Deposition of amyloid fibrils promotes cell-surface accumulation of amyloid β precursor protein

2004 ◽  
Vol 16 (3) ◽  
pp. 617-629 ◽  
Author(s):  
Lorena Heredia ◽  
Rong Lin ◽  
Francisco Solá Vigo ◽  
Gabriela Kedikian ◽  
Jorge Busciglio ◽  
...  
Keyword(s):  
Cell Surface ◽  
Amyloid Fibrils ◽  
Amyloid Β ◽  
Precursor Protein

scholarly journals The cerebrospinal-fluid soluble form of Alzheimer's amyloid β is complexed to SP-40,40 (apolipoprotein J), an inhibitor of the complement membrane-attack complex

1993 ◽  
Vol 293 (1) ◽  
pp. 27-30 ◽  
Author(s):  
J Ghiso ◽  
E Matsubara ◽  
A Koudinov ◽  
N H Choi-Miura ◽  
M Tomita ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Amyloid Fibrils ◽  
Membrane Attack Complex ◽  
Amyloid Β ◽  
Proteolytic Processing ◽  
Precursor Protein ◽  
Neuritic Plaque ◽  
Soluble Form ◽  
Direct Binding

The amyloid fibrils deposited in Alzheimer's neuritic plaque cores and cerebral blood vessels are mainly composed of aggregated forms of a unique peptide, 39-42 amino acids long, named amyloid beta (A beta). A similar, although soluble, A beta (‘sA beta’) has been identified in cerebrospinal fluid, plasma and cell supernatants, indicating that it is normally produced by proteolytic processing of its precursor protein, amyloid precursor protein (APP). Using direct binding experiments we have isolated and characterized an 80 kDa circulating protein that specifically interacts with a synthetic peptide identical with A beta. The protein was unmistakably identified as SP-40,40 or ApoJ, a cytolytic inhibitor and lipid carrier, by means of amino acid sequence and immunoreactivity with specific antibodies. Immunoprecipitation with anti-SP-40,40 retrieved soluble A beta from cerebrospinal fluid, indicating that the interaction occurs in vivo.

scholarly journals BECN1/Beclin 1 sorts cell-surface APP/amyloid β precursor protein for lysosomal degradation

Autophagy ◽  
2016 ◽  
Vol 12 (12) ◽  
pp. 2404-2419 ◽  
Author(s):  
Gayathri Swaminathan ◽  
Wan Zhu ◽  
Edward D. Plowey
Keyword(s):  
Cell Surface ◽  
Amyloid Β ◽  
Precursor Protein ◽  
Beclin 1 ◽  
Lysosomal Degradation

scholarly journals Effects of Huanglian-Jie-Du-Tang and Its Modified Formula on the Modulation of Amyloid-β Precursor Protein Processing in Alzheimer's Disease Models

PLoS ONE ◽  
2014 ◽  
Vol 9 (3) ◽  
pp. e92954 ◽  
Author(s):  
Siva Sundara Kumar Durairajan ◽  
Ying-Yu Huang ◽  
Pui-Yee Yuen ◽  
Lei-Lei Chen ◽  
Ka-Yan Kwok ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Β ◽  
Protein Processing ◽  
Precursor Protein ◽  
Disease Models ◽  
Modified Formula
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