Short-term memory formation and long-term memory consolidation are enhanced by cellular prion association to stress-inducible protein 1

2007 ◽  
Vol 26 (1) ◽  
pp. 282-290 ◽  
Author(s):  
Adriana S. Coitinho ◽  
Marilene H. Lopes ◽  
Glaucia N.M. Hajj ◽  
Janine I. Rossato ◽  
Adriana R. Freitas ◽  
...  
Keyword(s):  
Memory Consolidation ◽  
Short Term Memory ◽  
Memory Formation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Inducible Protein

Cutting of the rat hippocampal commissure impairs short-term memory but not long-term memory

2020 ◽  
Author(s):  
Yukitoshi Sakaguchi
Keyword(s):  
Short Term Memory ◽  
Memory Formation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Dynamic Memory ◽  
Hippocampal Commissure ◽  
Functional Laterality ◽  
Left And Right

Split-brain experiments, which have been actively conducted since the twentieth century, have provided a great deal of insight into inter-hemispheric functional laterality and interactions. However, how communication between the left and right hippocampi directly contributes to memory formation is still poorly understood. To address this issue, we cut the rat hippocampal commissure (HC) connecting the left and right hippocampi prior to behavioral tests, which comprised of four memory tasks. The result showed that cutting the HC impairs short-term memory but not long-term memory. This suggests that the HC contributes mainly to the appropriate formation of short-term memory by mediating communication between the left and right hippocampi. Our findings would help to elucidate dynamic memory formation in the hippocampus and contribute to the development of therapeutics for some neurological diseases which cause a reduction in the inter-hemispheric interaction.

scholarly journals Aversive operant conditioning alters the phototactic orientation of the marbled crayfish

2021 ◽  
Vol 224 (6) ◽  
pp. jeb242180
Author(s):  
Shione Okada ◽  
Natsumi Hirano ◽  
Toshiki Abe ◽  
Toshiki Nagayama
Keyword(s):  
Operant Conditioning ◽  
Short Term Memory ◽  
Memory Formation ◽  
Long Term Memory ◽  
Aversive Learning ◽  
Short Term ◽  
Term Memory ◽  
Memory Tests ◽  
Marbled Crayfish

ABSTRACTAversive learning was applied to affect the phototactic behaviour of the marbled crayfish. Animals initially showed negative phototaxis to white light and positive taxis to blue light. Using an aversive learning paradigm, we investigated the plasticity of innate behaviour following operant conditioning. The initial rate of choosing a blue-lit exit was analysed by a dual choice experiment between blue-lit and white-lit exits in pre-test conditions. During training, electrical shocks were applied to the animals when they oriented to the blue-lit exit. Memory tests were given to analyse the orientation rate to the blue-lit exit in trials 1 and 24 h after training and these rates were compared with the pre-test. In general, animals avoided the blue-lit exit in the memory tests. When training was carried out three times, the long-term memory was retained for at least 48 h, although a single bout of training was also enough to form a long-term memory. Cooling animals at 4°C or injection of cycloheximide immediately after training altered the formation of long-term memory, but had no effect on short-term memory formation. Administration of the adenylate cyclase inhibitor SQ22536, the PKA inhibitor H89 or the CREB inhibitor KG-501 immediately after training also blocked the formation of long-term memory, but had no effect on short-term memory formation. Thus, our pharmacological behavioural analyses showed that new protein synthesis was necessary to form long-term memories and that the cAMP/PKA/CREB pathway is the main signal cascade for long-term memory formation in the marbled crayfish.

scholarly journals Disconnection between Rat’s Left and Right Hemisphere Impairs Short-Term Memory but Not Long-Term Memory

Symmetry ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 1872
Author(s):  
Yukitoshi Sakaguchi ◽  
Yoshio Sakurai
Keyword(s):  
Right Hemisphere ◽  
Short Term Memory ◽  
Memory Formation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Dynamic Memory ◽  
Left And Right ◽  
Hemispheric Interaction

Split-brain experiments, which have been actively conducted since the twentieth century, have provided a great deal of insight into functional asymmetry and inter-hemispheric interactions. However, how communication between the left and right hemispheres directly contributes to memory formation is still poorly understood. To address this issue, we cut the rat commissural fibers prior to performing behavioral tests, which consisted of two short-term and two long-term memory tasks. The result showed that cutting the commissural fibers impairs short-term memory but not long-term memory. This suggests that the left-right hemispheric interaction through the commissural fibers contributes to the appropriate formation of short-term memory, but not that of long-term memory. Our findings would help to elucidate dynamic memory formation between the two hemispheres and contribute to the development of therapeutics for some neurological diseases which cause a reduction in the inter-hemispheric interaction.

scholarly journals Modeling memory consolidation during posttraining periods in cerebellovestibular learning

2015 ◽  
Vol 112 (11) ◽  
pp. 3541-3546 ◽  
Author(s):  
Tadashi Yamazaki ◽  
Soichi Nagao ◽  
William Lennon ◽  
Shigeru Tanaka
Keyword(s):  
Memory Consolidation ◽  
Short Term Memory ◽  
Mossy Fiber ◽  
Long Term Potentiation ◽  
Memory Formation ◽  
Experimental Results ◽  
Long Term Memory ◽  
Optokinetic Response ◽  
Term Memory

Long-term depression (LTD) at parallel fiber–Purkinje cell (PF–PC) synapses is thought to underlie memory formation in cerebellar motor learning. Recent experimental results, however, suggest that multiple plasticity mechanisms in the cerebellar cortex and cerebellar/vestibular nuclei participate in memory formation. To examine this possibility, we formulated a simple model of the cerebellum with a minimal number of components based on its known anatomy and physiology, implementing both LTD and long-term potentiation (LTP) at PF–PC synapses and mossy fiber–vestibular nuclear neuron (MF–VN) synapses. With this model, we conducted a simulation study of the gain adaptation of optokinetic response (OKR) eye movement. Our model reproduced several important aspects of previously reported experimental results in wild-type and cerebellum-related gene-manipulated mice. First, each 1-h training led to the formation of short-term memory of learned OKR gain at PF–PC synapses, which diminished throughout the day. Second, daily repetition of the training gradually formed long-term memory that was maintained for days at MF–VN synapses. We reproduced such memory formation under various learning conditions. Third, long-term memory formation occurred after training but not during training, indicating that the memory consolidation occurred during posttraining periods. Fourth, spaced training outperformed massed training in long-term memory formation. Finally, we reproduced OKR gain changes consistent with the changes in the vestibuloocular reflex (VOR) previously reported in some gene-manipulated mice.

Conceptual short-term memory (CSTM) supports core claims of Christiansen and Chater

2016 ◽  
Vol 39 ◽  
Author(s):  
Mary C. Potter
Keyword(s):  
Working Memory ◽  
Rapid Serial Visual Presentation ◽  
Language Comprehension ◽  
Short Term Memory ◽  
Visual Presentation ◽  
Long Term Memory ◽  
Short Term ◽  
Term Memory ◽  
Use Of Knowledge

AbstractRapid serial visual presentation (RSVP) of words or pictured scenes provides evidence for a large-capacity conceptual short-term memory (CSTM) that momentarily provides rich associated material from long-term memory, permitting rapid chunking (Potter 1993; 2009; 2012). In perception of scenes as well as language comprehension, we make use of knowledge that briefly exceeds the supposed limits of working memory.

Comparison of Auditory, Language, Memory, and Attention Abilities in Children With and Without Listening Difficulties

2020 ◽  
Vol 29 (4) ◽  
pp. 710-727
Author(s):  
Beula M. Magimairaj ◽  
Naveen K. Nagaraj ◽  
Alexander V. Sergeev ◽  
Natalie J. Benafield
Keyword(s):  
Auditory Processing ◽  
Short Term Memory ◽  
Group Differences ◽  
Long Term Memory ◽  
Short Term ◽  
Significant Group ◽  
Term Memory ◽  
Memory And Attention ◽  
Speed And Accuracy

Objectives School-age children with and without parent-reported listening difficulties (LiD) were compared on auditory processing, language, memory, and attention abilities. The objective was to extend what is known so far in the literature about children with LiD by using multiple measures and selective novel measures across the above areas. Design Twenty-six children who were reported by their parents as having LiD and 26 age-matched typically developing children completed clinical tests of auditory processing and multiple measures of language, attention, and memory. All children had normal-range pure-tone hearing thresholds bilaterally. Group differences were examined. Results In addition to significantly poorer speech-perception-in-noise scores, children with LiD had reduced speed and accuracy of word retrieval from long-term memory, poorer short-term memory, sentence recall, and inferencing ability. Statistically significant group differences were of moderate effect size; however, standard test scores of children with LiD were not clinically poor. No statistically significant group differences were observed in attention, working memory capacity, vocabulary, and nonverbal IQ. Conclusions Mild signal-to-noise ratio loss, as reflected by the group mean of children with LiD, supported the children's functional listening problems. In addition, children's relative weakness in select areas of language performance, short-term memory, and long-term memory lexical retrieval speed and accuracy added to previous research on evidence-based areas that need to be evaluated in children with LiD who almost always have heterogenous profiles. Importantly, the functional difficulties faced by children with LiD in relation to their test results indicated, to some extent, that commonly used assessments may not be adequately capturing the children's listening challenges. Supplemental Material https://doi.org/10.23641/asha.12808607

scholarly journals An Approach toward the Development of a Functional Encoding Model of Short Term Memory during Reading

1978 ◽  
Vol 10 (2) ◽  
pp. 141-148
Author(s):  
Mary Anne Herndon
Keyword(s):  
Cluster Analysis ◽  
Storage Capacity ◽  
Short Term Memory ◽  
Long Term Memory ◽  
Short Term ◽  
Processing Efficiency ◽  
Term Memory ◽  
Information Unit ◽  
Subsequent Storage

In a model of the functioning of short term memory, the encoding of information for subsequent storage in long term memory is simulated. In the encoding process, semantically equivalent paragraphs are detected for recombination into a macro information unit. This recombination process can be used to relieve the limited storage capacity constraint of short term memory and subsequently increase processing efficiency. The results of the simulation give a favorable indication of the success for the use of cluster analysis as a tool to simulate the encoding function in the detection of semantically similar paragraphs.

scholarly journals Remember like humans

2017 ◽  
Vol 14 (1) ◽  
pp. 172988141769231 ◽  
Author(s):  
Ning An ◽  
Shi-Ying Sun ◽  
Xiao-Guang Zhao ◽  
Zeng-Guang Hou
Keyword(s):  
Short Term Memory ◽  
Three Dimensional ◽  
Sensory Memory ◽  
Long Term Memory ◽  
Observation Model ◽  
Two Dimensional ◽  
Short Term ◽  
Term Memory ◽  
Memory Register

Visual tracking is a challenging computer vision task due to the significant observation changes of the target. By contrast, the tracking task is relatively easy for humans. In this article, we propose a tracker inspired by the cognitive psychological memory mechanism, which decomposes the tracking task into sensory memory register, short-term memory tracker, and long-term memory tracker like humans. The sensory memory register captures information with three-dimensional perception; the short-term memory tracker builds the highly plastic observation model via memory rehearsal; the long-term memory tracker builds the highly stable observation model via memory encoding and retrieval. With the cooperative models, the tracker can easily handle various tracking scenarios. In addition, an appearance-shape learning method is proposed to update the two-dimensional appearance model and three-dimensional shape model appropriately. Extensive experimental results on a large-scale benchmark data set demonstrate that the proposed method outperforms the state-of-the-art two-dimensional and three-dimensional trackers in terms of efficiency, accuracy, and robustness.

Sign in / Sign up

Export Citation Format

Share Document