scholarly journals Calcium phosphate enriched synthetic tyrosine-derived polycarbonate – dicalcium phosphate dihydrate polymer scaffolds for enhanced bone regeneration

Materialia ◽  
2020 ◽  
Vol 9 ◽  
pp. 100616
Author(s):  
Shruti Saxena ◽  
Wei Chang ◽  
Amir Fakhrzadeh ◽  
N. Sanjeeva Murthy ◽  
Weibo Zhang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Regeneration ◽  
Dicalcium Phosphate ◽  
Polymer Scaffolds ◽  
Dicalcium Phosphate Dihydrate ◽  
Phosphate Dihydrate

Preparation of Calcium Phosphate Cement Utilizing Dicalcium Phosphate Dihydrate and Calcium Carbonate

2014 ◽  
Vol 608 ◽  
pp. 280-286
Author(s):  
Nudthakarn Kosachan ◽  
Angkhana Jaroenworaluck ◽  
Sirithan Jiemsirilers ◽  
Supatra Jinawath ◽  
Ron Stevens
Keyword(s):  
Calcium Carbonate ◽  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Raw Materials ◽  
Setting Time ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Cement Pastes ◽  
Setting Times ◽  
Phosphate Dihydrate

Calcium phosphate cement has been widely used as a bone substitute because of its chemical similarity to natural bone. In this study, calcium phosphate cement was prepared using dicalcium phosphate dihydrate (CaHPO4.2H2O) and calcium carbonate (CaCO3) as starting raw materials. The cement pastes were mixed and the chemistry adjusted with two different aqueous solutions of sodium hydroxide (NaOH) and disodium hydrogen phosphate (Na2HPO4). Concentrations of the solution were varied in the range 0.5 to 5.0 mol/L with the ratio of solid/liquid = 2 g/ml. The cement paste was then poured into a silicone mold having a diameter of 10 mm and a height 15 mm. Setting times for the cement were measured using a Vicat apparatus. XRD, FT-IR, and SEM techniques were used to characterize properties and microstructure of the cement. From the experimental results, it is clear that different concentrations of Na2HPO4 and NaOH have affected the setting times of the cement. The relationship between concentration of NaOH and Na2HPO4 and setting time, including final properties of the cement, is discussed.

scholarly journals Highly porous polycaprolactone scaffolds doped with calcium silicate and dicalcium phosphate dihydrate designed for bone regeneration

2019 ◽  
Vol 102 ◽  
pp. 341-361 ◽  
Author(s):  
Maria Giovanna Gandolfi ◽  
Fausto Zamparini ◽  
Micaela Degli Esposti ◽  
Federica Chiellini ◽  
Fabio Fava ◽  
...  
Keyword(s):  
Bone Regeneration ◽  
Calcium Silicate ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Phosphate Dihydrate ◽  
Highly Porous

scholarly journals Controlled synthesis of dicalcium phosphate dihydrate (DCPD) from metastable solutions: insights into pathogenic calcification

2021 ◽  
Vol 32 (12) ◽  
Author(s):  
A. D. Rafeek ◽  
G. Choi ◽  
L. A. Evans
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Calcium Phosphate ◽  
Electrostatic Interactions ◽  
The Body ◽  
Dicalcium Phosphate ◽  
Urinary Stones ◽  
Dicalcium Phosphate Dihydrate ◽  
Seeded Growth ◽  
Phosphate Dihydrate

AbstractCalcium phosphate (CaP) compounds may occur in the body as abnormal pathogenic phases in addition to their normal occurrence as bones and teeth. Dicalcium phosphate dihydrate (DCPD; CaPO4·2H2O), along with other significant CaP phases, have been observed in pathogenic calcifications such as dental calculi, kidney stones and urinary stones. While other studies have shown that polar amino acids can inhibit the growth of CaPs, these studies have mainly focused on hydroxyapatite (HAp; Ca10(PO4)6(OH)2) formation from highly supersaturated solutions, while their effects on DCPD nucleation and growth from metastable solutions have been less thoroughly explored. By further elucidating the mechanisms of DCPD formation and the influence of amino acids on those mechanisms, insights may be gained into ways that amino acids could be used in treatment and prevention of unwanted calcifications. The current study involved seeded growth of DCPD from metastable solutions at constant pH in the presence of neutral, acidic and phosphorylated amino acid side chains. As a comparison, solutions were also seeded with calcium pyrophosphate (CPP; Ca2P2O7), a known calcium phosphate inhibitor. The results show that polar amino acids inhibit DCPD growth; this likely occurs due to electrostatic interactions between amino acid side groups and charged DCPD surfaces. Phosphoserine had the greatest inhibitory ability of the amino acids tested, with an effect equal to that of CPP. Clustering of DCPD crystals giving rise to a “chrysanthemum-like” morphology was noted with glutamic acid. This study concludes that molecules containing an increased number of polar side groups will enhance the inhibition of DCPD seeded growth from metastable solutions.

Effect of Different Granular Size on the Properties of Porous β-Tricalcium Phosphate Foam Granular Cements

2019 ◽  
Vol 829 ◽  
pp. 23-27 ◽  
Author(s):  
Haifaa' Auni Mohammad Zaki ◽  
Khairul Anuar Shariff ◽  
Mohamad Hafizi Abu Bakar ◽  
Mohamad Nurul Azmi
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Reaction Times ◽  
Range Size ◽  
Dicalcium Phosphate ◽  
Morphological Observation ◽  
Phosphate Solution ◽  
Dicalcium Phosphate Dihydrate ◽  
Setting Reaction ◽  
Phosphate Dihydrate

Porous β-tricalcium phosphate (β-TCP) foam granular cements was obtained by exposing different range size of β-TCP foam granular (300-600 μm and 600-1000 μm) with 1.4 mol/L of saturated acidic calcium phosphate solution at various setting reaction times. It was found that large amount of dicalcium phosphate dihydrate (DCPD) was formed in the set specimens after exposing small size of β-TCP foam granular with saturated acidic calcium phosphate solution. Morphological observation shows that the bridging of DCPD platelet-like crystals between β-TCP foam granular surfaces were detected as early as 10 mins after exposing 300-600 μm of β-TCP foam granules with saturated acidic calcium phosphate solution. In fact, the amount of DCPD formed in the specimens obtained from small size of β-TCP foam granules is higher than large sized foam granules. These results demonstrated that small size of β-TCP foam granules induced fast setting reaction of β-TCP foam granules to produce porous β-TCP foam granular cements.

Seeded Growth of Calcium Phosphates: Effect of Different Calcium Phosphate Seed Material

1976 ◽  
Vol 55 (4) ◽  
pp. 617-624 ◽  
Author(s):  
G.H. Nancollas ◽  
J.S. Wefel
Keyword(s):  
Calcium Phosphate ◽  
Tricalcium Phosphate ◽  
Calcium Phosphates ◽  
Octacalcium Phosphate ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Seeded Growth ◽  
Seed Crystals ◽  
Phosphate Dihydrate ◽  
Supersaturated Solutions

The growth of calcium phosphates on seed materials, dicalcium PhosPhate dihydrate (DCPD), tricalcium phosphate (TCP), octacalcium phosphate (OCP), and hydroxyapatite (HAP) in stable supersaturated solutions has been studied under conditions of pH and concentration for which the predominant phases are 1, DCPD, and II, HAP. All seed crystals are good nucleators for DCPD in system I, but, aside from HAP itself, only OCP will readily induce growth under condition II.

scholarly journals REACTION PRODUCTS OF ORTHOPHOSPHATES IN SOILS CONTAINING VARYING AMOUNTS OF CALCIUM AND MAGNESIUM

1967 ◽  
Vol 47 (3) ◽  
pp. 223-230 ◽  
Author(s):  
G. J. Racz ◽  
R. J. Soper
Keyword(s):  
Calcium Phosphate ◽  
Octacalcium Phosphate ◽  
Water Soluble ◽  
Dicalcium Phosphate ◽  
Dicalcium Phosphate Dihydrate ◽  
Reaction Products ◽  
Phosphate Dihydrate ◽  
Soluble Calcium ◽  
Calcium And Magnesium ◽  
Saturated Solutions

The reaction products formed when orthophosphates (pellets) were added to 22 soils, with different calcium and magnesium contents, were identified. Di-calcium phosphate dihydrate (CaHPO4∙2H2O) formed in the soils having a water-soluble calcium to magnesium ratio of approximately 1.5 or greater. Dicalcium phosphate dihydrate and/or dimagnesium phosphate trihydrate (MgHPO4∙3H2O) formed in soils having a water-soluble calcium to magnesium ratio of less than 1.5.Dicalcium phosphate dihydrate and dimagnesium phosphate trihydrate precipitated in filtrates of two dolomitic soils shaken for 15 min with saturated solutions of KH2PO4 and NH4H2PO4. Octacalcium phosphate (Ca4H (PO4)3∙3H2O) and trimagnesium phosphate tetrahydrate (Mg3 (PO4)2∙4H2O) precipitated in filtrates of these soils when saturated solutions of K2HPO4 and (NH4)2HPO4 were used.Trimagnesium phosphate twenty-two hydrate (Mg3 ((PO4)2∙22H2O) formed when dimagnesium phosphate trihydrate was added to a soil containing large amounts of magnesium.

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