Acetylcholinesterase induces the expression of the β-amyloid precursor protein in glia and activates glial cells in culture

2003 ◽  
Vol 14 (3) ◽  
pp. 447-457 ◽  
Author(s):  
Rommy von Bernhardi ◽  
Gigliola Ramírez ◽  
Giancarlo V De Ferrari ◽  
Nibaldo C Inestrosa
Keyword(s):  
Amyloid Precursor Protein ◽  
Glial Cells ◽  
Precursor Protein ◽  
Cells In Culture ◽  
Β Amyloid

Alzheimer’s Disease β-Amyloid Precursor Protein in Rat Neural Cells in Culture

Gerontology ◽  
1992 ◽  
Vol 38 (1) ◽  
pp. 15-23 ◽  
Author(s):  
Masashi Mizuguchi ◽  
Kazuhiko Ikeda ◽  
Yoshio Namba ◽  
Seung U. Kim
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Neural Cells ◽  
Cells In Culture ◽  
Β Amyloid

scholarly journals Glial Expression of the β-Amyloid Precursor Protein (APP) in Global Ischemia

1995 ◽  
Vol 15 (4) ◽  
pp. 647-654 ◽  
Author(s):  
R. B. Banati ◽  
J. Gehrmann ◽  
C. Wießner ◽  
K.-A. Hossmann ◽  
G. W. Kreutzberg
Keyword(s):  
Amyloid Precursor Protein ◽  
Glial Cells ◽  
Global Ischemia ◽  
Precursor Protein ◽  
Double Immunofluorescence ◽  
Neuronal Necrosis ◽  
Activated Microglia ◽  
Β Amyloid ◽  
Immunofluorescence Labeling ◽  
The Brain

The β-amyloid precursor protein (APP) bears characteristics of an acute-phase protein and therefore is likely to be involved in the glial response to brain injury. In the brain, APP is rapidly synthesized by activated glial cells in response to comparatively mild neuronal lesions, e.g., a remote peripheral nerve injury. Perfusion deficits in the brain result largely in neuronal necrosis and are a common condition in elderly patients. This neuronal necrosis is accompanied by a pronounced reaction of astrocytes and microglia, which can also be observed in animal models. We have therefore studied in the rat, immunocytochemically, the induction of APP after 30 min of global ischemia caused by four-vessel occlusion. The postishemic brain injuries were examined at survival times from 12 h to 7 days. From day 3 onward, APP immunoreactivity was strongly induced in the CA1 and CA4 regions of the rat dorsal hippocampus as well as in the dorsolateral striatum. In these areas, the majority of APP-immunoreactive cells were reactive glial fibrillary acidic protein (GFAP)-positive astrocytes, as shown by double-immunofluorescence labeling for GFAP and APP. Additionally, small ramified cells, most likely activated microglia, expressed APP immunoreactivity. In contrast, in the parietal cortex, APP immunoreactivity occurred focally in clusters of activated microglia rather than in astrocytes, as demonstrated by double-immunofluorescence labeling for APP and the microglia-binding lectin Griffonia simplicifolia isolectin B4. In conclusion, following global ischemia, APP is induced in reactive glial cells with spatial differences in the distribution pattern of APP induction in astrocytes and microglia.

scholarly journals β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

Cell ◽  
1995 ◽  
Vol 81 (4) ◽  
pp. 525-531 ◽  
Author(s):  
Hui Zheng ◽  
Minghao Jiang ◽  
Myrna E. Trumbauer ◽  
Dalip J.S. Sirinathsinghji ◽  
Ruth Hopkins ◽  
...  
Keyword(s):  
Locomotor Activity ◽  
Amyloid Precursor Protein ◽  
Precursor Protein ◽  
Reactive Gliosis ◽  
Β Amyloid ◽  
Deficient Mice
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