Transgenic mice with high endogenous omega-3 fatty acids are protected from spinal cord injury

2013 ◽  
Vol 51 ◽  
pp. 104-112 ◽  
Author(s):  
Siew-Na Lim ◽  
Stacy J. Gladman ◽  
Simon C. Dyall ◽  
Urva Patel ◽  
Nabeel Virani ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Fatty Acids ◽  
Spinal Cord Injury ◽  
Transgenic Mice ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Cord Injury

scholarly journals Neuroprotective effect of omega‐3 fatty acids on spinal cord injury induced rats

2019 ◽  
Vol 9 (8) ◽  
Author(s):  
Jiaqi Bi ◽  
Chong Chen ◽  
Peiyu Sun ◽  
Haining Tan ◽  
Fan Feng ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Fatty Acids ◽  
Spinal Cord Injury ◽  
Neuroprotective Effect ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Cord Injury

scholarly journals Regulation of Inflammasomes by Application of Omega-3 Polyunsaturated Fatty Acids in a Spinal Cord Injury Model

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3147
Author(s):  
Maryam Baazm ◽  
Victoria Behrens ◽  
Cordian Beyer ◽  
Omid Nikoubashman ◽  
Adib Zendedel
Keyword(s):  
Spinal Cord ◽  
Fatty Acids ◽  
Spinal Cord Injury ◽  
Polyunsaturated Fatty Acids ◽  
Neuronal Damage ◽  
Medium Chain Triglyceride ◽  
Therapeutic Effects ◽  
Omega 3 ◽  
Caspase 1 ◽  
Cord Injury

Omega-3 polyunsaturated fatty acids (PUFA n3) ameliorate inflammation in different diseases and potentially improve neurological function after neuronal injury. Following spinal cord injury (SCI), inflammatory events result in caspase-1 mediated activation of interleukin-1 beta (IL-1b) and 18. We aim to evaluate the neuroprotective potency of PUFA n3 in suppressing the formation and activation of inflammasomes following SCI. Male Wistar rats were divided into four groups: control, SCI, SCI+PUFA n3, and SCI+Lipofundin MCT (medium-chain triglyceride; vehicle). PUFA n3 or vehicle was intravenously administered immediately after SCI and every 24 h for the next three days. We analyzed the expression of NLRP3, NLRP1, ASC, caspase-1, IL-1b, and 18 in the spinal cord. The distribution of microglia, oligodendrocytes, and astrocytes was assessed by immunohistochemistry analysis. Behavioral testing showed significantly improved locomotor recovery in PUFA n3-treated animals and the SCI-induced upregulation of inflammasome components was reduced. Histopathological evaluation confirmed the suppression of microgliosis, increased numbers of oligodendrocytes, and the prevention of demyelination by PUFA n3. Our data support the neuroprotective role of PUFA n3 by targeting the NLRP3 inflammasome. These findings provide evidence that PUFA n3 has therapeutic effects which potentially attenuate neuronal damage in SCI and possibly also in other neuronal injuries.

scholarly journals Significance of Omega-3 Fatty Acids in the Prophylaxis and Treatment after Spinal Cord Injury in Rodent Models

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Piotr Wojdasiewicz ◽  
Łukasz A. Poniatowski ◽  
Paweł Turczyn ◽  
Justyna Frasuńska ◽  
Agnieszka Paradowska-Gorycka ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Fatty Acids ◽  
Spinal Cord Injury ◽  
Cell Membranes ◽  
Oxidative Stress Marker ◽  
Rodent Models ◽  
Omega 3 ◽  
Essential Components ◽  
Cord Injury

Polyunsaturated fatty acids (ω-3 acids, PUFAs) are essential components of cell membranes in all mammals. A multifactorial beneficial influence of ω-3 fatty acids on the health of humans and other mammals has been observed for many years. Therefore, ω-3 fatty acids and their function in the prophylaxis and treatment of various pathologies have been subjected to numerous studies. Regarding the documented therapeutic influence of ω-3 fatty acids on the nervous and immune systems, the aim of this paper is to present the current state of knowledge and the critical assessment of the role of ω-3 fatty acids in the prophylaxis and treatment of spinal cord injury (SCI) in rodent models. The prophylactic properties (pre-SCI) include the stabilization of neuron cell membranes, the reduction of the expression of inflammatory cytokines (IL-1β, TNF-α, IL-6, and KC/GRO/CINC), the improvement of local blood flow, reduced eicosanoid production, activation of protective intracellular transcription pathways (dependent on RXR, PPAR-α, Akt, and CREB), and increased concentration of lipids, glycogen, and oligosaccharides by neurons. On the other hand, the therapeutic properties (post-SCI) include the increased production of endogenous antioxidants such as carnosine and homocarnosine, the maintenance of elevated GSH concentrations at the site of injury, reduced concentrations of oxidative stress marker (MDA), autophagy improvement (via increasing the expression of LC3-II), and p38 MAPK expression reduction in the superficial dorsal horns (limiting the sensation of neuropathic pain). Paradoxically, despite the well-documented protective activity of ω-3 acids in rodents with SCI, the research does not offer an answer to the principal question of the optimal dose and treatment duration. Therefore, it is worth emphasizing the role of multicenter rodent studies with the implementation of standards which initially may even be based on arbitrary criteria. Additionally, basing on available research data, the authors of this paper make a careful attempt at referring some of the conclusions to the human population.

scholarly journals Fat-1 transgenic mice with elevated omega-3 fatty acids are protected from allergic airway responses

2011 ◽  
Vol 1812 (9) ◽  
pp. 1164-1169 ◽  
Author(s):  
Sueleyman Bilal ◽  
Oliver Haworth ◽  
Lijun Wu ◽  
Karsten H. Weylandt ◽  
Bruce D. Levy ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Transgenic Mice ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Airway Responses
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