Towards rational design of porous nanostructured biopolymeric microparticles for biomacromolecules separation: A case study of intraparticle diffusion facilitation and BSA adsorption on agarose microspheres

2018 ◽  
Vol 93 ◽  
pp. 518-528 ◽  
Author(s):  
Fatemeh Pourasgharian Roudsari ◽  
Mohammad Reza Mehrnia ◽  
Hooman Kaghazian
Keyword(s):  
Rational Design ◽  
Intraparticle Diffusion ◽  
Bsa Adsorption

Legalization in context: The design of the WTO’s dispute settlement system

2017 ◽  
Vol 19 (2) ◽  
pp. 304-319 ◽  
Author(s):  
Manfred Elsig
Keyword(s):  
Rational Design ◽  
Dispute Settlement ◽  
The United States ◽  
Settlement System ◽  
Trading System ◽  
Wto Dispute Settlement ◽  
Multilateral Trading System ◽  
The Creation ◽  
Dispute Settlement System

This article asks why the dispute settlement provisions of the multilateral trading system underwent significant reforms during the negotiations that led to the creation of the World Trade Organization (WTO) in 1995. Why did the leading trading powers accept a highly legalized system that departed from established political–diplomatic forms of settling disputes? The contribution of this article is threefold. First, it complements existing accounts that exclusively focus on the United States with a novel explanation that takes account of contextual factors. Second, it offers an in-depth empirical case study based on interviews with negotiators who were involved and novel archival evidence on the creation of the new WTO dispute settlement system. Third, by unpacking the long-standing puzzle of why states designed a highly legalized system, it addresses selected blind spots of the legalization and the rational design literatures with the aim of providing a better understanding about potential paths leading toward significant changes in legalization.

scholarly journals Rational Design of Dual Active Sites in a Single Protein Scaffold: A Case Study of Heme Protein in Myoglobin

ChemistryOpen ◽  
2016 ◽  
Vol 5 (3) ◽  
pp. 192-196 ◽  
Author(s):  
Xiao-Gang Shu ◽  
Ji-Hu Su ◽  
Ke-Jie Du ◽  
Yong You ◽  
Shu-Qin Gao ◽  
...  
Keyword(s):  
Active Sites ◽  
Rational Design ◽  
Heme Protein ◽  
Protein Scaffold ◽  
Single Protein

Utilization of Halogen Bond in Lead Optimization: A Case Study of Rational Design of Potent Phosphodiesterase Type 5 (PDE5) Inhibitors

2011 ◽  
Vol 54 (15) ◽  
pp. 5607-5611 ◽  
Author(s):  
Zhijian Xu ◽  
Zheng Liu ◽  
Tong Chen ◽  
TianTian Chen ◽  
Zhen Wang ◽  
...  
Keyword(s):  
Rational Design ◽  
Halogen Bond ◽  
Lead Optimization ◽  
Pde5 Inhibitors ◽  
Phosphodiesterase Type

Rational design of a novel aptamer-based biosensor for a target enzyme via modification of GFP-like fluorogens: Carboxylesterase 2A as a case study

2021 ◽  
Vol 330 ◽  
pp. 129312
Author(s):  
Yue Chen ◽  
Qing-Qing He ◽  
Dan-Dan Wang ◽  
Fang-Yuan Wang ◽  
Xiao-Qing Guan ◽  
...  
Keyword(s):  
Rational Design ◽  
Target Enzyme

scholarly journals Guidelines for rational design of high-performance absorbents: A case study of zeolite adsorbents for emerging pollutants in water

2017 ◽  
Vol 2 (4) ◽  
pp. 363-369 ◽  
Author(s):  
Xiaoxuan Wei ◽  
Ya Wang ◽  
Arturo J. Hernández-Maldonado ◽  
Zhongfang Chen
Keyword(s):  
High Performance ◽  
Rational Design ◽  
Emerging Pollutants

Appraisement Study on People Safety Evacuation in Large Scale Communal Building during Fire

2013 ◽  
Vol 864-867 ◽  
pp. 782-786
Author(s):  
Qi Wei Liu
Keyword(s):  
Markov Model ◽  
Rational Design ◽  
Large Scale ◽  
Traffic Density ◽  
Public Places ◽  
Safe Area ◽  
Fire Evacuation ◽  
Exit Door ◽  
Safety Evacuation

Fire danger degree of large public buildings is very high, difficulty to evacuation. Designed of fire evacuation is the most important factor when the safety degree of a large scale communal building is evaluated. Based on probabilistic analysis method - Markov model to predict public building fire evacuation rational design. Taking a large public places fire safety evacuation example case study, the results showed that: Markov model can scientifically and accurately, effectively predict extreme cases limited time traffic density, and each exit door emergency escape set a minimum flow of people. To ensure that the fire occurred within the time allowed people to evacuate to a safe area provides a theoretical basis.

Scope of design for production of wall partitions

2014 ◽  
Vol 12 (2) ◽  
pp. 263-279
Author(s):  
Alberto Casado Lordsleem Jr ◽  
Silvio Burrattino Melhado
Keyword(s):  
Construction Industry ◽  
Rational Design ◽  
Field Investigation ◽  
Building Construction ◽  
Content Type ◽  
Construction Companies ◽  
Accurate Definition ◽  
Personal Opinion ◽  
Definition Of

Purpose – The design for production of wall partitions (DPWP) offers high potential for improving the design process of building in Brazil. However, one of the problems worth mentioning is the lack of accurate definition of scope which leads to doubts about what, when and how it should be prepared, developed and delivered by the designers. The purpose of this paper is to assess the application of the Brazilian Association of Design Managers and Coordinators (AGESC) handbook scopes of DPWP in building construction. Design/methodology/approach – A case study involving a field investigation of eight construction organisations and DPWP designers in the cities of Recife and Sao Paulo in Brazil. Findings – The results obtained have shown that conformity (with specification) – the reference scope adopted AGESC handbook DPWP – was not entirely fulfilled by the companies, while the agreement (personal opinion on the appropriateness of the specification) with the scope was even lower among them. The major difference was found between conformity and agreement among the construction companies. Originality/value – Guidelines concerning how to use the AGESC handbook for DPWP, description of potential uses and amplifying of the contributions to greater integration between expectations and resulting products, call for rational design and execution of non-loadbearing masonry in the Brazilian construction industry.

scholarly journals Exploiting the Limits of Divergency Scaffolds in Natural Product Synthesis: The Case Study of Sesquiterpenoids

2021 ◽  
Author(s):  
Vera P. Demertzidou ◽  
Alexandros Zografos
Keyword(s):  
Natural Products ◽  
Total Synthesis ◽  
Natural Product ◽  
Rational Design ◽  
Natural Product Synthesis ◽  
Oxidation States

Divergent synthesis is a powerful but yet underdeveloped method to address the usual drawbacks of poor supply and confined diversity in the total synthesis of natural products. Herein, we describe the rational design behind the selection and the synthesis of a divergency scaffold for sesquiterpenoid lactones synthesis, as a case study, which provides access to a rich collection of carbocycles in different oxidation states within 8,12-sesquiterpenoids through simple, scalable transformations.

Sign in / Sign up

Export Citation Format

Share Document