial cells. It is more potent than basic fibroblast growth factor. The action of ET on endothelial cells from microvessels involves phosphatidylinositol hydrolysis and intracellular Ca2+ mobilization. These observations suggest that brain endothelial cells might be an important target for ET.

Differential expression of selectins by mouse brain capillary endothelial cells in vitro in response to distinct inflammatory stimuli

2006 ◽  
Vol 392 (3) ◽  
pp. 216-220 ◽  
Author(s):  
Caroline Coisne ◽  
Christelle Faveeuw ◽  
Yannick Delplace ◽  
Lucie Dehouck ◽  
Florence Miller ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Differential Expression ◽  
Mouse Brain ◽  
Brain Capillary ◽  
Brain Capillary Endothelial Cells ◽  
Inflammatory Stimuli ◽  
Capillary Endothelial Cells
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