scholarly journals Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs

2007 ◽  
Vol 25 (2) ◽  
pp. 309-318 ◽  
Author(s):  
Jun Maruyama ◽  
Takahiko Yamagata ◽  
Mats Ulfendahl ◽  
Göran Bredberg ◽  
Richard A. Altschuler ◽  
...  
Keyword(s):  
Auditory Nerve ◽  
Guinea Pigs ◽  
Nerve Function

Degeneration of auditory nerve fibers in guinea pigs with severe sensorineural hearing loss

2017 ◽  
Vol 345 ◽  
pp. 79-87 ◽  
Author(s):  
Steven Kroon ◽  
Dyan Ramekers ◽  
Emma M. Smeets ◽  
Ferry G.J. Hendriksen ◽  
Sjaak F.L. Klis ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Sensorineural Hearing Loss ◽  
Auditory Nerve ◽  
Guinea Pigs ◽  
Nerve Fibers ◽  
Sensorineural Hearing ◽  
Auditory Nerve Fibers

Neural Presbyacusis in Humans Inferred from Age-Related Differences in Auditory Nerve Function and Structure

2021 ◽  
pp. JN-RM-1747-21
Author(s):  
Kelly C. Harris ◽  
Jayne B. Ahlstrom ◽  
James W. Dias ◽  
Lilyana B. Kerouac ◽  
Carolyn M. McClaskey ◽  
...  
Keyword(s):  
Auditory Nerve ◽  
Nerve Function ◽  
Age Related

scholarly journals Synaptic migration and reorganization after noise exposure suggests regeneration in a mature mammalian cochlea

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Tyler T. Hickman ◽  
Ken Hashimoto ◽  
Leslie D. Liberman ◽  
M. Charles Liberman
Keyword(s):  
Hair Cell ◽  
Hair Cells ◽  
Auditory Nerve ◽  
Guinea Pigs ◽  
Noise Exposure ◽  
Recovery Period ◽  
Nerve Fibers ◽  
Neural Regeneration ◽  
Adult Mice ◽  
Synaptic Markers

AbstractOverexposure to intense noise can destroy the synapses between auditory nerve fibers and their hair cell targets without destroying the hair cells themselves. In adult mice, this synaptopathy is immediate and largely irreversible, whereas, in guinea pigs, counts of immunostained synaptic puncta can recover with increasing post-exposure survival. Here, we asked whether this recovery simply reflects changes in synaptic immunostaining, or whether there is actual retraction and extension of neurites and/or synaptogenesis. Analysis of the numbers, sizes and spatial distribution of pre- and post-synaptic markers on cochlear inner hair cells, in guinea pigs surviving from 1 day to 6 months after a synaptopathic exposure, shows dramatic synaptic re-organization during the recovery period in which synapse counts recover from 16 to 91% of normal in the most affected regions. Synaptic puncta move all over the hair cell membrane during recovery, translocating far from their normal positions at the basolateral pole, and auditory-nerve terminals extend towards the hair cell’s apical end to re-establish contact with them. These observations provide stronger evidence for spontaneous neural regeneration in a mature mammalian cochlea than can be inferred from synaptic counts alone.

Adverse effects of topical papaverine on auditory nerve function

2008 ◽  
Vol 150 (9) ◽  
pp. 901-909 ◽  
Author(s):  
Geraldine M. Chadwick ◽  
Anthony L. Asher ◽  
Craig A. Van Der Veer ◽  
Richard J. Pollard
Keyword(s):  
Adverse Effects ◽  
Auditory Nerve ◽  
Nerve Function

Auditory nerve function following cochleitis

2012 ◽  
Vol 76 (11) ◽  
pp. 1696-1701 ◽  
Author(s):  
Jessica Levi ◽  
Liesl Looney ◽  
Ryan Murray ◽  
Yell Inverso ◽  
Robert C. O’Reilly ◽  
...  
Keyword(s):  
Auditory Nerve ◽  
Nerve Function

scholarly journals Near-Infrared Laser Stimulation of the Auditory Nerve in Guinea Pigs

2016 ◽  
Vol 20 (2) ◽  
pp. 269-275 ◽  
Author(s):  
Tian Guan ◽  
Jian Wang ◽  
Muqun Yang ◽  
Kai Zhu ◽  
Yong Wang ◽  
...  
Keyword(s):  
Auditory Nerve ◽  
Guinea Pigs ◽  
Near Infrared ◽  
Infrared Laser ◽  
Laser Stimulation ◽  
Stimulation Of

Auditory-Nerve Responses in Mice with Noise-Induced Cochlear Synaptopathy

2021 ◽  
Author(s):  
Kirupa Suthakar ◽  
M. Charles Liberman
Keyword(s):  
Auditory Nerve ◽  
Guinea Pigs ◽  
Frequency Tuning ◽  
Tone Burst ◽  
Nerve Fibers ◽  
Ribbon Synapses ◽  
Age Related ◽  
Synaptic Markers ◽  
Basal Half ◽  
Masking Noise

Cochlear synaptopathy is the noise-induced or age-related loss of ribbon synapses between inner hair cells (IHCs) and auditory nerve fibers (ANFs), first reported in CBA/CaJ mice. Recordings from single ANFs in anaesthesized, noise-exposed guinea pigs suggested that neurons with low spontaneous rates (SRs) and high thresholds are more vulnerable than low-threshold, high-SR fibers. However, there is extensive post-exposure regeneration of ANFs in guinea pigs, but not in mice. Here, we exposed CBA/CaJ mice to octave-band noise and recorded sound-evoked and spontaneous activity from single ANFs at least 2 weeks later. Confocal analysis of cochleae immunostained for pre- and post-synaptic markers confirmed the expected loss of 40 - 50% of ANF synapses in the basal half of the cochlea, however, our data were not consistent with a selective loss of low-SR fibers. Rather they suggested a loss of both SR groups in synaptopathic regions. Single-fiber thresholds and frequency tuning recovered to pre-exposure levels however, response to tone bursts showed increased peak and steady-state firing rates as well as decreased jitter in first-spike latencies. This apparent gain-of-function increased the robustness of tone-burst responses in the presence of continuous masking noise. This study suggests that the nature of noise-induced synaptic damage varies between different species and that, in mouse, the noise-induced hyperexcitability seen in central auditory circuits is also observed at the level of the auditory nerve.

Auditory-nerve fiber responses to clicks in guinea pigs with a damaged cochlea

1997 ◽  
Vol 101 (2) ◽  
pp. 993-1009 ◽  
Author(s):  
Huib Versnel ◽  
Vera F. Prijs ◽  
Ruurd Schoonhoven
Keyword(s):  
Nerve Fiber ◽  
Auditory Nerve ◽  
Guinea Pigs ◽  
Auditory Nerve Fiber

Surgery for sporadic vestibular schwannoma. Part III: Facial and auditory nerve function

2015 ◽  
Vol 49 (6) ◽  
pp. 373-380 ◽  
Author(s):  
Przemysław Kunert ◽  
Tomasz Dziedzic ◽  
Anna Podgórska ◽  
Tomasz Czernicki ◽  
Arkadiusz Nowak ◽  
...  
Keyword(s):  
Vestibular Schwannoma ◽  
Auditory Nerve ◽  
Nerve Function
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