Silk fibroin/nanohydroxyapatite hydrogels for promoted bioactivity and osteoblastic proliferation and differentiation of human bone marrow stromal cells

2018 ◽  
Vol 89 ◽  
pp. 336-345 ◽  
Author(s):  
Marta Ribeiro ◽  
Maria H. Fernandes ◽  
Marisa M. Beppu ◽  
Fernando J. Monteiro ◽  
Maria P. Ferraz
Keyword(s):  
Bone Marrow ◽  
Silk Fibroin ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Proliferation And Differentiation

scholarly journals Heparin Enriched-WPI Coating on Ti6Al4V Increases Hydrophilicity and Improves Proliferation and Differentiation of Human Bone Marrow Stromal Cells

2021 ◽  
Vol 23 (1) ◽  
pp. 139
Author(s):  
Davide Facchetti ◽  
Ute Hempel ◽  
Laurine Martocq ◽  
Alan M. Smith ◽  
Andrey Koptyug ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Protein Isolate ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Implant Surface ◽  
Bone Contact ◽  
Proliferation And Differentiation

Titanium alloy (Ti6Al4V) is one of the most prominent biomaterials for bone contact because of its ability to bear mechanical loading and resist corrosion. The success of Ti6Al4V implants depends on bone formation on the implant surface. Hence, implant coatings which promote adhesion, proliferation and differentiation of bone-forming cells are desirable. One coating strategy is by adsorption of biomacromolecules. In this study, Ti6Al4V substrates produced by additive manufacturing (AM) were coated with whey protein isolate (WPI) fibrils, obtained at pH 2, and heparin or tinzaparin (a low molecular weight heparin LMWH) in order to improve the proliferation and differentiation of bone-forming cells. WPI fibrils proved to be an excellent support for the growth of human bone marrow stromal cells (hBMSC). Indeed, WPI fibrils were resistant to sterilization and were stable during storage. This WPI-heparin-enriched coating, especially the LMWH, enhanced the differentiation of hBMSC by increasing tissue non-specific alkaline phosphatase (TNAP) activity. Finally, the coating increased the hydrophilicity of the material. The results confirmed that WPI fibrils are an excellent biomaterial which can be used for biomedical coatings, as they are easily modifiable and resistant to heat treatments. Indeed, the already known positive effect on osteogenic integration of WPI-only coated substrates has been further enhanced by a simple adsorption procedure.

scholarly journals The Effect of Simvastatin on the Proliferation and Differentiation of Human Bone Marrow Stromal Cells

2005 ◽  
Vol 20 (3) ◽  
pp. 438 ◽  
Author(s):  
Ki Hyun Baek ◽  
Won Young Lee ◽  
Ki Won Oh ◽  
Hyun Jung Tae ◽  
Jung Min Lee ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Proliferation And Differentiation

Therapeutic Impact of Human Bone Marrow Stromal Cells Expanded by Animal Serum–Free Medium for Cerebral Infarct in Rats

Neurosurgery ◽  
2011 ◽  
Vol 68 (6) ◽  
pp. 1733-1742 ◽  
Author(s):  
Taku Sugiyama ◽  
Satoshi Kuroda ◽  
Yukari Takeda ◽  
Mitsufumi Nishio ◽  
Masaki Ito ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Serum Free Medium ◽  
Free Medium ◽  
Serum Free ◽  
Therapeutic Impact

scholarly journals Leptin Induces Apoptosis via ERK/cPLA2/CytochromecPathway in Human Bone Marrow Stromal Cells

2003 ◽  
Vol 278 (24) ◽  
pp. 21920-21929 ◽  
Author(s):  
Ghi Su Kim ◽  
Jeong Soo Hong ◽  
Seung Wook Kim ◽  
Jung-Min Koh ◽  
Chung Sun An ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow

scholarly journals Directed Differentiation of Human Bone Marrow Stromal Cells to Fate-Committed Schwann Cells

2017 ◽  
Vol 9 (4) ◽  
pp. 1097-1108 ◽  
Author(s):  
Sa Cai ◽  
Yat-Ping Tsui ◽  
Kin-Wai Tam ◽  
Graham Ka-Hon Shea ◽  
Richard Shek-Kwan Chang ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Schwann Cells ◽  
Stromal Cells ◽  
Bone Marrow Stromal Cells ◽  
Marrow Stromal Cells ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Directed Differentiation
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