Expression and changes of endogenous insulin-like growth factor-1 in neurons and glia in the gerbil hippocampus and dentate gyrus after ischemic insult

2004 ◽  
Vol 45 (1) ◽  
pp. 149-156 ◽  
Author(s):  
I Hwang
Keyword(s):  
Growth Factor ◽  
Dentate Gyrus ◽  
Insulin Like Growth Factor ◽  
Ischemic Insult ◽  
Endogenous Insulin

scholarly journals Activin-Induced Inhibin α-Subunit Production by Rat Granulosa Cells Requires Endogenous Insulin-Like Growth Factor-I1

1998 ◽  
Vol 58 (3) ◽  
pp. 712-718 ◽  
Author(s):  
Toshihide Kubo ◽  
Shunichi Shimasaki ◽  
Holly Kim ◽  
Danmei Li ◽  
Gregory F. Erickson
Keyword(s):  
Growth Factor ◽  
Granulosa Cells ◽  
Insulin Like Growth Factor ◽  
Α Subunit ◽  
Endogenous Insulin

Cortisol increases plasma insulin-like growth factor binding protein-1 in humans

1993 ◽  
Vol 128 (2) ◽  
pp. 140-143 ◽  
Author(s):  
Cheryl A Conover ◽  
Gavin D Divertie ◽  
Phillip DK Lee
Keyword(s):  
Growth Factor ◽  
Healthy Adult ◽  
Binding Protein ◽  
Random Order ◽  
Saline Infusion ◽  
Insulin Like Growth Factor ◽  
Factor Binding ◽  
Endogenous Insulin ◽  
Integrated Response ◽  
Adult Volunteers

Insulin-like growth factor binding protein-1 (IGFBP-1) modulates the metabolic and mitogenic actions of the IGF peptides. Previous studies have established insulin as the major regulator of plasma IGFBP-1 in humans, acting to suppress hepatic IGFBP-1 synthesis. In this study, we investigated the regulation of plasma IGFBP-1 by cortisol in humans, independent of insulin. Following an overnight fast, six healthy adult volunteers received a euglycemic pancreatic clamp (somatostatin, 0.12 μg·kg−1·min−1; GH, 3 ng·kg−1·min−1; insulin, 0.05 mU·kg−1·min−1) to block endogenous insulin secretion and to control glucose and plasma hormone concentrations at desired levels. Three hours after the initiation of the pancreatic clamp, each subject received an additional 360 min infusion of either cortisol (2 μg·kg−1·min−1) or saline on separate occasions and in random order. Plasma cortisol concentrations increased from 220 to 970 nmol/1 during the cortisol infusion. Insulin concentrations were maintained at approximately 30 pmol/1 throughout saline and cortisol infusions. Plasma IGFBP-1 concentrations increased threefold in response to hypoinsulinemia, reaching plateau values of ∼ 140 μg/l with saline infusion. During cortisol infusion, IGFBP-1 levels increased to ∼300 μg/I. Over the 360 min study period, the integrated response of plasma IGFBP-1 to cortisol infusion was 314% greater than to saline infusion (p <0.01). Our data confirm that, under conditions of hypoinsulinemia, cortisol is a significant modulator of plasma IGFBP-1 in humans.

Production and autocrine/paracrine effects of endogenous insulin-like growth factor-1 in rat cardiac fibroblasts

2005 ◽  
Vol 124 (1-3) ◽  
pp. 65-72 ◽  
Author(s):  
Takeshi Horio ◽  
Toshiyuki Maki ◽  
Ichiro Kishimoto ◽  
Takeshi Tokudome ◽  
Hiroyuki Okumura ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cardiac Fibroblasts ◽  
Insulin Like Growth Factor ◽  
Paracrine Effects ◽  
Endogenous Insulin
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