Magnetic bio-metal–organic framework nanocomposites decorated with folic acid conjugated chitosan as a promising biocompatible targeted theranostic system for cancer treatment

2019 ◽  
Vol 99 ◽  
pp. 805-815 ◽  
Author(s):  
Vajihe Nejadshafiee ◽  
Hossein Naeimi ◽  
Bahram Goliaei ◽  
Bahareh Bigdeli ◽  
Armin Sadighi ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Treatment ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Folic acid-modified metal-organic framework carries CPT and DOX for cancer treatment

2021 ◽  
pp. 122803
Author(s):  
Bao-Xuan Xie ◽  
Wen Shu ◽  
Hai-Shuang Wang ◽  
Li Chen ◽  
Jin Xu ◽  
...  
Keyword(s):  
Folic Acid ◽  
Cancer Treatment ◽  
Metal Organic Framework ◽  
Metal Organic ◽  
Organic Framework

Eu-MOF and its mixed-matrix membranes as fluorescent sensor for quantitative ratiometric pH and folic acid detection, and visible fingerprint identifying

2021 ◽  
Author(s):  
Yansong Jiang ◽  
Yating Huang ◽  
Xiangxiang Shi ◽  
Zijing Lu ◽  
Jiamo Ren ◽  
...  
Keyword(s):  
Folic Acid ◽  
Fluorescent Sensor ◽  
Metal Organic Framework ◽  
Three Dimensional ◽  
Mixed Matrix Membranes ◽  
Tetracarboxylic Acid ◽  
Mixed Matrix ◽  
Metal Organic ◽  
Solvothermal Conditions ◽  
Organic Framework

Here, we demonstrate the assembly of a new stable lanthanide-based metal-organic framework (MOF), Eu(HDPB)(phen) (1) (HDPB = (1,1ʹ:3ʹ,1ʹʹ-terphenyl)-3,3ʹʹ,5,5ʹʹ-tetracarboxylic acid, phen = 1,10-phenanthroline), with a three-dimensional framework under solvothermal conditions. 1...

scholarly journals Metal-Organic Framework Nanoparticle-Based Biomineralization: A New Strategy toward Cancer Treatment

Theranostics ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. 3134-3149 ◽  
Author(s):  
Chengchao Chu ◽  
Min Su ◽  
Jing Zhu ◽  
Dongsheng Li ◽  
Hongwei Cheng ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Metal Organic Framework ◽  
New Strategy ◽  
Metal Organic ◽  
Organic Framework

scholarly journals Metal organic framework-coated gold nanorod as an on-demand drug delivery platform for chemo-photothermal cancer therapy

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Junfeng Huang ◽  
Zhourui Xu ◽  
Yihang jiang ◽  
Wing-cheung Law ◽  
Biqin Dong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Near Infrared ◽  
Metal Organic Framework ◽  
Drug Loading ◽  
Zeolitic Imidazolate Framework ◽  
On Demand ◽  
Metal Organic ◽  
Organic Framework

AbstractChemo-photothermal therapy based on nanoparticles has emerged as a promising strategy for cancer treatment. However, its therapeutic efficacy and application potential are largely subjected to the uncontrollability and biotoxicity of functional nanoplatforms. Herein, a novel biocompatible and biodegradable metal organic framework (MOF), which was constructed by growing crystalline zeolitic imidazolate framework-8 on gold nanoroad (Au@ZIF-8), was designed and fabricated for efficient drug loading and controlled release. Owing to the large surface area and guest-matching pore size of ZIF-8, doxorubicin (DOX) was successfully loaded into the Au@ZIF-8 with a high drug loading efficiency of ~ 37%. Under NIR light or weakly acidic environment, the ZIF-8 layer was quickly degraded, which resulted in an on-demand drug release in tumour site. More importantly, under the irradiation of near infrared (NIR) laser, highly efficient cancer treatment was achieved in both in vitro cell experiment and in vivo tumour-bearing nude mice experiment due to the synergistic effect of photothermal (PTT) therapy and chemotherapy. In addition, the in vivo study revealed the good biocompatibility of Au@ZIF-8. This work robustly suggested that Au@ZIF-8 could be further explored as a drug delivery system for chemo-photothermal synergistic therapy.

Confined in-situ polymerization in nanoscale porphyrinic metal-organic framework for fluorescence imaging-guided synergistic phototherapy

2022 ◽  
Author(s):  
Wen Zhang ◽  
Bo Li ◽  
Wenyao Duan ◽  
Xin Yao ◽  
Xin Lu ◽  
...  
Keyword(s):  
Cancer Treatment ◽  
Fluorescence Imaging ◽  
Hybrid Material ◽  
In Situ Polymerization ◽  
Metal Organic Framework ◽  
Grand Challenge ◽  
Metal Organic ◽  
Organic Framework

Engineering a versatile nanoplatform integrating imaging and therapeutic functions for efficient cancer treatment remains grand challenge. Herein, a type of metal-organic framework (MOF)-based hybrid material for fluorescence imaging-guided synergistic phototherapy...

scholarly journals Biomimetic nanoscale metal–organic framework harnesses hypoxia for effective cancer radiotherapy and immunotherapy

2020 ◽  
Vol 11 (29) ◽  
pp. 7641-7653 ◽  
Author(s):  
Kaiyuan Ni ◽  
Guangxu Lan ◽  
Yang Song ◽  
Ziyang Hao ◽  
Wenbin Lin
Keyword(s):  
Cancer Treatment ◽  
Immune Checkpoint ◽  
Metal Organic Framework ◽  
Tumor Hypoxia ◽  
Immune Checkpoint Blockade ◽  
Checkpoint Blockade ◽  
Cancer Radiotherapy ◽  
Metal Organic ◽  
Synergistic Combination ◽  
Organic Framework

Biomimetic Hf-DBP-Fe harnesses tumor hypoxia for cancer treatment via RT-RDT and CDT as well as synergistic combination with immune checkpoint blockade.

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