Monomeric α-synuclein induces blood–brain barrier dysfunction through activated brain pericytes releasing inflammatory mediators in vitro

2019 ◽  
Vol 124 ◽  
pp. 61-66 ◽  
Author(s):  
Shinya Dohgu ◽  
Fuyuko Takata ◽  
Junichi Matsumoto ◽  
Ikuya Kimura ◽  
Atsushi Yamauchi ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Inflammatory Mediators ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Blood Brain ◽  
Brain Pericytes

Role of thrombin-PAR1-PKCθ/δ axis in brain pericytes in thrombin-induced MMP-9 production and blood–brain barrier dysfunction in vitro

Neuroscience ◽  
2017 ◽  
Vol 350 ◽  
pp. 146-157 ◽  
Author(s):  
Takashi Machida ◽  
Shinya Dohgu ◽  
Fuyuko Takata ◽  
Junichi Matsumoto ◽  
Ikuya Kimura ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Blood Brain ◽  
Brain Pericytes

scholarly journals Contribution of thrombin-reactive brain pericytes to blood-brain barrier dysfunction in an in vivo mouse model of obesity-associated diabetes and an in vitro rat model

PLoS ONE ◽  
2017 ◽  
Vol 12 (5) ◽  
pp. e0177447 ◽  
Author(s):  
Takashi Machida ◽  
Fuyuko Takata ◽  
Junichi Matsumoto ◽  
Tomoyuki Miyamura ◽  
Ryosuke Hirata ◽  
...  
Keyword(s):  
Mouse Model ◽  
Blood Brain Barrier ◽  
Rat Model ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Blood Brain ◽  
Brain Pericytes

scholarly journals In vitro analysis of drugs that improve hyperglycemia-induced blood-brain barrier dysfunction

2018 ◽  
Vol 503 (3) ◽  
pp. 1885-1890 ◽  
Author(s):  
Ryoma Kayano ◽  
Yoichi Morofuji ◽  
Shinsuke Nakagawa ◽  
Shuji Fukuda ◽  
Daisuke Watanabe ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Blood Brain ◽  
Vitro Analysis ◽  
In Vitro Analysis

scholarly journals Blood–Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease

2019 ◽  
Vol 6 (20) ◽  
pp. 1900962 ◽  
Author(s):  
Yoojin Shin ◽  
Se Hoon Choi ◽  
Eunhee Kim ◽  
Enjana Bylykbashi ◽  
Jeong Ah Kim ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Blood Brain Barrier ◽  
In Vitro Model ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Blood Brain ◽  
Model Of Alzheimer’S Disease ◽  
3D In Vitro Model ◽  
Vitro Model

Blood-Brain Barrier Dysfunction after Primary Blast Injury in vitro

2013 ◽  
Vol 30 (19) ◽  
pp. 1652-1663 ◽  
Author(s):  
Christopher D. Hue ◽  
Siqi Cao ◽  
Syed F. Haider ◽  
Kiet V. Vo ◽  
Gwen B. Effgen ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Blast Injury ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Primary Blast ◽  
Blood Brain

Oncostatin-M-Reactive Pericytes Aggravate Blood–Brain Barrier Dysfunction by Activating JAK/STAT3 Signaling In Vitro

Neuroscience ◽  
2019 ◽  
Vol 422 ◽  
pp. 12-20
Author(s):  
Fuyuko Takata ◽  
Shinya Dohgu ◽  
Shinya Sakaguchi ◽  
Kenta Sakai ◽  
Gaku Yamanaka ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Oncostatin M ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Stat3 Signaling ◽  
Blood Brain

scholarly journals Myeloperoxidase-Derived Oxidants Induce Blood-Brain Barrier Dysfunction In Vitro and In Vivo

PLoS ONE ◽  
2013 ◽  
Vol 8 (5) ◽  
pp. e64034 ◽  
Author(s):  
Andreas Üllen ◽  
Evelin Singewald ◽  
Viktoria Konya ◽  
Günter Fauler ◽  
Helga Reicher ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Blood Brain

scholarly journals Pitavastatin Ameliorates Lipopolysaccharide-Induced Blood-Brain Barrier Dysfunction

Biomedicines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 837
Author(s):  
Takashi Fujimoto ◽  
Yoichi Morofuji ◽  
Andrej Kovac ◽  
Michelle A. Erickson ◽  
Mária A. Deli ◽  
...  
Keyword(s):  
Blood Brain Barrier ◽  
Neurological Diseases ◽  
Brain Barrier ◽  
Barrier Dysfunction ◽  
Neuroprotective Effects ◽  
Blood Brain ◽  
Mouse Brain Endothelial Cells ◽  
Pharmacological Significance ◽  
Primary Mouse

Statins have neuroprotective effects on neurological diseases, including a pleiotropic effect possibly related to blood–brain barrier (BBB) function. In this study, we investigated the effects of pitavastatin (PTV) on lipopolysaccharide (LPS)-induced BBB dysfunction in an in vitro BBB model comprising cocultured primary mouse brain endothelial cells, pericytes, and astrocytes. LPS (1 ng/mL, 24 h) increased the permeability and lowered the transendothelial electrical resistance of the BBB, and the co-administration of PTV prevented these effects. LPS increased the release of interleukin-6, granulocyte colony-stimulating factor, keratinocyte-derived chemokine, monocyte chemotactic protein-1, and regulated on activation, normal T-cell expressed and secreted from the BBB model. PTV inhibited the LPS-induced release of these cytokines. These results suggest that PTV can ameliorate LPS-induced BBB dysfunction, and these effects might be mediated through the inhibition of LPS-induced cytokine production. Clinically, therapeutic approaches using statins combined with novel strategies need to be designed. Our present finding sheds light on the pharmacological significance of statins in the treatment of central nervous system diseases.

Sign in / Sign up

Export Citation Format

Share Document