scholarly journals Synchronised spiking activity underlies phase amplitude coupling in the subthalamic nucleus of Parkinson's disease patients

2019 ◽  
Vol 127 ◽  
pp. 101-113 ◽  
Author(s):  
Anders Christian Meidahl ◽  
Christian K.E. Moll ◽  
Bernadette C.M. van Wijk ◽  
Alessandro Gulberti ◽  
Gerd Tinkhauser ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Phase Amplitude ◽  
Spiking Activity

scholarly journals Synchronised spiking activity underlies phase amplitude coupling in the subthalamic nucleus of Parkinson’s disease patients

2018 ◽  
Author(s):  
Anders Christian Meidahl ◽  
Christian K.E. Moll ◽  
Bernadette van Wijk ◽  
Alessandro Gulberti ◽  
Gerd Tinkhauser ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Single Unit ◽  
Closed Loop ◽  
Beta Phase ◽  
Frequency Range ◽  
Phase Amplitude ◽  
Deep Brain ◽  
Spiking Activity

AbstractBoth phase-amplitude coupling (PAC) and beta-bursts in the subthalamic nucleus have been significantly linked to symptom severity in Parkinson’s disease (PD) in humans and emerged independently as competing biomarkers for closed-loop deep brain stimulation (DBS). However, the underlying nature of subthalamic PAC is poorly understood and its relationship with transient beta burst-events has not been investigated. To address this, we studied macro- and micro electrode recordings of local field potentials (LFPs) and single unit activity from 15 hemispheres in 10 PD patients undergoing DBS surgery. PAC between beta phase and high frequency oscillation (HFO) amplitude was compared to single unit firing rates, spike triggered averages, power spectral densities and phase-spike locking, and was studied in periods of beta-bursting. We found a significant synchronisation of spiking to HFOs and correlation of mean firing rates with HFO-amplitude when the latter was coupled to beta phase (i.e. in the presence of PAC). In the presence of PAC, single unit power spectra displayed peaks in the beta and HFO frequency range and the HFO frequency was correlated with that in the LFP. Finally, PAC significantly increased with beta burst-duration. Our findings offer new insight in the pathology of Parkinson’s disease by providing evidence that subthalamic PAC reflects the locking of spiking activity to network beta oscillations and that this coupling progressively increases with beta-burst duration. These findings suggest that beta-bursts capture periods of increased subthalamic input/output synchronisation in the beta frequency range and have important implications for therapeutic closed-loop DBS.Significance statementIdentifying biomarkers for closed-loop deep brain stimulation (DBS) has become an increasingly important issue in Parkinson’s Disease (PD) research. Two such biomarkers, phase–amplitude coupling (PAC) and beta-bursts, recorded from the implanted electrodes in subthalamic nucleus in PD patients, correlate with motor impairment. However, the physiological basis of PAC, and it relationship to beta bursts, is unclear. We provide multiple lines of evidence that PAC in the human STN reflects the locking of spiking activity to network beta oscillations and that this coupling progressively increases with the duration of beta-bursts. This suggests that beta-bursts capture increased subthalamic input/output synchronisation and provides new insights in PD pathology with direct implications for closed-loop DBS therapy strategies.

scholarly journals Subthalamic nucleus phase–amplitude coupling correlates with motor impairment in Parkinson’s disease

2016 ◽  
Vol 127 (4) ◽  
pp. 2010-2019 ◽  
Author(s):  
Bernadette C.M. van Wijk ◽  
Martijn Beudel ◽  
Ashwani Jha ◽  
Ashwini Oswal ◽  
Tom Foltynie ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Subthalamic Nucleus ◽  
Motor Impairment ◽  
Phase Amplitude
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