scholarly journals Excitatory amplification through divergent–convergent circuits: The role of the midline thalamus in limbic seizures

2011 ◽  
Vol 43 (2) ◽  
pp. 435-445 ◽  
Author(s):  
David M. Sloan ◽  
DeXing Zhang ◽  
Edward H. Bertram
Keyword(s):  
Limbic Seizures ◽  
Midline Thalamus

Activation of brain metabolism and fos during limbic seizures: The role of Locus Coeruleus

2008 ◽  
Vol 30 (3) ◽  
pp. 388-399 ◽  
Author(s):  
Filippo S. Giorgi ◽  
Fabio Blandini ◽  
Emanuela Cantafora ◽  
Francesca Biagioni ◽  
Marie-Therese Armentero ◽  
...  
Keyword(s):  
Locus Coeruleus ◽  
Brain Metabolism ◽  
Limbic Seizures

scholarly journals ANALYSIS OF HIGH-RESOLUTION MICROELECTRODE EEG RECORDINGS IN AN ANIMAL MODEL OF SPONTANEOUS LIMBIC SEIZURES

2009 ◽  
Vol 19 (02) ◽  
pp. 605-617 ◽  
Author(s):  
C. KOMALAPRIYA ◽  
M. C. ROMANO ◽  
M. THIEL ◽  
U. SCHWARZ ◽  
J. KURTHS ◽  
...  
Keyword(s):  
Animal Model ◽  
High Resolution ◽  
High Frequency ◽  
Recurrence Time ◽  
Very High Frequency ◽  
Limbic Seizures ◽  
High Frequency Oscillations ◽  
Quantification Analysis ◽  
Eeg Recordings

We perform a systematic data analysis on high resolution (0.5–12 kHz) multiarray microelectrode recordings from an animal model of spontaneous limbic epilepsy, to investigate the role of high frequency oscillations and the occurrence of early precursors for seizures. Results of spectral analysis confirm the importance of very high frequency oscillations (even greater than 600 Hz) in normal (healthy) and abnormal (epileptic) hippocampus. Furthermore, we show that the measures of Recurrence Quantification Analysis (RQA) and Recurrence Time Statistics (RTS) are successful in indicating, rather uniquely, the onset of ictal state and the occurrence of some warnings/precursors during the pre-ictal state, in contrast to the linear measures investigated.

scholarly journals Early Ictal Recruitment of Midline Thalamus in Mesial Temporal Lobe Epilepsy

2019 ◽  
Author(s):  
Andrew Romeo ◽  
Alexandra T. Issa Roach ◽  
Emilia Toth ◽  
G. Chaitanya ◽  
Adeel Ilyas ◽  
...  
Keyword(s):  
Temporal Lobe Epilepsy ◽  
Evoked Potentials ◽  
Temporal Lobe ◽  
Opposite Direction ◽  
Mesial Temporal Lobe Epilepsy ◽  
Midline Thalamus ◽  
Temporal Lobe Seizures ◽  
Mesial Temporal Lobe ◽  
Stimulation Of

AbstractThe causal role of midline thalamus in the initiation and early organization of mesial temporal lobe seizures is studied. Three patients undergoing stereoelectroencephalography were enrolled for the placement of an additional depth electrode targeting the midline thalamus. The midline thalamus was recruited in all three patients at varying points of seizure initiation (0-13 seconds) and early propagation (9-60 seconds). Stimulation of either thalamus or hippocampus induced similar habitual seizures. Seizure-induced in the hippocampus rapidly recruited the thalamus. Evoked potentials demonstrated stronger connectivity from the hippocampus to the thalamus than in the opposite direction. The midline thalamus can be within the seizure initiation and symptomatogenic circuits.

Role of endorphin derivatives on EEG limbic seizures induced by CRF

1988 ◽  
Vol 20 ◽  
pp. 304
Author(s):  
S. Pieretti ◽  
E. Ortolani ◽  
A. Di Giannuario ◽  
D. Nerozzi ◽  
A. Loizzo
Keyword(s):  
Limbic Seizures

scholarly journals A ventrolateral medulla-midline thalamic circuit for hypoglycemic feeding

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
B. Sofia Beas ◽  
Xinglong Gu ◽  
Yan Leng ◽  
Omar Koita ◽  
Shakira Rodriguez-Gonzalez ◽  
...  
Keyword(s):  
Ventrolateral Medulla ◽  
Cellular Mechanisms ◽  
Posterior Portion ◽  
Functional Connections ◽  
Midline Thalamus ◽  
Anatomical Imaging ◽  
Seeking Behavior ◽  
Catecholamine Neurons ◽  
Food Seeking

AbstractMarked deficits in glucose availability, or glucoprivation, elicit organism-wide counter-regulatory responses whose purpose is to restore glucose homeostasis. However, while catecholamine neurons of the ventrolateral medulla (VLMCA) are thought to orchestrate these responses, the circuit and cellular mechanisms underlying specific counter-regulatory responses are largely unknown. Here, we combined anatomical, imaging, optogenetic and behavioral approaches to interrogate the circuit mechanisms by which VLMCA neurons orchestrate glucoprivation-induced food seeking behavior. Using these approaches, we found that VLMCA neurons form functional connections with nucleus accumbens (NAc)-projecting neurons of the posterior portion of the paraventricular nucleus of the thalamus (pPVT). Importantly, optogenetic manipulations revealed that while activation of VLMCA projections to the pPVT was sufficient to elicit robust feeding behavior in well fed mice, inhibition of VLMCA–pPVT communication significantly impaired glucoprivation-induced feeding while leaving other major counterregulatory responses intact. Collectively our findings identify the VLMCA–pPVT–NAc pathway as a previously-neglected node selectively controlling glucoprivation-induced food seeking. Moreover, by identifying the ventrolateral medulla as a direct source of metabolic information to the midline thalamus, our results support a growing body of literature on the role of the PVT in homeostatic regulation.

scholarly journals The role of connexin43 hemichannels in limbic seizures

2015 ◽  
Vol 9 ◽  
Author(s):  
Walrave Laura ◽  
Vinken Mathieu ◽  
Leybaert Luc ◽  
Smolders Ilse
Keyword(s):  
Limbic Seizures

Pharmacological evidence indicating a role of GABAergic systems in termination of limbic seizures

1990 ◽  
Vol 7 (3) ◽  
pp. 197-204 ◽  
Author(s):  
Janet L. Stringer ◽  
Eric W. Lothman
Keyword(s):  
Limbic Seizures

scholarly journals Role of the Y5 neuropeptide Y receptor in limbic seizures

1999 ◽  
Vol 96 (23) ◽  
pp. 13518-13523 ◽  
Author(s):  
D. J. Marsh ◽  
S. C. Baraban ◽  
G. Hollopeter ◽  
R. D. Palmiter
Keyword(s):  
Neuropeptide Y ◽  
Limbic Seizures ◽  
Neuropeptide Y Receptor

The role of nitric oxide in focally-evoked limbic seizures

Neuroscience ◽  
1997 ◽  
Vol 76 (4) ◽  
pp. 1231-1236 ◽  
Author(s):  
M.R Proctor ◽  
F Fornai ◽  
J.K.B Afshar ◽  
K Gale
Keyword(s):  
Nitric Oxide ◽  
Limbic Seizures
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